Polymorphisms in three genes are associated with hemorrhagic stroke

Abstract

BackgroundMultiligand receptor for advanced glycation end products (RAGE), osteoprotegerin, and Golgb1 genes may be implicated in atherosclerosis and vascular diseases. Single nucleotide polymorphisms (SNPs) rs1035798 in RAGE gene, rs2073617 and rs2073618 in TNFRSF11B, and rs3732410 in Golgb1 will be investigated on whether there is an association with hemorrhagic stroke (HS) in Chinese population.MethodsA total of 600 subjects including 199 HS patients and 401 controls were assayed. These samples were divided into two groups: the ≤50 year and >50 year groups. Genotyping of SNPs was determined using the SEQUENOM MassARRAY matrix‐assisted laser desorption ionization–time‐of‐flight–mass spectrometry. The association between genotype and HS risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) with multivariate unconditional logistic regression analyses.ResultsOur data showed that in the ≤50 year group, the rs1035798 major allele homozygote C/C in RAGE gene was associated with an increased risk of HS, while Golgb1 rs3732410 minor allele homozygote G/G was associated with a decreased risk of HS. In the >50 year group, the major allele homozygote G/G of rs2073618 was found to be associated with an increased risk of HS.ConclusionsThe polymorphisms rs1035798 of RAGE gene, rs2073618 of TNFRSF11B, and rs3732410 of Golgb1 might be involved in the risk of HS at different stage of ages.

ALDH2 rs671 Polymorphism Likely a Risk Factor for Hemorrhagic Stroke: A Hospital-Based Study

“… 19 The interaction of matrix metalloproteinase-9 (MMP-9) gene polymorphisms may be related to the wind direction of hemorrhagic stroke. 20 APOE , 21 RAGE, TNFRSF11B, Golgb1 , 22 LPL , 23 CRP , 24 KCNK17 25 polymorphisms, and some microRNAs 26 also play a role in hemorrhagic stroke. However, other studies have failed to find a link between genetic variants and hemorrhagic stroke in different populations.…”

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“…The opposite results were found regarding rs1035798 (C>T), where serum RAGE and CRP levels in patients carrying homozygote CC genotype were significantly higher than in patients having mutant CT+TT genotype (Table 4). It has been hypothesized that the presence of the SNP's minor T allele interferes with splicing factor recognition [52], leading to RAGE upregulation. Our study reveals that the mutant T allele of rs1035798 (C>T) has a protective effect, that is in agreement with the other studies that showed that this variant has a protective effect in different settings [53].…”

The Relation between RAGE Polymorphism and Cardiovascular Diseases: A Review

“…31 However, the variant is relatively uncommon and even when we analyzed the Framingham offspring cohort, we were unable to identify any associations of this variant with cardiovascular disease. 32 Outside of the coding region, it is likely that variants in the promoter of RAGE may contribute to prediction for cardiovascular disease. For example, the 374T3A variant has been shown to be protective against the development of cardiovascular disease (T/A or A/A individuals) in both diabetic and nondiabetic individuals.…”