Polymorphism in interleukin 21 gene is associated with decreased susceptibility to diffuse large B cell lymphoma

Abstract

Interleukin 21 (IL-21) plays a key role in innate and adaptive immunity. Polymorphisms in IL-21 gene may be greatly involved in various diseases. The aim of the study was to investigate the association between IL-21 genetic polymorphisms and the susceptibility to diffuse large B cell lymphoma (DLBCL). IL-21 -2498G/A and +78A/G polymorphisms were examined in 221 DLBCL patients and 243 healthy controls. We found that distributions of -2498GA genotype and -2498AA genotype were clearly decreased in DLBCL cases compared to healthy donors (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.43-0.92, P = 0.021; OR = 0.36, 95 % CI = 0.15-0.48, P < 0.001; data were adjusted for age and sex). Stratification analyses revealed that patients with advanced Ann Arbor stages (III+IV) had further decreased percentage of -2498AA genotype than those with primary stages (OR = 0.31, 95% CI = 0.13-0.87, P = 0.023; data were adjusted for age and sex). In addition, we evaluated the possible effect of IL-21 polymorphisms on gene expression by examining serum level of IL-21 in patients and controls. Data revealed that subjects carrying -2498AA genotype had significantly higher serum level of IL-21 than those with GG genotype or GA genotype. These data suggest that IL-21 -2498G/A polymorphism is associated with decreased susceptibility to DLBCL and may increase serum level of IL-21.

The association between interleukin‐21 (rs2055979G/T) gene polymorphism and the risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus

“…11 Its genetic changes are related with the risk of autoimmune diseases, 17,18 and several tumors involving breast cancer, diffuse large B lymphoma, thyroid cancer, non small-cell lung cancer (NSCLC), and hepatitis B virus (HBV)related HCC. [19][20][21][22][23] However, no study so far has reported the association between IL-21 polymorphisms and the hazard of HCC in patients with hepatitis C virus (HCV). Accordingly, the aim of the current research literature was to elucidate the potential impact of two IL-21 polymorphisms (rs2221903A/G and rs2055979G/T) on the hazard of HCC progression and metastasis in HCV infected Egyptian patients, and to clarify whether these single-nucleotide polymorphisms (SNPs) affect clinical profiles of the disease.…”

“…11 Its genetic changes are related with the risk of autoimmune diseases, 17,18 and several tumors involving breast cancer, diffuse large B lymphoma, thyroid cancer, non small-cell lung cancer (NSCLC), and hepatitis B virus (HBV)related HCC. [19][20][21][22][23] However, no study so far has reported the association between IL-21 polymorphisms and the hazard of HCC in patients with hepatitis C virus (HCV).…”