Vertebral body bone strength: the contribution of individual trabecular element morphology

Parkinson, Ian H.; Badiei, Arash; Stauber, Martin; Codrington, John; Müller, Ralph; Fazzalari, Nicola L.

doi:10.1007/s00198-011-1832-6

Cited by 25 publications

(11 citation statements)

References 36 publications

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“…In line with previous studies [34], [35], HU resulted in marked deterioration in trabecular bone microarchitecture, as evidenced by decreased trabecular BMD, Tb.N, Tb.Th and BV/TV, and increased Tb.Sp. More importantly, increased trabecular SMI was also observed in HU rats, revealing a potentially dramatic reduction of trabeculae with plate-like structures [36]. Moreover, in accordance with previous findings [35], skeletal disuse by HU caused lower cortical bone thickness in the present study.…”

Section: Discussionsupporting

confidence: 93%

Moderate-Intensity Rotating Magnetic Fields Do Not Affect Bone Quality and Bone Remodeling in Hindlimb Suspended Rats

Jing

Cai

et al. 2014

PLoS ONE

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Abundant evidence has substantiated the positive effects of pulsed electromagnetic fields (PEMF) and static magnetic fields (SMF) on inhibiting osteopenia and promoting fracture healing. However, the osteogenic potential of rotating magnetic fields (RMF), another common electromagnetic application modality, remains poorly characterized thus far, although numerous commercial RMF treatment devices have been available on the market. Herein the impacts of RMF on osteoporotic bone microarchitecture, bone strength and bone metabolism were systematically investigated in hindlimb-unloaded (HU) rats. Thirty two 3-month-old male Sprague-Dawley rats were randomly assigned to the Control (n = 10), HU (n = 10) and HU with RMF exposure (HU+RMF, n = 12) groups. Rats in the HU+RMF group were subjected to daily 2-hour exposure to moderate-intensity RMF (ranging from 0.60 T to 0.38 T) at 7 Hz for 4 weeks. HU caused significant decreases in body mass and soleus muscle mass of rats, which were not obviously altered by RMF. Three-point bending test showed that the mechanical properties of femurs in HU rats, including maximum load, stiffness, energy absorption and elastic modulus were not markedly affected by RMF. µCT analysis demonstrated that 4-week RMF did not significantly prevent HU-induced deterioration of femoral trabecular and cortical bone microarchitecture. Serum biochemical analysis showed that RMF did not significantly change HU-induced decrease in serum bone formation markers and increase in bone resorption markers. Bone histomorphometric analysis further confirmed that RMF showed no impacts on bone remodeling in HU rats, as evidenced by unchanged mineral apposition rate, bone formation rate, osteoblast numbers and osteoclast numbers in cancellous bone. Together, our findings reveal that RMF do not significantly affect bone microstructure, bone mechanical strength and bone remodeling in HU-induced disuse osteoporotic rats. Our study indicates potentially obvious waveform-dependent effects of electromagnetic fields-stimulated osteogenesis, suggesting that RMF, at least in the present form, might not be an optimal modality for inhibiting disuse osteopenia/osteoporosis.

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Section: Discussionsupporting

confidence: 93%

Moderate-Intensity Rotating Magnetic Fields Do Not Affect Bone Quality and Bone Remodeling in Hindlimb Suspended Rats

Jing

Cai

et al. 2014

PLoS ONE

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“…Although there were no significant differences between cubic and cylindrical µFE models, the positions of the trabecular bone core should be identical. In experimental compression tests, trabecular bone cores extracted from vertebral bodies are often used (23,32). In our study, cubic and cylindrical µFE models were constructed to investigate if there were differences between the two models.…”

Section: Discussionmentioning

confidence: 99%

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Wen

Yan

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Assessing the biomechanical properties of trabecular bone is of major biological and clinical significance for the research of bone diseases, fractures and their treatments. Micro-finite element (µFE) models are becoming increasingly popular for investigating the biomechanical properties of trabecular bone. The shapes of µFE models typically include cube and cylinder. Whether there are differences between cubic and cylindrical µFE models has not yet been studied. In the present study, cubic and cylindrical µFE models of human vertebral trabecular bone were constructed. A 1% strain was prescribed to the model along the superior-inferior direction. E values were calculated from these models, and paired t-tests were performed to determine whether these were any differences between E values obtained from cubic and cylindrical models. The results demonstrated that there were no statistically significant differences in the E values between cubic and cylindrical models, and there were no significant differences in Von Mises stress distributions between the two models. These findings indicated that, to construct µFE models of vertebral trabecular bone, cubic or cylindrical models were both feasible. Choosing between the cubic or cylindrical µFE model is dependent upon the specific study design.

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“…Previous studies suggested that the trabecular architecture of vertebral centrum could affect the mechanical properties of vertebral bone [22, 40]. The trabecular thickness (Tb.Th) and fracture strength of rat vertebrae were shown to have significantly decreased 2 months post-OVX, while trabecular formation and resorption surface area were increased [22].…”

Section: Discussionmentioning

confidence: 99%

Increased variability of bone tissue mineral density resulting from estrogen deficiency influences creep behavior in a rat vertebral body

Navalgund

Tee

et al. 2012

Bone

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Progressive vertebral deformation increases the fracture risk of a vertebral body in the postmenopausal patient. Many studies have observed that bone can demonstrate creep behavior, defined as continued time-dependent deformation even when mechanical loading is held constant. Creep is a characteristic of viscoelastic behavior, which is common in biological materials. We hypothesized that estrogen deficiency-dependent alteration of the mineral distribution of bone at the tissue level could influence the progressive postmenopausal vertebral deformity that is observed as the creep response at the organ level. The objective of this study was thus to examine whether the creep behavior of vertebral bone is changed by estrogen deficiency, and to determine which bone property parameters are responsible for the creep response of vertebral bone at physiological loading levels using an ovariectomized (OVX) rat model. Correlations of creep parameters with bone mineral density (BMD), tissue mineral density (TMD) and architectural parameters of both OVX and sham surgery vertebral bone were tested. As the vertebral creep was not fully recovered during the post-creep unloading period, there was substantial residual displacement for both the sham and OVX groups. A strong positive correlation between loading creep and residual displacement was found (r=0.868, p<0.001). Of the various parameters studied, TMD variability was the parameter that best predicted the creep behavior of the OVX group (p<0.038). The current results indicated that creep caused progressive, permanent reduction in vertebral height for both the sham and OVX groups. In addition, estrogen deficiency-induced active bone remodeling increased variability of trabecular TMD in the OVX group. Taken together, these results suggest that increased variability of trabecular TMD resulting from high bone turnover influence creep behavior of the OVX vertebrae.

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Vertebral body bone strength: the contribution of individual trabecular element morphology

Cited by 25 publications

References 36 publications

Moderate-Intensity Rotating Magnetic Fields Do Not Affect Bone Quality and Bone Remodeling in Hindlimb Suspended Rats

Moderate-Intensity Rotating Magnetic Fields Do Not Affect Bone Quality and Bone Remodeling in Hindlimb Suspended Rats

Influence of the shape of the micro-finite element model on the mechanical properties calculated from micro-finite element analysis

Increased variability of bone tissue mineral density resulting from estrogen deficiency influences creep behavior in a rat vertebral body

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