Polymorphisms in the leptin ( rs7799039 ) gene are associated with an increased risk of excessive gestational weight gain but not with leptin concentration during pregnancy

Martins, Maisa Cruz; Trujillo, Janet; Farias, Dayana Rodrigues; Kac, Gilberto

doi:10.1016/j.nutres.2017.09.003

Cited by 18 publications

(19 citation statements)

References 32 publications

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“…On the contrary, 2548GG+GA showed a positive increase in systemic blood pressure in early pregnancy. In a more recent study, the 2548A allele was associated with an increased risk for gestational weight gain (Martins et al, 2017). The influence of G2548A SNP in leptin levels during pregnancy is still not evident (Sugathadasa et al, 2010; Yang et al, 2016; Farias et al, 2017).…”

Section: Gene Variants Involved In Metabolic Processesmentioning

confidence: 97%

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Michita

Kaminski

2018

Front. Physiol.

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Placental vascularization is a tightly regulated physiological process in which the maternal immune system plays a fundamental role. Vascularization of the maternal-placental interface involves a wide range of mechanisms primarily orchestrated by the fetal extravillous trophoblast and maternal immune cells. In a healthy pregnancy, an immune cross-talk between the mother and fetal cells results in the secretion of immunomodulatory mediators, apoptosis of specific cells, cellular differentiation/proliferation, angiogenesis, and vasculogenesis, altogether favoring a suitable microenvironment for the developing embryo. In the context of vasculopathy underlying common pregnancy disorders, it is believed that inefficient invasion of extravillous trophoblast cells in the endometrium leads to a poor placental blood supply, which, in turn, leads to decreased secretion of angiogenic factors, hypoxia, and inflammation commonly associated with preterm delivery, intrauterine growth restriction, and preeclampsia. In this review, we will focus on studies published by Latin American research groups, providing an extensive review of the role of genetic variants from candidate genes involved in a broad spectrum of biological processes underlying the pathophysiology of preeclampsia. In addition, we will discuss how these studies contribute to fill gaps in the current understanding of preeclampsia. Finally, we discuss some trending topics from important fields associated with pregnancy vascular disorders (e.g., epigenetics, transplantation biology, and non-coding RNAs) and underscore their possible implications in the pathophysiology of preeclampsia. As a result, these efforts are expected to give an overview of the extent of scientific research produced in Latin America and encourage multicentric collaborations by highlighted regional research groups involved in preeclampsia investigation.

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Section: Gene Variants Involved In Metabolic Processesmentioning

confidence: 97%

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Michita

Kaminski

2018

Front. Physiol.

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“…Perhaps a direct effect of leptin on lipid oxidation could also be implied ( 22 ) . However, a recent study in pregnant women ( 23 ) showed how this SNP can affect weight gain during pregnancy, although it did not modify the concentration of circulating leptin. Therefore, an indirect effect through leptin does not appear to be possible.…”

Section: Discussionmentioning

confidence: 93%

Leptin gene polymorphism (rs 7799039;G2548A) is associated with changes in lipid profile during a partial meal‐replacement hypocaloric diet

Primo

Izaola

Luis

2020

J Human Nutrition Diet

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“…Another study has shown that LEP rs7799039 is significantly associated with increased risk for gestational weight gain. Thus it may affect other weight related diseases among females 24 .…”

Section: Discussionmentioning

confidence: 99%

Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population

Wang

Han

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Leptin (LEP) is a peptide hormone that acts via leptin receptor (LEPR) binding. Genetic evidence from different human populations has implicated LEP/LEPR in the pathogenesis of coronary artery disease (CAD), and suggests that certain LEP/LEPR gene polymorphisms may increase the risk of CAD. The aim of this study was to assess two single nucleotide polymorphisms (SNPs) in LEP genes (rs2167270 and rs7799039) and two in LEPR genes (rs6588147, rs1137100) for association with CAD. Methods: We enrolled 271 North Chinese Han CAD patients, and 113 healthy age-and sex-matched controls. Genomic DNA was extracted from whole blood, and the four SNPs were assessed using a MassArray system. Results: The G allele frequency at rs2167270 was significantly higher among CAD cases than among controls. The AG genotype at rs7799039 was associated with a significantly decreased risk of CAD unlike the AA genotype used as the reference. The A allele was significantly associated with the CAD patient group. Interestingly, statistically significant differences in genotype and allele frequency at LEP rs2167270 and rs7799039 existed among females but not among males. Conclusions: The current study detected a significant association between genetic variations at LEP rs7799039 and rs2167270 and the risk of CAD in a north Chinese population, and revealed that LEP rs2167270 and rs7799039 gene polymorphisms might act as predisposing factors for CAD.

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Polymorphisms in the leptin ( rs7799039 ) gene are associated with an increased risk of excessive gestational weight gain but not with leptin concentration during pregnancy

Cited by 18 publications

References 32 publications

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Genetic Variants in Preeclampsia: Lessons From Studies in Latin-American Populations

Leptin gene polymorphism (rs 7799039;G2548A) is associated with changes in lipid profile during a partial meal‐replacement hypocaloric diet

Association of leptin and leptin receptor polymorphisms with coronary artery disease in a North Chinese Han population

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