Polymorphism of red cell enzymes in Alaskan ethnic groups

Abstract

1. Gene frequencies of esterase D, glyoxalase I and uridine monophosphate kinase in Alaskan populations were determined. 2. Improved methods for demonstrating phenotypes of glyoxalase I and uridine monophosphate kinase are presented. 3. Rare variants of adenylate kinase (AK1) and diaphorase (DIA) were found. One of the AK1 variants is new. 4. Gene frequencies were notably diverse within major ethnic groups. This variability was consistent with a population structure composed of small groups that were relatively isolated from one another.

Population Genetic Studies on Nine Aboriginal Ethnic Groups of Taiwan. I. Red Cell Enzyme Systems.

“…In addition to the common allele GOT*1, two different electrophoretically identifiable alleles were reported (Chen and Giblett, 1971;Ishimoto and Kuwata, 1974;Teng and others, 1978;Scott and Wright, 1978). However, in this study, distribution of GOT in all the individuals of the nine Taiwan ethnic groups showed the identical type, GOT 1.…”

Genetic Polymorphisms in Southwest Alaskan Eskimos

“…The gene frequencies at the phenotypic loci that we observed do not differ signif icantly from other reports in the Yupikspeaking Eskimo for ESD [6,7] and ACP, AK, HP, GLO, PGM, and GPT [4. 5, 7], and the blood groups ABO and MN [38].…”

“…In the Arctic Investigations Laboratory, stan dard methods were utilized for characterizing the red cell enzymes ESD [26] and GPT [27], UMPK [6]. and the erythrocyte antigens ABO.…”

“…Approxi mately 5,000 live in Bethel, the largest town in this area, on the Kuskokwim Riv- er, and the remainder are scattered in 50 villages, each with less than 300 individuals (f'g-I)-Several investigators have reviewed the genetic studies of peoples of the circum polar region and Eskimo affinities with Asian stock [1][2][3]. These and previous ge netic analyses of southwest Alaskan Eski mo genetic data [4][5][6][7] show that there is genetic diversity, but there is no marked departure of the Yupik-speaking Eskimo gene frequencies from other circumpolar Eskimo populations.…”

Protein genetic studies among the Tupi-Mondé Indians of the Brazilian Amazonia

“…The occurrence of AK*4 is more difficult to interpret. A variant with about the same electrophoretic mobility was observed in very low prevalences in the United Kingdom and Africa (Rapley et al, 1967;Hiernaux, 1976), but also in North American Indians (Athabaskans) and Eskimos (Scott and Wright, 1978). The finding of one Rh negative among the Surui (see footnote, Table 1) also could be due to admixture.…”