Polyostotic heterogeneity of the spine in osteoporosis. Quantitative analysis and three-dimensional morphology

Amling, Michael; Grote, H.; Pösl, M.; Hahn, Michael; Delling, G.

doi:10.1016/s0169-6009(08)80193-6

Cited by 46 publications

(22 citation statements)

References 23 publications

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“…Most previous studies of age-related changes in vertebral and iliac crest bone microstructure have been performed using 2D histomorphometric methods [9][10][11][12][13]. However, some of these 2D measures such as trabecular thickness are based on model assumptions leading to biased determinations of the bone microstructure [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities

et al. 2014

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Section: Introductionmentioning

confidence: 99%

Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities

et al. 2014

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“…Observational and histological studies have shown that the cancellous structure of vertebral bodies is comprised mainly of vertical plates with interconnecting horizontal rods [6]. It has also been shown histologically that there is considerable heterogeneity in the spatial distribution of cancellous bone within vertebral bodies [7,8].…”

Section: Introductionmentioning

confidence: 99%

Vertebral body bone strength: the contribution of individual trabecular element morphology

et al. 2011

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Microarchitectural measures of individual trabeculae that contribute to bone strength have been identified. In addition to the contribution of BV/TV, trabecular rod morphology increased the determination of AP strength by 57%, whereas measures of trabecular plate and rod morphology increased determination of SI strength by 13%. Decomposing vertebral body bone architecture into its constituent morphological elements shows that trabecular element morphology has specific functional roles to assist in maintaining skeletal integrity.

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“…The diabetic sand rat (Psammomus obesus) has been shown to develop a greater degree of OP in weight-bearing bones than in the spine (Amir et al, 1991) and there is growing evidence that bone volume in human osteoporotic subjects varies in axial and appendicular bones (Amling et al, 1994;Riggs et al, 1981). To address this question, we compared the degree of OP in the axial and appendicular skeleton to determine which bones are more suitable for the study of OP in the Cohen diabetic rat.…”

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confidence: 99%

Osteoporosis in the Cohen Diabetic Rat: Correlation Between Histomorphometric Changes in Bone and Microangiopathy

Amir

Rosenmann

Sherman

et al. 2002

Laboratory Investigation

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SUMMARY:Osteoporosis is well documented in type I diabetes, but its occurrence is controversial in type II diabetes.Microangiopathy is a major complication of type I and type II diabetes. We studied bone and microvascular changes in the Cohen diabetic rat, a unique nonobese model of noninsulin-dependent diabetes mellitus. The aim of this study was to find whether there is a temporal correlation between the onset of these two complications. The diabetic rats were divided into three groups (A, B, and C) according to duration of diabetes (2 months, 3 months, and 7 to 8 months, respectively). Trabecular bone area was assessed by computerized image analysis and microangiopathy by means of renal function tests, histologic examination of the kidneys, and ultrastructural measurement of the width of capillary basement membranes. Bone density of the distal femur and vertebra was significantly reduced in the diabetic rats relative to the control rats in all three groups (Group A femur: 11.5 Ϯ 1.6% versus 21.8 Ϯ 3.0%, p Ͻ 0.02; Group A vertebra: 15.9 Ϯ 1.6% versus 28.5 Ϯ 2.0%, p Ͻ 0.02; Group C femur: 7.9 Ϯ 1.1% versus 29.6 Ϯ 3.5%, p Ͻ 0.001; Group C vertebra: 11.4 Ϯ 0.7% versus 37.1 Ϯ 1.9%, p Ͻ 0.002). Renal function tests were normal in the Group A diabetic rats and there was marked albuminuria in the Group C diabetic rats. Histologic changes in the kidneys were seen only in the Group C diabetic rats. Five of 15 Group C diabetic rats showed no albuminuria or histologic evidence of kidney damage. The bone density in this subgroup was reduced relative to controls to the same degree as that of the rats with renal damage. There was no evidence of capillary basement membrane thickening in the Group A diabetic rats. Our findings indicate that in the Cohen diabetic rat, osteoporosis precedes the onset of microangiopathy. Microangiopathy probably does not play an important role in the pathogenesis of osteoporosis in this animal model. (Lab Invest 2002, 82:1399 -1405.

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Polyostotic heterogeneity of the spine in osteoporosis. Quantitative analysis and three-dimensional morphology

Cited by 46 publications

References 23 publications

Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities

Age-related changes in vertebral and iliac crest 3D bone microstructure—differences and similarities

Vertebral body bone strength: the contribution of individual trabecular element morphology

Osteoporosis in the Cohen Diabetic Rat: Correlation Between Histomorphometric Changes in Bone and Microangiopathy

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