Association between IL6 polymorphism and risk of cerebral infarction

Abstract

ABSTRACT. We conducted a case-control study to investigate the influence of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) genetic variants on the development of cerebral thrombosis in a Chinese population. This study included 305 cerebral infarction patients and 326 control subjects enrolled between May 2012 and May 2014. The genotyping of IL6 -174G/C (rs1800795) and -572C/G (rs1800796) polymorphisms was performed using polymerase chain reaction combined with restriction fragment length polymorphism analysis. By using logistic regression, we found that when compared with the wildtype genotype, CC and GC+CC IL6 -174G/C (rs1800795) genotypes were associated with an increased risk of cerebral infarction. Odds ratios (and 95% confidence intervals) were calculated to be 3.10 (1.57-6.41) and 1.63 (1.14-2.33) for the CC and GC+CC genotypes, respectively. In conclusion, our study suggests that the CC genotype and C allele of the IL6 -174G/C (rs1800795) polymorphism are associated with an increased risk of cerebral infarction.

The SNPs rs429358 and rs7412 of APOE gene are association with cerebral infarction but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene in southern Chinese Hakka population

“…The risk of CI may vary according to the presence of various genetic and environmental factors. In addition, the relationship between the functional variation of multiple gene in different ethnic groups and CI risk has been studied, including the polymorphisms of interleukin-6 gene [ 2 ], β-fibrinogen gene [ 3 ], PON1 hypermethylation and PON3 hypomethylation [ 4 ], 5-lipoxygenase-activating protein gene association (ALOX5AP) [ 5 ], the cytochrome P450 1A1 (CYP1A1) gene [ 6 ], the human scavenger receptor class B type I (SR-BI) gene [ 7 ], genes associated with lipid metabolism [ 8 , 9 ], and others [ 10 ]. In general, it is important for both risk prediction and prevention of CI by identifying genetic risk.…”

Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application

“…The results of the abovementioned studies indicate that role of IL-6 in the pathomechanism of inflammatory response in various forms of cerebral infarction could be more complex than previously assumed and confirm the need for further studies, both in the experimental models and clinical settings. The relationship between IL-6 gene polymorphism and increased risk of cerebral infarction has been suggested [176,177], although this was not confirmed by the other published results and further studies of this issue are required [178].…”

Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study

“…It has been shown that SNPs of IL-6 may influence the development of cardiovascular disease, 28 cancer, 29 30 fractures 31 and autoimmune diseases. [32][33][34] In contrast, there is less available research regarding TIE2 gene polymorphisms, except for a study on the relationship between rs638203/rs639225 and vascular malformations.…”

“…A study reported its association with venous malformation and presumed that this polymorphism might cause abnormal splicing of TIE2 into a defective protein. 28 Functional validation of this polymorphism is warranted in the future.…”