Research has proven that the most effective and widely used metal-containing chemotherapy anticancer drugs are cisplatin ([cis-PtCl(2)(NH(3))(2)]) and many platinum complexes, however, these compounds have significant disadvantages including poor water solubility and serious side effects. Thus researches in order to overcome these shortcomings have never interrupted. Many non-platinum complexes have been synthesized and tested, in which some palladium complexes show significant antitumor activity in normal tumor cells and lower resistance of tumor cells to clinical treatments as well as lower side effects. Mononuclear palladium complexes with aromatic N-containing ligands, amino acid ligands, S-donor ligands, and P-containing ligands have respective qualities and properties due to the different structures and properties of the ligands; some dinuclear palladium complexes possess interesting steric structures and good antitumor activity; a try to modify natural medicines with Pd(2+) leads the research to a new route. In this review, medicinal chemistry, the development status and interactions of palladium complexes with DNA are discussed in order to provide guidance and determine structure and antitumor activity relationships for continuing studies of these systems.
Aqueous Zn-ion batteries (AZIBs) have been recognized as promising energy storage devices due to their high theoretical energy density and cost-effectiveness. However, side reactions and Zn dendrite generation during cycling limit their practical application. Herein, ammonium acetate (CH 3 COONH 4 ) is selected as a trifunctional electrolyte additive to enhance the electrochemical performance of AZIBs. Research findings show that NH 4 + (oxygen ligand) and CH 3 COO -(hydrogenligand) with preferential adsorption on the Zn electrode surface can not only hinder Zn anode directly contact with active H 2 O, but also regulate the pH value of the electrolyte, thus suppressing the parasitic reactions. Additionally, the formed SEI is mainly consisted of Zn 5 (CO 3 ) 2 (OH) 6 with a high Zn 2+ transference number, which could achieve a dendrite-free Zn anode by homogenizing Zn deposition. Consequently, the Zn||Zn symmetric batteries with CH 3 COONH 4 -based electrolyte can operate steadily at an ultrahigh current density of 40 mA cm -2 with a cumulative capacity of 6880 mAh cm -2 , especially stable cycling at −10 °C. The assembled Zn||MnO 2 full cell and Zn||activated carbon capacitor also deliver prominent electrochemical reversibility. This work provides unique understanding of designing multi-functional electrolyte additive and promotes a long lifespan at ultrahigh current density for AZIBs.
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