Polymorphisms at the Osteoprotegerin and Interleukin-6 Genes in Relation to First-Ever Stroke

Strand, Magnus; Söderström, Ingegerd; Wiklund, Per-Gunnar; Hallmans, Göran; Weinehall, Lars; Söderberg, Stefan; Olsson, Tommy

doi:10.1159/000108431

Cited by 23 publications

(17 citation statements)

References 82 publications

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“…33 In another interesting study researchers assessed the potential role of estrogen signaling on this association through putative target genes (osteoprotegerin and interleukin-6); carriers of the osteoprotegerin-1181C/C genotype had a significantly increased risk of intracerebral hemorrhage (P=0.005). 34 This implies that alterations in osteoprotegerin-mediated signaling in the vasculature may be involved in the pathophysiology of hemorrhagic stroke. There have also been a number of studies on the effect of statins on bone mass.…”

Section: Strokementioning

confidence: 99%

Bone Mineral Density and Incidence of Stroke

Myint

Clark

Kwok

et al. 2014

Stroke

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Background and Purpose-The prospective link between osteoporosis and future risk of stroke requires evidence from large-scale population-based long-term studies. Methods-Calcaneum broadband ultrasound attenuation was measured in the Norfolk cohort of the European Prospective Investigation into Cancer-Norfolk between 1997 and 2000. Incident strokes were ascertained by hospital record linkage and death certificates in March 2009 and December 2011, respectively. A search of MEDLINE and EMBASE was performed to evaluate the relationship between bone mineral density and incident stroke. After data extraction of relevant studies, pooled risk of stroke was estimated using meta-analysis. Results-In 14 290 participants (mean follow-up of 9.3 years; total person-years 132 574), there were 599 incident strokes.Participants in the lowest 10% of the calcaneum broadband ultrasound attenuation distribution had an increased stroke risk (hazard ratio 1.41; 95% confidence intervals, 1.02-1.94) compared with those in the top 30% of the distribution after adjustments. A decrease of ~1 standard deviation in broadband ultrasound attenuation (20 db/MHz) was associated with a 17% increase in relative risk of stroke (95% confidence intervals, 5%-30%). Meta-analysis of 4 studies (25 760 participants, 1237 cases of stroke) found that for every decrease in 1 standard deviation in bone mineral density, there was an increased risk of incident stroke among women (pooled relative risk 1.22; 95% confidence intervals, 1.09-1.37; I 2 =0%, 3 studies) but not in men (pooled relative risk 1.05; 95% confidence intervals, 0.94-1.17; I 2 =0%, 2 studies). Conclusions-Bone mineral density predicts total stroke risk. The evidence is stronger in women with regard to the continuous relationship. (Stroke. 2014;45:373-382.)

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Section: Strokementioning

confidence: 99%

Bone Mineral Density and Incidence of Stroke

Myint

Clark

Kwok

et al. 2014

Stroke

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“…Previous investigations have demonstrated a significant association between the -174G/C (rs1800795) polymorphism and risk of ischemic stroke, but their results have been inconsistent (Lalouschek et al, 2006;Strand et al, 2007;Yang et al, 2014;Bazina et al, 2015). Bazina et al (2015) conducted a study with 144 ischemic stroke patients and 187 healthy controls, and identified a significant link between this polymorphism and an increased risk of ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Association between IL6 polymorphism and risk of cerebral infarction

Han

2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. This study included 305 cerebral infarction patients and 326 control subjects enrolled between May 2012 and May 2014. The genotyping of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. By using logistic regression, we found that when compared with the wildtype genotype, CC and GC+CC IL6 -174G/C (rs1800795) genotypes were associated with an increased risk of cerebral infarction. Odds ratios (and 95% confidence intervals) were calculated to be 3.10 (1.57-6.41) and 1.63 (1.14-2.33) for the CC and GC+CC genotypes, respectively. In conclusion, our study suggests that the CC genotype and C allele of the IL6 -174G/C (rs1800795) polymorphism are associated with an increased risk of cerebral infarction.

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“…2005; Strand et al. 2007), OPG also served as a vascular calcification inhibitor (Clancy et al. 2006).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in three genes are associated with hemorrhagic stroke

Liu

Ge²,

Liu

et al. 2015

Brain and Behavior

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BackgroundMultiligand receptor for advanced glycation end products (RAGE), osteoprotegerin, and Golgb1 genes may be implicated in atherosclerosis and vascular diseases. Single nucleotide polymorphisms (SNPs) rs1035798 in RAGE gene, rs2073617 and rs2073618 in TNFRSF11B, and rs3732410 in Golgb1 will be investigated on whether there is an association with hemorrhagic stroke (HS) in Chinese population.MethodsA total of 600 subjects including 199 HS patients and 401 controls were assayed. These samples were divided into two groups: the ≤50 year and >50 year groups. Genotyping of SNPs was determined using the SEQUENOM MassARRAY matrix‐assisted laser desorption ionization–time‐of‐flight–mass spectrometry. The association between genotype and HS risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) with multivariate unconditional logistic regression analyses.ResultsOur data showed that in the ≤50 year group, the rs1035798 major allele homozygote C/C in RAGE gene was associated with an increased risk of HS, while Golgb1 rs3732410 minor allele homozygote G/G was associated with a decreased risk of HS. In the >50 year group, the major allele homozygote G/G of rs2073618 was found to be associated with an increased risk of HS.ConclusionsThe polymorphisms rs1035798 of RAGE gene, rs2073618 of TNFRSF11B, and rs3732410 of Golgb1 might be involved in the risk of HS at different stage of ages.

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Polymorphisms at the Osteoprotegerin and Interleukin-6 Genes in Relation to First-Ever Stroke

Cited by 23 publications

References 82 publications

Bone Mineral Density and Incidence of Stroke

Bone Mineral Density and Incidence of Stroke

Association between IL6 polymorphism and risk of cerebral infarction

Polymorphisms in three genes are associated with hemorrhagic stroke

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