Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation

Abstract

Activation of the renin-angiotensin system (RAS) is associated with atrial fibrillation (AF). The aim of this study was to investigate the relation between AF and polymorphisms in RAS. One hundred and fifty patients with AF, 100 patients with no documented episode of AF and 100 healthy subjects were consecutively recruited into the study. The angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, and the M235T, A-20C, and G-6A polymorphisms of the angiotensinogen gene were genotyped. Patients with AF had significantly lower frequency of II genotype of ACE I/D and higher frequency of angiotensinogen M235T polymorphism T allele and TT genotype and G-6A polymorphism G allele and GG genotype compared with the controls. AF patients had significantly larger left atrium, higher left ventricular mass index (LVMI) and higher frequency of significant valvular pathology. ACE I/D polymorphism II genotype, angiotensinogen M235T polymorphism TT genotype and G allele and GG genotype of angiotensinogen G-6A polymorphism were still independently associated with AF when adjusted for left atrium, LVMI and presence of significant valvular pathology. Genetic predisposition might be underlying the prevalence of acquired AF. Patients with a specific genetic variation in the RAS genes may be more liable to develop AF.

Polymorphisms of Renin-Angiotensin-Aldosterone System Gene in Chinese Han Patients with Nonfamilial Atrial Fibrillation

“…In previous studies, rs699 proved to be associated with atrial fibrillation in Chinese Taiwan and Turkish population[2, 11], but it did not exhibit association in our sample set. However, it showed association as haplotype form.…”

Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies

“…10 Further research on the association between ACE I/D polymorphisms and AF was conducted from 2010 to 2013. [11][12][13][14][15] Therefore, we conducted a meta-analysis of all 23 …”

Molecular genetic markers of atrial fibrillation

“…Ренин-ангиотензиновая система играет важную роль в патогенезе ФП [41], в частности, имеются исследования о роли генов ACE, AGT и AGTR1 в формировании предрасположенности к развитию данной патологии. Молекулярно-генетические маркеры фибрилляции предсердий ации замен M235T, G-6A и G-217A в гене AGT с риском развития ФП [42]; позднее данный факт был подтвержден -аллель T и генотип T/T полиморфизма M235T, а также аллель G и генотип G/G полиморфизма G-6A продемонстрировали ассоциации с повышенным риском развития данной патологии [43,44]. В продолжение, в 2008 г., ýта же группа провела повторное исследование с привлечением большего количества пациентов (1 236 человек).…”