Leptin gene polymorphism (rs 7799039;G2548A) is associated with changes in lipid profile during a partial meal‐replacement hypocaloric diet

Primo, David; Izaola, Olatz; Luis, Daniel Antonio de

doi:10.1111/jhn.12809

Cited by 5 publications

(2 citation statements)

References 22 publications

(35 reference statements)

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“…A limitation in this context is that only serum leptin concentrations had been measured. Genetic information might have offered further insight since it had been shown that polymorphisms of the leptin receptor gene are able to inhibit the decrease of serum leptin levels during dietary intervention [39] and are associated with blood lipids [40]. Therefore, we could just speculate about potential mechanisms, especially in other tissues.…”

Section: Discussionmentioning

confidence: 99%

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

et al. 2022

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Lifestyle interventions including meal replacement are suitable for prevention and treatment of obesity and type-2-diabetes. Since leptin is involved in weight regulation, we hypothesised that a meal replacement-based lifestyle intervention would reduce leptin levels more effectively than lifestyle intervention alone. In the international, multicentre, randomised-controlled ACOORH-trial (Almased-Concept-against-Overweight-and-Obesity-and-Related- Health-Risk), overweight or obese participants with metabolic syndrome criteria (n = 463) were randomised into two groups and received telemonitoring devices and nutritional advice. The intervention group additionally used a protein-rich, low-glycaemic meal replacement. Data were collected at baseline, after 1, 3, 6, and 12 months. All datasets providing leptin data (n = 427) were included in this predefined subanalysis. Serum leptin levels significantly correlated with sex, body mass index, weight, and fat mass at baseline (p < 0.0001). Stronger leptin reduction has been observed in the intervention compared to the control group with the lowest levels after 1 month of intervention (estimated treatment difference −3.4 µg/L [1.4; 5.4] for females; −2.2 µg/L [1.2; 3.3] for males; p < 0.001 each) and was predictive for stronger reduction of body weight and fat mass (p < 0.001 each) over 12 months. Strongest weight loss was observed after 6 months (−5.9 ± 5.1 kg in females of the intervention group vs. −2.9 ± 4.9 kg in the control group (p < 0.0001); −6.8 ± 5.3 kg vs. −4.1 ± 4.4 kg (p = 0.003) in males) and in those participants with combined leptin and insulin decrease. A meal replacement-based lifestyle intervention effectively reduces leptin which is predictive for long-term weight loss.

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Section: Discussionmentioning

confidence: 99%

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

et al. 2022

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“…Gene polymorphism is demonstrated to be associated with the biomedical functions of MR. Leptin gene polymorphism (rs 7799039; G2548A) and RS9939609 FTO gene variant are associated with weight loss, insulin resistance, and lipid profile alterations after a low-calorie MR diet [75][76] . ACYL-CoA synthetase long-chain 5 polymorphism also correlates with weight loss and metabolic benefits in response to a low-calorie MR diet [77] .…”

Section: Other Mechanismsmentioning

confidence: 99%

A comprehensive review of meal&ensp;replacement from dining table to sickbed: beyond biomedical potentials

Qiang,

Xu,

et al. 2024

Food Science and Human Wellness

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The emergence of meal replacement (MR) originates from physical exercise or fitness as a substitute for one or all meals and later expands to the field of weight loss. Indeed, the main application of current meal replacement is to lose body weight, whether patients with obesity, diabetes, fatty liver, infertile or pregnant women can benefit from weight loss. In addition, MRs still exhibit more biomedical potential in preventing and treating diseases, like anti-diabetes, improving fatty liver and kidney disease, preventing cancer, conceiving and reducing pregnancy complications, and improving life quality. Indeed, there are also disadvantages to meal replacement, including causing adverse effects, although most are acceptable and tolerated. To date, various commercially-developed MRs are walking from dining table to sickbed. Therefore, a scientific understanding of the advantages and disadvantages of meal replacements is crucial for their extensive application beyond biomedical potentials.

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The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran

Azimnasab-Sorkhabi

Soltani-Asl

Kfoury

et al. 2022

Annals of Human Biology

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Leptin gene polymorphism (rs 7799039;G2548A) is associated with changes in lipid profile during a partial meal‐replacement hypocaloric diet

Abstract: How to cite this article Primo D., Izaola O. & de Luis D. (2021) Leptin gene polymorphism (rs 7799039;G2548A) is associated with changes in lipid profile during a partial meal-replacement hypocaloric diet.

Cited by 5 publications

References 22 publications

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

Early and Strong Leptin Reduction Is Predictive for Long-Term Weight Loss during High-Protein, Low-Glycaemic Meal Replacement—A Subanalysis of the Randomised-Controlled ACOORH Trial

A comprehensive review of meal&ensp;replacement from dining table to sickbed: beyond biomedical potentials

The impact of leptin and its receptor polymorphisms on type 1 diabetes in a population of northwest Iran

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