XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis

Abstract

AIM:To evaluate the association between X-ray crosscomplementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of metaanalysis. METHODS:We searched PubMed and NCBI up to June 1, 2008. A total of 16 clinical trials and reports were identified, but only 8 trials qualified under our selection criteria. Statistical analysis was performed with the software program Review Manage, version 4.2.8. RESULTS: Of the 8 case-control studies selected for this meta-analysis, a total of 1334 gastric cancer cases and 2194 controls were included. For Arg399Gln, the Gln/Gln genotype carriers did not have a decreased cancer risk compared with those individuals with the Arg/Arg genotype (OR = 0.92, 95% CI, 0.71-1.19; P = 0.51). Similarly, no associations were found in the recessive and dominant modeling (Gln/Gln vs Arg/Gln + Arg/Arg: OR = 0.96; 95% CI, 0.77-1.19; P = 0.70 and Gln/Gln + Arg/Gln vs Arg/Arg: OR = 0.90, 95% CI, 0.77-1.05; P = 0.18). CONCLUSION:No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.

The XRCC1 Arg399Gln Genetic Polymorphism Contributes to Hepatocellular Carcinoma Susceptibility: An Updated Meta-analysis

“…XRCC1 polymorphisms contribute to carcinogenesis, such as lung cancer (Kiyohara et al, 2006), breast cancer (Saadat et al, 2009), and prostate cancer (Geng et al, 2009). Oppositely, it seems that XRCC1 polymorphisms didn't exert influence on the development of gastric cancer (Geng et al, 2008), bladder cancer , and colorectal cancer . Regarding to HCC, the correlations between XRCC1 polymorphisms and HCC susceptibility were also conflicting.…”

XRCC1 Arg399Gln Gene Polymorphism and Hepatocellular Carcinoma Risk in the Chinese Han Population: A Meta-analysis

“…To date, XRCC1 Arg399Gln gene polymorphism has been shown to be linked to susceptibility to gastric cancer,colorectal cancer, lung cancer and breast cancer (Dufloth et al, 2005;Geng et al, 2008;Wu et al, 2011;Cui et al, 2012;Liu et al, 2012), and several case-control studies have inves¬tigated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk. How¬ever, with relatively small sample sizes, these former studies provided limited informa¬tion and could not draw a convincing conclusion.…”

“…These nonconservative amino acid changes may alter XRCC1 function. This change in protein biochemistry leads to the supposition that variant alleles may diminish repair kinetics, thereby influencing susceptibility to adverse health effects, including cancer (Geng et al, 2008).…”

Evaluation of DNA Repair Gene XRCC1 Polymorphism in Prediction and Prognosis of Hepatocellular Carcinoma Risk

“…Several studies have explored the impact of XRCC1-Arg399Gln polymorphism in various cancers including lung, gastric, esophageal, breast, prostate and glioma cancers (Geng et al, 2008;Yin et al, 2009;Kiyohara et al, 2010;Rajaraman et al, 2010;Zipprich et al, 2010). However, association studies of XRCC1-Arg399Gln polymorphism in HCC risk have been conflicting (Kiran et al, 2009;Liu et al, 2011).…”