Polymorphisms of pro‐inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a <scp>C</scp>olombian population

Amaya, Mildred; Criado, Libeth; Fuentes, Bibiana Yorley Blanco; Gómez, Montse; Torres, Osvaldo García; Flórez, Luisa Teresa; González, Clara Isabel; Flórez, Óscar

doi:10.1111/j.1365-2591.2012.02097.x

Cited by 35 publications

(50 citation statements)

References 43 publications

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“…The hypothesis that individual genetic susceptibility through gene polymorphisms can contribute to periapical disease risk has been explored recently in the literature (10)(11)(12)(13)(14). However, gene polymorphisms may explain only a fraction of the associated risk because other genetic or ''epigenetic'' events may confer additional susceptibility to disease.…”

Section: Discussionmentioning

confidence: 98%

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FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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Section: Discussionmentioning

confidence: 98%

“…Recent evidence suggests that genetic predisposition of the host can contribute to an individual's susceptibility to persistent apical periodontitis (10)(11)(12)(13)(14). Polymorphisms in disease-relevant genes, such as cytokines and matrix metalloproteinases, have been shown to be associated with pulpal and periapical pathologies (10)(11)(12).…”

mentioning

confidence: 98%

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Campos

Franscisconi

Okehie

et al. 2015

Journal of Endodontics

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“…Amaya et al (26) did not find statistical association between AP and the studied polymorphism in TNF-α. However, they evaluated the association by combining polymorphisms: IL1β +3954 C, IL12 β +1188 A, TNF-α -308 G>A and IL-8/CXCL8 -251 A.…”

Section: Discussionmentioning

confidence: 99%

“…CD14, TLR4, MMP2, MMP3, MMP9, MMP13, MMP14, TIMP2, IL-1, FcƔRIIIa, IL1-β;). Finally, two studies met the inclusion criteria, De Sá et al (25) and Amaya et al (26), and were included in the qualitative assessment (Table 2). Regarding this aspect, Amaya et al (26) failed in the control group criteria due to a smaller control group than case group.…”

Section: Meta-analysismentioning

confidence: 99%

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

et al. 2017

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Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and metaanalysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.

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“…Previous studies indicate the association between IL-8 SNPs and periodontitis compared with healthy controls. Some studies suggest that SNPs within IL-8 are associated with susceptibility to periodontitis [24]–[28], whereas other studies failed to demonstrate associations between periodontitis and IL-8 polymorphisms [29], [30]. The association between IL-8 and chronic periodontitis has not been systematically investigated in the Han Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Interleukin-8 Gene Variants Reveals Their Relative Importance as Genetic Susceptibility Factors for Chronic Periodontitis in the Han Population

Zhang

et al. 2014

PLoS ONE

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Interleukin (IL)-8, an important chemokine that regulates the inflammatory response, plays an important role in periodontitis. Previous studies indicate that certain IL-8 gene polymorphisms are associated with periodontitis susceptibility in some populations. However, the literature is somewhat contradictory, and not all IL-8 polymorphisms have been examined, particularly in Han Chinese individuals. The aim of this study was to investigate the association of every IL-8 SNP with chronic periodontitis in Han Chinese individuals. We analyzed 23 SNPs with minor allele frequency (MAF)≥0.01, which were selected from 219 SNPs in the NCBI dbSNP and preliminary HapMap data analyses from a cohort of 400 cases and 750 controls from genetically independent Han Chinese individuals. Single SNP, haplotype and gender-specific associations were performed. We found that rs4073 and rs2227307 were significantly associated with chronic periodontitis. Further haplotype analysis indicated that a haplotype block (rs4073-rs2227307-rs2227306) that spans the promoter and exon1 of IL-8 was highly associated with chronic periodontitis. Additionally, the ATC haplotype in this block was increased 1.5-fold in these cases. However, when analyzing the samples by gender, no significant gender-specific associations in IL-8 were observed, similar to the results of haplotype association analyses in female and male subgroups. Our results provide further evidence that IL-8 is associated with chronic periodontitis in Han Chinese individuals. Furthermore, our results confirm previous reports suggesting the intriguing possibilities that IL-8 plays a role in the pathogenesis of chronic periodontitis and that this gene may be involved in the etiology of this condition.

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Polymorphisms of pro‐inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population

Cited by 35 publications

References 43 publications

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

FOXP3 DNA Methylation Levels as a Potential Biomarker in the Development of Periapical Lesions

Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

Analysis of Interleukin-8 Gene Variants Reveals Their Relative Importance as Genetic Susceptibility Factors for Chronic Periodontitis in the Han Population

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