Polymorphism Study of BMPR-1B and BMP-15 Genes in Berari Goats

Sharma, Laxmi Kant; Kuralkar, S. V.; Ali, S. Sajid; Bankar, P.S.; Kuralkar, Prajakta

doi:10.5958/0973-9718.2016.00062.3

Cited by 2 publications

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“…Similar to this study, the FecB mutation has been previously found in several goat breeds, including Black Bengal (Polley et al, 2009), Markhoz (Shokrollahi and Morammazi, 2018), Beetal and Teddy goats (Islam et al, 2019). In contrast, it has not been found in some other goat breeds, including the Rayini goats of Iran (Gazooei et al, 2013), the prolific Raighar (Palai et al, 2013), the Indian Berari and Surti goat (Sharma et al, 2016;Dangar et al, 2019), and some Egypt sheep breeds (Abulyazid et al, 2011;El-Seedy et al, 2017;Saleh et al, 2020). The possible reasons for the differences between the results obtained from different breeds may be due to: (1) the accumulation of certain genotypes and alleles as a result of intensive selection, (2) the possibility of inbreeding, and (3) the possibility of previous genes introgression as a breeding strategy.…”

Section: Polymorphism Of Bmpr-1b Gene In Kacang and Boerka Goatsupporting

confidence: 87%

Identification of FecXG and FecB Mutations and its Association with Litter Size in Kacang and Boerka Goat

Maskur¹,

Muhsinin²,

Depamede³

2022

AAVS

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The Kacang goat is one of Indonesia's prolific native goat breeds, while the Boerka goat is a crossbreed between Kacang and Boer goats. It is widely known that the ovulation rate and litter size in sheep breeds are significantly impacted by the BMP15 (FecX G ) and BMPR-1B (FecB) gene alterations. Based on this knowledge, the study's objective was to determine the presence of BMP15 and BMPR-1B gene polymorphisms and how they affected the prolific traits of Kacang and Boerka goats. This study indicates that the FecX G and FecB mutations were associated with litter size in Kacang and Boerka goat breeds. The FecX G has two genotypes in both Kacang and Boerka goats, namely homozygote wild type ++ and heterozygote mutant carrier G+ with a litter size of 1.

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Section: Polymorphism Of Bmpr-1b Gene In Kacang and Boerka Goatsupporting

confidence: 87%

Identification of FecXG and FecB Mutations and its Association with Litter Size in Kacang and Boerka Goat

Maskur¹,

Muhsinin²,

Depamede³

2022

AAVS

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“…The BMPR-1B gene was the first major gene associated with reproductively in sheep [7,8]. There are 22 single nucleotide polymorphisms (SNPs) reported for BMPR-1B (http://www.ncbi.nlm.nih.gov/gene/443454), but only 4 SNPs change the amino acid sequence in the gene (G192A, A746G, G922T, and T1043C) [9,10]. A major research on the non-synonymous SNP of A746G found that the damage to the BMP system during follicle development led to increase average ovulation in Booroola Merino sheep, Cambridge sheep and Small Tail Han sheep [11–13].…”

Section: Introductionmentioning

confidence: 99%

Association of polymorphisms in bone morphogenetic protein receptor-1B gene exon-9 with litter size in Dorset, Mongolian, and Small Tail Han ewes

Jia

Chen

Gui

et al. 2019

Asian-Australas J Anim Sci

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Objective The present study was to investigate the association of polymorphisms in exon-9 of the bone morphogenetic protein receptor-1B ( BMPR-1B ) gene (C864T) with litter size in 240 Dorset, 232 Mongolian, and 124 Small Tail Han ewes. Methods Blood samples were collected from 596 ewes and genomic DNA was extracted using the phenol: chloroform extraction method. The 304-bp amplified polymerase chain reaction product was analyzed for polymorphism by single-strand conformation polymorphism method. The genotypic frequency and allele frequency of BMPR-1B gene exon-9 were computed after sequence alignment. The χ 2 independence test was used to analyze the association of genotypic frequency and litter size traits with in each ewe breed, where the phenotype was directly treated as category. Results The results indicated two different banding patterns AA and AB for this fragment, with the most frequent genotype and allele of AA and A. Calculated Chi-square test for BMPR-1B gene exon-9 was found to be more than that of p value at the 5% level of significance, indicating that the population under study was in Hardy-Weinberg equilibrium for all ewes. The χ 2 independence test analyses indicated litter size differences between genotypes was not the same for each breed. The 304-bp nucleotide sequence was subjected to BLAST analysis, and the C864T mutation significantly affected litter size in singletons, twins and multiples. The heterozygosity in exon-9 of BMPR-1B gene could increase litter size for all the studied ewes. Conclusion Consequently, it appears that the polymorphism BMPR-1B gene exon-9 detected in this study may have potential use in marker assisted selection for litter size in Dorset, Mongolian, and Small Tail Han ewes.

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Polymorphism Study of BMPR-1B and BMP-15 Genes in Berari Goats

Cited by 2 publications

References 0 publications

Identification of FecXG and FecB Mutations and its Association with Litter Size in Kacang and Boerka Goat

Identification of FecXG and FecB Mutations and its Association with Litter Size in Kacang and Boerka Goat

Association of polymorphisms in bone morphogenetic protein receptor-1B gene exon-9 with litter size in Dorset, Mongolian, and Small Tail Han ewes

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