Polymorphisms in the GSTT1 and GSTM1 genes are associated with increased risk of preeclampsia in the Mexican mestizo population

Abstract

ABSTRACT. Preeclampsia is a pregnancy-specific disorder in humans and a major cause of maternal and neonatal morbidity and mortality. Increasing evidence suggests that oxidative stress plays an important role in the pathogenesis of preeclampsia. The aim of this study was to investigate the relationship between null alleles of the glutathione S-transferases (GST) M1 and T1 genes and the risk of preeclampsia. This case-control study involved 112 preeclamptic and 233 normoevolutive pregnant women. The null polymorphisms were 2161 GSTT1/GSTM1 null polymorphisms and preeclampsia ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (1): 2160-2165 (2014) genotyped by multiplex polymerase chain reaction (PCR). Our results showed an increased risk of preeclampsia in patients with the GSTT1 null genotype [odds ratio (OR) = 2.21; 95% confidence interval (CI) = 1.14-4.27; P = 0.018]. Our data further showed that a combination of deletion genotypes of the GSTM1 and GSTT1 genes conferred an even higher risk of preeclampsia (OR = 4.56, 95%CI = 1.59-13.09; P = 0.005). Our results provide the first evidence suggesting that a GSTT1 null polymorphism might be associated with preeclampsia in the Mexican mestizo population, and that this risk increases with the combination of both GSTT1 and GSTM1 null polymorphisms.

Association of the GSTM1 null polymorphism with breast cancer in a Mexican population

“…In the present study, we observed similar null GSTM1 genotype frequencies in our control group at those that had been previously reported in Mexico (Pérez-Morales et al, 2011;Martínez-Ramírez et al, 2013;Sandoval-Carrillo et al, 2014). The genotypic GSTM1 null frequencies were 38 and 45% in the control group and in patients with BC, respectively, suggesting an association of this allele as a risk factor in BC.…”

“…Several reports in the general Mexican population have described a high frequency of the null GSTM1 allele of approximately of 37-44%, depending on the tested region (Pérez-Morales et al 2011;Martinez-Ramirez et al, 2013;Sandoval-Carrillo et al, 2014). However, there are no descriptions to date of an association of the null GSTM1 polymorphism with BC in Mexican women.…”

GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions

“…Since the pivotal role of GST enzymes in the mechanisms related to antioxidant defense and cellular detoxification, a number of studies investigated the role of GST genetic variations in oxidative stress-related diseases [11,12]. Regarding GH, some research groups focused on the role of deletion polymorphisms of the GSTT1 and GSTM1 genes affecting the risk of preeclampsia, obtaining disagreeing results [13,14]. However, the biochemical investigation of GST levels confirmed the significant dyshomeostasis of GST systems in preeclampsia:…”

Association of glutathione S‐transferase theta 1 and glutathione S‐transferase mu 1 gene polymorphism with the risk of pre‐eclampsia during pregnancy in Bangladesh

“…They also found no association between GSTM1 gene polymorphism and pre‐eclampsia. Study conducted by Sandoval‐Carrillo et al . found a significant relation with GSTT1 null genotype and the risk of pre‐eclampsia in Mexican mestizo population.…”

“…found significant relationship between GSTT1 null genotype with pre‐eclampsia in the Chinese population. Another study on Mexican population showed higher risk of developing pre‐eclampsia in patients having GSTT1 null genotype and even higher risk for GSTT1 and GSTM1 combined null genotype . Another study on Iranian population revealed that there was no association of GSTT1 and GSTM1 gene polymorphism with pre‐eclampsia .…”