Population Genetic Studies on Nine Aboriginal Ethnic Groups of Taiwan. I. Red Cell Enzyme Systems.

Jin, Feng; Saitou, Naruya; Ishida, Takafum; Sun, Cheih-Shan; Pan, I-Hung; Omoto, Keiichi; Hora, Satoshi

doi:10.1537/ase.107.229

Cited by 6 publications

(6 citation statements)

References 13 publications

(9 reference statements)

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“…The population of Taiwan is largely comprised of early immigrants from mainland China from the 17th century and recent immigrants after World War II, whereas the aboriginal population accounts for around 1.5% of the total population (Jin et al 1999;Lin et al 2000). The population of Taiwan is largely comprised of early immigrants from mainland China from the 17th century and recent immigrants after World War II, whereas the aboriginal population accounts for around 1.5% of the total population (Jin et al 1999;Lin et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…The population of Taiwan is largely comprised of early immigrants from mainland China from the 17th century and recent immigrants after World War II, whereas the aboriginal population accounts for around 1.5% of the total population (Jin et al 1999;Lin et al 2000). Although there are several hypotheses regarding the origin of these aboriginal people, none has gained general acceptance (Melton et al 1998;Jin et al 1999). As shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan: implications for the population history of aboriginal Taiwanese

Tajima

Sun²,

Pan

et al. 2003

Hum Genet

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Mitochondrial DNA (mtDNA) polymorphisms in the D-loop region and the intergenic COII/tRNA Lys 9-bp deletion were examined in 180 individuals from all nine aboriginal Taiwanese groups: Atayal, Saisiat, Bunun, Tsou, Rukai, Paiwan, Ami, Puyuma, and Yami. A comparison of 563-bp sequences showed that there were 61 different sequence types, of which 42 types were specific to respective aboriginal groups. D-loop sequence variation and phylogenetic analysis enabled the 180 aboriginal lineages to be classified into eight monophyletic clusters (designated C1-C8). Phylogeographic analysis revealed that two (C2 and C4) of the eight clusters were new characteristic clusters of aboriginal Taiwanese and accounted for 8.3% and 13.9% of the aboriginal lineages, respectively. From the estimated coalescent times for the two unique clusters, the mtDNA lineages leading to such clusters were inferred to have been introduced into Taiwan approximately 11,000-26,000 years ago, suggesting ancient immigrations of the two mtDNA lineages. Genetic distances, based on net nucleotide diversities between populations, revealed three distinct clusters that were comprised of northern mountain (Atayal and Saisiat), southern mountain (Rukai and Paiwan), and middle mountain/east coast (Bunun, Tsou, Ami, Puyuma, and Yami) groups, respectively. Furthermore, phylogenetic analysis of 16 human populations (including six other Asian populations and one African population) confirmed that the three clusters for aboriginal Taiwanese had remained largely intact. Each of the clusters (north, south, and middle-east coast) was characterized by a high frequency of a particular lineage (C4, C2, and 9-bp deletion, respectively). This may result from random genetic drift among the aboriginal groups after a single introduction of all the mtDNA lineages into Taiwan, but another plausible explanation is that at least three genetically distinct ancestral populations have contributed to the maternal gene pool of aboriginal Taiwanese.

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Section: Introductionmentioning

confidence: 99%

“…The population of Taiwan is largely comprised of early immigrants from mainland China from the 17th century and recent immigrants after World War II, whereas the aboriginal population accounts for around 1.5% of the total population (Jin et al 1999;Lin et al 2000). Although there are several hypotheses regarding the origin of these aboriginal people, none has gained general acceptance (Melton et al 1998;Jin et al 1999). As shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan: implications for the population history of aboriginal Taiwanese

Tajima

Sun²,

Pan

et al. 2003

Hum Genet

Self Cite

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“…There are many theories surrounding the peopling of these islands and no single one enjoys full approval (Jin et al 1999). Both archeological and linguistic data indicate that Austronesian-speaking populations were responsible for this expansion (Diamond 1988).…”

