Angiotensin-converting enzyme insertion/deletion gene polymorphisms associated with risk of atrial fibrillation: A meta-analysis of 23 case-control studies

Abstract

Aims: The renin-angiotensin-aldosterone system is important to the development of atrial fibrillation (AF). A lot of research has focused on the relationship between angiotensin-converting enzyme (ACE) insertion (I) /deletion (D) gene polymorphisms and AF, with inconsistent results. A meta-analysis was carried out to find the correlation between ACE I/D gene polymorphisms and AF. Methods: Data were extracted from articles published before September 2013 on ACE I/D polymorphisms and AF in Embase, PubMed, WanFangData, and China National Knowledge Infrastructure. Results: The recessive model found that ACE I/D gene polymorphisms were related to AF (odds ratio (OR) = 1.61, 95% confidence interval (CI) = 1.16–1.72). Subgroup analysis showed a significant association in the recessive model for Asian (OR = 1.40, 95% CI = 1.19–1.80) and Caucasian (OR = 1.42, 95% CI = 1.01–1.99) populations. Conclusions: ACE I/D gene polymorphisms and AF are significantly related to ethnicity. Individuals with the ACE D/D genotype appear to be at higher risk of AF.

<b><i>ACE</i></b> Insertion/Deletion Polymorphism Associated with Caries in Permanent but Not Primary Dentition in Czech Children

“…It is involved in the regulation of blood pressure and [Rigat et al, 1990]. Although this variant was primarily investigated in relation to cardiovascular diseases [Yang et al, 2013;Song et al, 2014;Zhao et al, 2014;Ma et al, 2015], cancer [Zhang et al, 2014] and diabetic nephropathy [Yu et al, 2012;Rahimi et al, 2014], some studies have also associated this gene polymorphism with various diseases in the oral cavity. In the Czech population, the D allele was previously found to be marginally risky for chronic periodontitis [Izakovicova Holla et al, 2001] and in the Korean population, the DD genotype has already been associated with chronic periodontitis [Kang et al, 2015].…”

The Role of the I/D Polymorphism of the ACE Gene in the Development of Atrial Fibrillation

“…в своей работе выявили преобладание D аллеля полиморфизма I / D гена ACE у пациентов с первичной ФП, что еще раз доказывает роль ренин-ангиотензин-альдостероновой системы в патофизиологии ФП [10]. В ходе нескольких мета-анализов различными исследователями получена взаимосвязь полиморфизма I / D гена АСЕ с риском развития ФП [11,12]. Изучалась также взаимосвязь данного полиморфизма с риском рецидива ФП после катетерной абляции [13,14].…”

Molecular genetic markers of atrial fibrillation

“…После публикации данного метаанализа был проведен целый ряд исследований I/D-полиморфизма гена ACE. Результаты большинства работ подтверждают более ранние данные об ассоциации генотипов I/D и D/D гена ACE с повышенным риском развития ФП [43,48,49]. Однако одно из последних исследований, выполненное на российской популяции, напротив, говорит о том, что носительство гомозиготного генотипа D/D может обладать условно протективным ýффектом в отношении развития ФП [50].…”