Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers

Darling, Mark; Schneider, Johann; Phillips, V M

doi:10.1016/s1368-8375(02)00003-9

Cited by 98 publications

(78 citation statements)

References 31 publications

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“…This result are cosistent with a literature review (20) that stated that vimentin is more frequently present in PLGAs than in ACCs. These authors concluded that vimentin is the only marker able to distinguish between these two neoplasms.…”

Section: Discussionsupporting

confidence: 88%

Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

et al. 2007

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Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.

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Section: Discussionsupporting

confidence: 88%

Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

et al. 2007

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“…Additionally, Woo et al [17] reported that CD43 is more strongly expressed in adenoid cystic carcinoma than PLGA, a finding that has not yet been confirmed by other investigators. Unfortunately, other immunostains, including S100 and bcl-2, have not consistently helped differentiate PLGA from either adenoid cystic carcinoma or pleomorphic adenoma [13,18,39]. p63, an immunohistochemical stain that highlights basal and myoepithelial differentiation, has never routinely been used to distinguish between PLGA, adenoid cystic carcinoma, and pleomorphic adenoma because all three lesions are frequently positive for this marker [23,25,26].…”

Section: Discussionmentioning

confidence: 99%

“…However, while many immunohistochemical stains (e.g., c-kit, Ki-67, glial fibrillary acidic protein, CD43, S100, bcl-2, etc.) have been used to aid in this differential diagnosis, none of them distinguishes these tumors in a consistently reliable manner [9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma

Rooper

Sharma

Bishop

2014

Head and Neck Pathol

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Polymorphous low grade adenocarcinoma (PLGA) is a tumor of minor salivary glands that exhibits considerable morphologic overlap with adenoid cystic carcinoma and cellular pleomorphic adenoma, especially in small biopsy specimens. Unlike these other tumor types. PLGAs do not harbor a myoepithelial component, yet their frequent positivity for p63 diminishes the usefulness of this particular myoepithelial marker as a discriminating immunostain. p40 is an antibody that recognizes DNp63, a p63 isoform that is more specific for true myoepithelial differentiation. As such, p40 immunostaining could help distinguish PLGAs from adenoid cystic carcinomas and pleomorphic adenomas. In this study, p63 and p40 immunohistochemistry was performed on paraffin embedded, formalin fixed tissue from 11 PLGAs, 101 adenoid cystic carcinomas, and 31 pleomorphic adenomas. All 11 PLGAs (100 %) were positive for p63 but completely negative for p40. Among adenoid cystic carcinomas, 91 of 101 (90 %) were positive for p63 and 90/101 (89 %) were positive for p40. The single discordant p63?/p40-adenoid cystic carcinoma exhibited solid architecture and high grade features not typically seen in PLGA. Among pleomorphic adenomas, 21/31 (68 %) were positive for p63 and 13/31 (42 %) were positive for p40. For the pleomorphic adenomas, the discordant p63?/p40-staining pattern was seen only in the overtly mesenchymal chondromyxoid stroma. The cellular epithelial component of the pleomorphic adenomas demonstrated concordant p63?/p40? or p63-/p40-immunophenotypes. PLGA consistently exhibits a p63?/p40-immunophenotype that can help distinguish it from adenoid cystic carcinoma and cellular pleomorphic adenoma, tumors that characteristically demonstrate concordant p63 and p40 immunostaining patterns. A p63/p40 immunohistochemical panel can provide a valuable tool for making the distinction between these morphologically similar but clinically divergent entities.

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“…Elle représente 7 à 11 % de toutes les tumeurs malignes et bénignes et 19 à 26 % des tumeurs malignes des glandes salivaires accessoires [6].…”

Section: Discussionunclassified

“…L'APBG se révèle positif pour les marqueurs immunohistologiques S-100, cytokeratine CAM 5.2 et la vimentine [6,12,15]. Quant à notre prélèvement, le diagnostic se posait sans avoir recours à l'immunohistochimie.…”

Section: Discussionunclassified

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

Naji

Alaoui

Yahya

2016

Med Buccale Chir Buccale

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Résumé -Introduction : L'adénocarcinome polymorphe de bas grade (APBG) est une tumeur maligne rare qui se trouve presque exclusivement située dans les glandes salivaires accessoires. Il survient fréquemment chez les patients entre 30 et 70 ans, avec un ratio femme-homme de 2/1. Il est généralement situé dans le palais dur ou mou. Observation : Il s'agissait d'une patiente de 38 ans, consultant suite à l'apparition d'une tuméfaction bleutée au niveau du palais mou droit, évoluant depuis un an, indolore et recouverte d'une muqueuse d'aspect normal. Le diagnostic évoqué était un adénome pléomorphe mais l'examen histologique après exérèse chirurgicale révélait un APBG. Une reprise des marges d'exérèse était nécessaire associée à une plastie. Discussion : Le diagnostic de l'APBG est basé principalement sur les éléments cliniques et radiologiques. L'anatomopathologie permet la confirmation et la classification de la lésion. Le traitement reste essentiellement chirurgical. Le pronostic est bon malgré un taux de récidive de l'ordre de 17 % à 24 %. Bien que rares, les métastases dans les ganglions lymphatiques régionaux peuvent se produire dans 9 % des cas. Conclusion : L'APBG est une tumeur non agressive dont le pronostic dépend de plusieurs facteurs dont le délai de consultation, d'où l'importance d'un dépistage précoce.Abstract -Polymorphous low-grade adenocarcinoma of the soft palate: review and case report. Introduction: Polymorphous low-grade adenocarcinoma (PLGA) is a rare malignant tumor that is found almost exclusively in the minor salivary glands. It frequently occurs in patients between 30 and 70 years old, with a female to male ratio of 2/1. It is usually located in the hard or soft palate. Observation: A 38-year-old female patient presented with a bluish swelling in the right side of the soft palate which had evolved for a year, which was painless and covered with a mucosa of normal appearance. The first diagnosis suggested was pleomorphic adenoma, but the histologic exam following the surgical biopsy revealed a PLGA. Surgical revision of the safety margins was necessary together with mucosal plasty. Discussion: The diagnosis of PLGA is based mainly on clinical and radiological aspects, but a histologic exam is absolutely necessary to confirm it, and for classification of the lesion. Treatment is mainly surgical. The prognosis is good, although the recurrence rate is 17% to 24%. Although seldom, metastases in regional lymph nodes may occur in 9% of cases. Conclusion: PLGA is a non-aggressive tumor whose prognosis depends on several factors including the consultation period. This highlights the importance of early detection.

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Polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma: a review and comparison of immunohistochemical markers

Cited by 98 publications

References 31 publications

Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors

Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma

Adénocarcinome polymorphe de bas grade du palais mou : revue et rapport de cas

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