Section: Introductionmentioning

confidence: 99%

“…There are nine tribal groups that currently constitute the aboriginal population of Formosa: Ami, Atayal, Bunun, Paiwan, Puyama, Rukai, Saisiya, Tsou, and Yami (Jin et al 1999). They comprise approximately 1.5% of Taiwan's total population which currently numbers 21 million (Chu 1997;Jin et al 1999).…”

Section: Introductionmentioning

confidence: 99%

“…They comprise approximately 1.5% of Taiwan's total population which currently numbers 21 million (Chu 1997;Jin et al 1999). The remainder of the population consists mainly of the Han Chinese who have been instrumental in the displacement and redistribution of the native groups since ancient times to the rugged inland mountains and the eastern coastline (Kao 1958;Chai 1967).…”

Section: Introductionmentioning

confidence: 99%

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Genetic characterization of four Austronesian-speaking populations

et al. 2005

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Ascertaining the genetic relationships between Austronesian populations is paramount to understanding their dispersal throughout the islands of the Pacific and Indian Oceans. The start of the Austronesian expansion has been dated to approximately 6,000 years ago, and from linguistic and archeological evidence, the origin of this dispersal may have been the island of Formosa. Consequently, the Taiwanese aboriginal populations and their phylogenetic relationship to the Austronesian-speaking groups from Madagascar at the occidental fringes of the expansion are of great interest. In this study, allelic frequencies from six polymorphic point mutation loci were assessed in the Austronesianspeaking populations of Madagascar, the Atayal aborigines of Formosa, and the general populations of Bali and Java. These allelic frequencies were compared and analyzed with the corresponding values from eight other worldwide populations from geographically targeted regions. The group from Madagascar is genetically distinct from their east-African neighbor from Zimbabwe. Our data also indicates that the Ami and the Atayal aborigines in the island of Taiwan, which occupy adjacent territories, differ sharply genetically. Genetic differences were also found between the populations of Bali and Java, belying their geographical proximity. Our results indicate that the east-African population from Madagascar phylogenetically segregates intermediate between mainland east-African and east-Asian groups, corroborating linguistic data indicating the Austronesian influence on this population.

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HLA phenotypes and outcomes of hepatitis B virus infection in Taiwan

Wang

Lee

et al. 2003

Journal of Medical Virology

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The relationship of HLA phenotype and outcome of hepatitis B virus (HBV) infection was studied in two ethnic groups of Taiwan: Han Chinese and Taiwanese Aborigines. In Han Chinese, the study groups consisted of 98 persons who tested both hepatitis B surface antigen (HBsAg) and anti-HBs negative (Uninfected Group), 324 persons who tested HBsAg negative and both anti-HBs and anti-HBc positive (Recovered Group), and 98 patients who tested HBsAg positive for at least 6 months (Chronically Infected Group). In Taiwanese Aborigines, the study groups consisted of 34 persons in Uninfected Group, 229 persons in the Recovered Group, and 138 patients in the Chronically Infected Group. All subjects were tested for HLA (A, B, DRB1) phenotypes by sequence-specific oligonucleotide probe hybridization (SSOPH). HLA-DR*0406 was significantly more frequent in the Recovered Group, compared with the Chronically Infected Group (P < 0.001) in Han Chinese. There was a significant excess of HLA-B*4001 (P = 0.045) in the Recovered Group, compared with the Chronically Infected Group in Taiwanese Aborigines. The observation that different HLA phenotypes associated with recovery from HBV infection in different racial groups implies that various HLA molecules could present different HBV epitopes to induce effective immune responses.

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Population Genetic Studies on Nine Aboriginal Ethnic Groups of Taiwan. I. Red Cell Enzyme Systems.

Cited by 6 publications

References 13 publications

Mitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan: implications for the population history of aboriginal Taiwanese

Mitochondrial DNA polymorphisms in nine aboriginal groups of Taiwan: implications for the population history of aboriginal Taiwanese

Genetic characterization of four Austronesian-speaking populations

HLA phenotypes and outcomes of hepatitis B virus infection in Taiwan

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