Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer

Ruzzo, Annamaria; Canestrari, Emanuele; Maltese, Paolo Enrico; Pizzagalli, Francesca; Graziano, Francesco; Santini, Daniele; Catalano, Vincenzo; Ficarelli, R.; Mari, D.; Bisonni, Renato; Giordani, Paolo; Giustini, Lucio; Lippe, P.; Silva, Rosarita; Mattioli, Rodolfo; Torresi, U.; Latini, Luciano; Magnani, Mauro

doi:10.1515/cclm.2007.143

Cited by 55 publications

(32 citation statements)

References 52 publications

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“…Hence, data were available from 8 case-control studies, including 1334 gastric cancer cases and 2194 controls (Table 1) [8,[10][11][12][13][14][15][16] . We established a database according to the extracted information from each article.…”

Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

Geng¹,

Zhang²,

Huang³

et al. 2008

WJG

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AIM:To evaluate the association between X-ray crosscomplementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of metaanalysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our selection criteria. Statistical analysis was performed with the software program Review Manage, version 4.2.8. RESULTS: Of the 8 case-control studies selected for this meta-analysis, a total of 1334 gastric cancer cases and 2194 controls were included. For Arg399Gln, the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR = 0.92, 95% CI, 0.71-1.19; P = 0.51). Similarly, no associations were found in the recessive and dominant modeling (Gln/Gln vs Arg/Gln + Arg/Arg: OR = 0.96; 95% CI, 0.77-1.19; P = 0.70 and Gln/Gln + Arg/Gln vs Arg/Arg: OR = 0.90, 95% CI, 0.77-1.05; P = 0.18). CONCLUSION:No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.

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Section: Literature Search and Meta-analysis Databasesmentioning

confidence: 99%

XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

Geng¹,

Zhang²,

Huang³

et al. 2008

WJG

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“…13 articles were excluded after reading the full text. Six were not Asians studies (Gonzalez et al, 2004;Martinez et al, 2006;Ruzzo et al, 2007;Wideroff et al, 2007;Zendehdel et al, 2009; Garcia-Gonzalez et al, 2012), and seven were repeating or overlapping publications (Cai et al, 1999;Setiawan et al, 2001; Gao et al, 2002b;Qian et al, 2003; Sheng et al, 2004;Nan et al, 2005b;Tripathi et al, 2008). Finally, 39 articles that report on the effects of GSTT1 polymorphisms on gastric cancer in Asia covering in total of 7,737 gastric cancer cases and 10,823 controls were remained for data extraction.…”

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confidence: 99%

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Zeng

Bai²,

Deng³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: A large number of studies have been published to investigate the association between the null genotype of glutathione S-transferase T1 (GSTT1) with gastric cancer. However, the results were inconsistent and conflicting. The aim of this study was to estimate the relationship between this polymorphism in the GSTT1 gene and gastric cancer risk in Asian populations by meta-analysis. Materials and Methods: A literature search was performed in PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang database, and China National Knowledge Infrastructure database (CNKI). Statistical analysis was conducted by using Review Manager 5.3. Results: Thirty-nine studies with a total of 7,737 gastric cancer cases and 10,823 controls were included in this meta-analysis. The meta-analysis of total studies showed that the null genotype in GSTT1 was associated with increased risk of gastric cancer in Asians (OR=1.19, 95% CI=1.08-1.31, p=0.0002). Subgroup analysis showed a significant relationship between GSTT1 null genotype and gastric cancer in East-Asians, as well as in subgroup analysis of hospital-based design. On subgroup analysis by smoking status, alcohol status, Helicobacter pylori infection status, and histology type, no significant association of this polymorphism with susceptibility to gastric cancer was found. Conclusions: In conclusion, the results showed that the null genotype of GSTT1 is significantly associated with an increased risk in gastric cancer in Asian populations. (Acar et al., 2006;Sreeja et al., 2008;Liu et al., 2010). Polymorphisms in this gene affect the enzymatic activities and the ability to metabolize carcinogenic compounds (Nebert et al., 1999). The most common variant of GSTT1 gene is homozygous deletion (null genotype), which has been reported to be associated with gastric cancer (Hayes and Strange, 2000). However, the sparseness of data or disagreements among the reported investigations results in the available evidence weakly. To assess the effect of GSTT1 null genotype on gastric cancer risk in Asian population more precisely, we conducted most of the related studies and performed this meta-analysis of published data investigating whether the null genotype of GSTT1 gene was associated with the risk of gastric cancer. Keywords Materials and Methods Publication searchA literature search of PubMed, Embase, Chinese Biomedical database (CBM), Weipu database, Wanfang 1142database and Chinese National Knowledge Infrastructure (CNKI) was conducted using combinations of the following keywords: "gastric cancer or gastric carcinoma or gastric neoplasm" and "polymorphism or variant or mutation" and "GSTT1 or glutathione S-transferase T1". The language was limited to Chinese and English. All studies that evaluate the relationship between polymorphisms in GSTT1 gene and gastric cancer risk were retrieved. Studies included in the meta-analysis had to meet all of the following criteria: (1) evaluation of the polymorphisms in GSTT1 gene and gastric cancer risk, (2) use of ...

