Interleukin 2 Gene Polymorphisms Are Associated with Non-Hodgkin Lymphoma

Song, Haihan; Chen, Lei; Cha, Zhanshan; Bai, Jianwen

doi:10.1089/dna.2011.1603

Cited by 24 publications

(21 citation statements)

References 28 publications

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“…Two polymorphisms have been identified in the Chinese population. One is T to G substitution, and it is located in the promoter region at nucleotide 330 upstream from the ATG start codon [20]. The other is also T to G substitution, and it is in the first exon at position +114 [20].…”

Section: Discussionmentioning

confidence: 99%

“…One is T to G substitution, and it is located in the promoter region at nucleotide 330 upstream from the ATG start codon [20]. The other is also T to G substitution, and it is in the first exon at position +114 [20]. Researchers have presented that the −330T/G polymorphism are associated with various diseases and cancers, including gastric atrophy from Helicobacter pylori infection, rheumatoid arthritis, gastric cancer, and myelogenous leukemia [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

et al. 2013

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Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 -330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 -330GG genotype was significantly increased in CAD than in controls (p = 5.1 × 10(-6)). Function analysis revealed that subjects carrying IL-2 -330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p < 0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p < 0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p < 0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

et al. 2013

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“…PCR was performed based on previously described methods (Song et al, 2012). Primers were designed for TaqI (rs907715G/A) or BsgI (rs2221903A/G) (New England Biolabs, Beverly, MA) and are shown in Table 1.…”

Section: Dna Extraction and Genotypingmentioning

confidence: 99%

“…D iffuse large B-cell lymphoma (DLBCL) is the major type of non-Hodgkin lymphoma (NHL) (MaciasPerez and Flinn, 2012;Song et al, 2012;Bellera et al, 2013). Treatments of DLBCL have been improved in the recent years (Troppan et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Functional Interleukin-21 Polymorphism Is a Protective Factor of Diffuse Large B-Cell Lymphoma

Wang

Feng

et al. 2014

DNA and Cell Biology

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Interleukin-21 (IL-21) is a recently discovered cytokine and plays critical roles in antitumor immune responses. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. In this study, we investigated the association between IL-21 genetic polymorphisms and the susceptibility to DLBCL, and the possible functions of these polymorphisms. Two IL-21 polymorphisms, rs907715G/A and rs2221903A/G, were examined in 212 DLBCL patients and 232 healthy controls. Data showed that percentages of rs907715GA and AA genotypes were significantly lower in patients than in controls (odds ratio [OR]=0.60, 95% confidence interval [CI]: 0.40-0.90, p=0.014; OR=0.31, 95% CI: 0.17-0.56, p<0.001, respectively). Frequency of the rs2221903A/G polymorphism did not reveal any significant differences between patients and healthy donors. Further analyses demonstrated a significantly decreased number of rs907715AA genotype in patients with advanced Ann Arbor stages (III+IV). Moreover, we investigated the correlation between IL-21 polymorphisms and serum level of IL-21. Results showed that subjects carrying rs907715AA had significantly increased level of IL-21 than those with GG genotype or GA genotype. These data suggest that rs907715G/A polymorphism may act as a protective factor of DLBCL and might affect the serum level of IL-21.

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“…Single-nucleotide polymorphisms (SNPs) may be associated with various diseases [15,16]. IL-21 −2498G/A and +78A/G polymorphisms have been identified in the Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism in interleukin 21 gene is associated with decreased susceptibility to diffuse large B cell lymphoma

Mai²

2014

Tumor Biol.

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Interleukin 21 (IL-21) plays a key role in innate and adaptive immunity. Polymorphisms in IL-21 gene may be greatly involved in various diseases. The aim of the study was to investigate the association between IL-21 genetic polymorphisms and the susceptibility to diffuse large B cell lymphoma (DLBCL). IL-21 -2498G/A and +78A/G polymorphisms were examined in 221 DLBCL patients and 243 healthy controls. We found that distributions of -2498GA genotype and -2498AA genotype were clearly decreased in DLBCL cases compared to healthy donors (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.43-0.92, P = 0.021; OR = 0.36, 95 % CI = 0.15-0.48, P < 0.001; data were adjusted for age and sex). Stratification analyses revealed that patients with advanced Ann Arbor stages (III+IV) had further decreased percentage of -2498AA genotype than those with primary stages (OR = 0.31, 95% CI = 0.13-0.87, P = 0.023; data were adjusted for age and sex). In addition, we evaluated the possible effect of IL-21 polymorphisms on gene expression by examining serum level of IL-21 in patients and controls. Data revealed that subjects carrying -2498AA genotype had significantly higher serum level of IL-21 than those with GG genotype or GA genotype. These data suggest that IL-21 -2498G/A polymorphism is associated with decreased susceptibility to DLBCL and may increase serum level of IL-21.

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Interleukin 2 Gene Polymorphisms Are Associated with Non-Hodgkin Lymphoma

Cited by 24 publications

References 28 publications

Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

Functional Interleukin-21 Polymorphism Is a Protective Factor of Diffuse Large B-Cell Lymphoma

Polymorphism in interleukin 21 gene is associated with decreased susceptibility to diffuse large B cell lymphoma

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