Polymorphisms of interleukin‐1 and interleukin‐2 genes in patients with gastric cancer in Korea

Abstract

Background and Aim: Interleukin (IL)-1 gene polymorphism has been reported to be associated with the increment of gastric cancer (GC) and the decrement of duodenal ulcers (DU). In addition, IL-2 is known to induce Helicobacter pylori (H. pylori)-associated gastric atrophy, but it is not known whether IL-2 gene polymorphism increases the risk of GC (GC) or peptic ulcer diseases. Therefore, we compared the genotypes of IL-1B, IL-1RN, and IL-2 gene polymorphisms with risk of gastric ulcers (GU), GC, and DU in Korean patients. Methods: In total, 116 GU, 122 GC, and 104 DU patients were included consecutively and compared with 100 healthy controls. Polymorphisms of the IL-1B-511/-31 gene, the pentaallelic variable number of tandem repeats of the IL-1RN gene, and the IL-2-330 gene were analyzed by polymerase chain reaction with restriction fragment length polymorphism or confronting two-pair primers methods. There was also no significant difference in the genotypes of these cytokine polymorphisms between the study group (GU or DU) and control group. In addition, genotypic frequency was not associated with H. pylori positivity and histological type of GC. Conclusion: IL-1B-511, IL-1RN, and IL-2 genetic polymorphisms were not important contributors to the pathogenesis of GU, GC, and DU in Korean patients.

Human Interleukin 2 (IL-2) Promotion of Immune Regulation and ClinicalOutcomes: A Review

“…Polymorphism -330 T/G (rs2069762) is located in the gene promoter region and is associated with increased susceptibility to inflammatory diseases and cancer, including rheumatoid arthritis and myeloid leukemia [28][29][30]. Additionally, studies show that changes in the serum IL-2 levels were found when this polymorphism was analyzed [29][30][31]. This finding was confirmed because the presence of allele G in gene position -330 was correlated with reduced IL-2 production in vivo [32].…”

“…Several IL-2 gene polymorphisms are known, including those at positions -330 T/G and +114 T/G. Polymorphism -330 T/G (rs2069762) is located in the gene promoter region and is associated with increased susceptibility to inflammatory diseases and cancer, including rheumatoid arthritis and myeloid leukemia [28][29][30]. Additionally, studies show that changes in the serum IL-2 levels were found when this polymorphism was analyzed [29][30][31].…”

Interleukin-1 Receptor Antagonist VNTR Polymorphism and Ovarian Cancer Susceptibility in Tunisian Women

“…The majority of these studies have been enrolled on cancers, such as gastric [AlMoundhri, 2006;Geon Shin, 2008], bladder [Bid, 2006], breast [Lee, 2007], colorectal [Viet, 2005], cervical [Sousa, 2012;Fujiwaki, 2003], vulvar [Grimm, 2004], and ovarian [Sehouli, 2003;Hefler, 2002]. Nevertheless, there are controversial results regarding the potential role of this polymorphism in the development of cancer.…”

Interleukin 2 Gene Polymorphisms Are Associated with Non-Hodgkin Lymphoma

“…The -330T/G polymorphism lies in the promoter region of the IL-2 gene and is implicated in the increased susceptibility to a range of inflammatory diseases and cancers, including gastric atrophy from Helicobacter pylori infection, rheumatoid arthritis, gastric cancer, and myelogenous leukemia (Amirzargar et al, 2005;Pawlik et al, 2005;Togawa et al, 2005;Shin et al, 2008;Wu et al, 2009). However, no studies to date have examined the association between IL-2 polymorphisms and NHL.…”