Polyphenol rich fruit pulp of Aegle marmelos (L.) Correa exhibits nutraceutical properties to down regulate diabetic complications — An in vitro study

Prathapan, A.; Krishna, Mahesh S.; Nisha, V. M.; Sundaresan, A.; Raghu, K.

doi:10.1016/j.foodres.2012.06.008

Cited by 28 publications

(22 citation statements)

References 30 publications

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“…The results were comparable with the reported results of TPC of the fruit pulp of A. marmelos. 3 Antioxidant activity of AME was evaluated by different detection methods. Primary antioxidants have been shown to react against the oxidative stress by breaking chain reaction or by scavenging free radicals.…”

Section: Resultsmentioning

confidence: 99%

“…Aqueous extract of bael fruit has shown hypoglycemic effects in streptozotocin induced diabetes in rats when administered orally and intra peritoneally. 3 Leaf extracts of A. marmelos are reported to have cardiotonic, hypoglycemic, antidyslipidemic, anticancer effects and also used to cure opthalmia, ulcers, dropsy, cholera and beri beri. The leaf extract was also reported to regenerate pancreatic islets in diabetic rats; although the mechanisms for these activities are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

Kumar¹,

Bodla²,

Bansal³

2016

Phcogj

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Introduction: Leaf extracts of Aegle marmelos are reported to have hypoglycemic and anticancer effects. While a lot of information is available about the antioxidant activity of fruit of A. marmelos not much information is available about the antioxidant activity of the leaf of A. marmelos. Objective: The primary objective if this study was to ascertain the antioxidant activity of leaf extract of A. marmelos (AME). Methods: AME was evaluated for total phenolic content (TPC) and total flavonoid content (TFC) by Folin-Ciocalteau reagent method and by aluminium chloride method, respectively. Antioxidant activity of AME was assessed by FRAP assay, DPPH assay, ABTS cation scavenging activity and by reducing power determination. Results: High levels of TPC and TFC were found in AME which showed antioxidant activity comparable to vitamin C. Significant correlation

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

Kumar¹,

Bodla²,

Bansal³

2016

Phcogj

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“…Natural flavanoids like luteolin (12), apigenin (14), myrcetin (35) and silymarin (38) also exhibited these properties. Another 30 approach to reduce the AGE levels is by using cross link breakers such as N-phenacyl thiazolinium bromide (PTB) and N-phenacyl-4,5-dimethylthiazolium chloride (ALT-711/alagebrium), which break the AGE cross-links.…”

Section: Advanced Glycation End Product (Age) Inhibitorsmentioning

confidence: 95%

Recent development of plant products with anti-glycation activity: a review

et al. 2015

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“…The therapeutic challenge of diabetes lies in the need for intensive glycaemic control and maintenance of glycaemia within a strict normal narrow range (Du et al, 2012). One of the therapeutic approaches to controlling postprandial blood glucose (PBG) is to retard the absorption of glucose via inhibition of glycosidase, such as α-glucosidase and α-amylase (Prathapan et al, 2012). Previous researches have demonstrated that glycosidase inhibitors exhibit anti-diabetic effects (Bu et al, 2010;Liu et al, 2012;Nwosu et al, 2011;Wei et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

Wan

Yang

Cai

et al. 2015

J. Ocean Univ. China

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In the present study, ultrasonic extraction technique (UET) is used to improve the yield of polysaccharides from Laminaria japonica (LJPs). And their antioxidative as well as glycosidase inhibitory activities are investigated. Box-Behnken design (BBD) combined with response surface methodology (RSM) is applied to optimize ultrasonic extraction for polysaccharides. The optimized conditions are obtained as extraction time at 54 min, ultrasonic power at 1050 W, extraction temperature at 80℃ and ratio of material to solvent at 1:50 (g mL −1 ). Under these optimal ultrasonic extraction conditions, an actual experimental yield (5.75% ± 0.3%) is close to the predicted result (5.67%) with no significant difference (P > 0.05). Vitro antioxidative and glycosidase inhibitory activities tests indicate that the crude polysaccharides (LJP) and two major ethanol precipitated fractions (LJP1 and LJP2) are in a concentration-dependent manner. LJP2 (30%60% ethanol precipitated polysaccharides) possesses the strongest α-glucosidase inhibitory activity and moderate scavenging activity against hydroxyl radicals (66.09% ± 2.19%, 3.0 mg mL −1 ). Also, the inhibitory activity against α-glucosidase (59.08% ± 3.79%, 5.0 mg mL −1 ) is close to that of acarbose (63.99% ± 3.27%, 5.0 mg mL −1 ). LJP1 (30% ethanol precipitated polysaccharides) exhibits the strongest scavenging activity against hydroxyl radicals (99.80% ± 0.00%, 3.0 mg mL −1 ) and moderate α-glucosidase inhibitory activity (47.76% ± 1.92%, 5.0 mg mL −1 ). LJP shows the most remarkable DPPH scavenging activity (66.20% ± 0.11%, 5.0 mg mL −1 ) but weakest α-glucosidase inhibitory activity (37.77% ± 1.30%, 5.0 mg mL −1 ). However, all these LJPs exert weak inhibitory effects against α-amylase. These results show that UET is an effective method for extracting bioactive polysaccharides from seaweed materials. LJP1 and LJP2 can be developed as a potential ingredient in hypoglycemic agents or functional food for the management of diabetes. This study provides scientific evidence and advances in the preparation technology and a hypoglycemic activities evaluation method for seaweed polysaccharides, especially glycosidase inhibition in combination with an antioxidative activity evaluation method.

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Polyphenol rich fruit pulp of Aegle marmelos (L.) Correa exhibits nutraceutical properties to down regulate diabetic complications — An in vitro study

Cited by 28 publications

References 30 publications

Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

Antioxidant Activity of Leaf Extract of Aegle marmelos Correa ex Roxb.

Recent development of plant products with anti-glycation activity: a review

Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities

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