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“…Only an Italian report demonstrated that GSTP1 G/G genotypes were associated with a reduced risk of the diffuse type of GC in H. pylori negative subjects. 38 In the present study, stratification of H. pylori infection was performed, and the GSTP1 G/G genotype was found to be significantly higher in the H. pylori-positive AGC group, particularly with the intestinal type; however, not in the H. pylori negative AGC group. These findings suggest that a patient with the G/G genotype of GSTP1 might be more susceptible to the development of the intestinal type of AGC in the presence of H. pylori infection.…”

mentioning

confidence: 51%

Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer

Kang¹,

Kim²,

Cho³

et al. 2008

Gut Liver

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Background/Aims: Glutathione S-transferase P1 (GSTP1) scavenges radicals via its peroxidase activity. The purpose of this study was to determine the association of GSTP1 genetic polymorphisms with the expression of H. pylori-associated gastroduodenal disease. Methods: This study involved 1,911 subjects, comprising patients with four diseases (gastric cancer, dysplasia, benign gastric ulcer, and duodenal ulcer disease) and controls. Biallelic polymorphisms were genotyped by restriction fragment length polymorphism techniques. Results: The frequency of the genetic polymorphism at nucleotide 313 of GSTP1 did not differ among the five study groups. However, when the gastric cancer group was subdivided into advanced gastric cancer (AGC) and early gastric cancer, the frequency of the G/G genotype was significantly higher in the AGC group than in all the control subgroups (OR: 1.2, 95% CI: 1.1-4.9). The frequency of this genotype differed significantly in the H. pylori-positive AGC group (OR: 2.7, 95% CI: 1.1-6.3) but not in the H. pylori-negative group. Furthermore, the difference was greater in the intestinal type, and was not found in diffuse types of disease. Conclusions: This study found that genetic polymorphisms of GSTP1 were associated with H. pylori-associated gastric cancer only during the advanced stage of gastric cancer, with intestinal-type histology evident in H. pylori-positive subjects. (Gut and Liver 2008;2:23-29)

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Polymorphisms in genes involved in DNA repair and metabolism of xenobiotics in individual susceptibility to sporadic diffuse gastric cancer

Abstract: This study suggests that GSTP1 105A/G and GSTT1-null/positive genotypes might be associated with a reduced risk for sporadic diffuse gastric cancer. Clin Chem Lab Med 2007;45:822-8.

Cited by 55 publications

References 52 publications

XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

Association of the Glutathione S-transferase T1 Null Genotype with Risk of Gastric Cancer: a Meta-analysis in Asian Populations

Effects of Genetic Polymorphisms of Glutathione S-transferase P1 on Helicobacter pylori-associated Gastric Cancer

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