Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity

Parfenov, Michael; Nikolaeva, Tatyana Y.; Судомоина, М. А.; Fedorova, Sardana A.; Guekht, Alla; Gusev, Eugene; Фаворова, О. О.

doi:10.1016/j.jns.2007.01.068

Cited by 20 publications

(19 citation statements)

References 45 publications

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“…A study in China showed a 2.1-fold significantly increased risk of ischemic stroke in Apo ε4 carriers [53] . These results were replicated in a Tunisia study [51,54] , where Apo ε4 was found to be higher in the stroke patients (0.370 vs 0.181; P<0.001). Furthermore, there have been reports on the role of the ε4 allele as a prognostic genetic marker for the atherothrombotic subtype, lacunar infarcts [55] and carotid plaques [56] .…”

Section: Lipid Metabolismmentioning

confidence: 55%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

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Section: Lipid Metabolismmentioning

confidence: 55%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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“…биологии, медицинской ге-нетики и экологии; 305041 Курск, ул. К. Маркса, 3; тел./факс: +7(471)258-8147; е-mail: olga.bushueva@inbox.ru ИИ, однако во многих случаях результаты исследований оказались противоречивыми [1][2][3][4][5][6][7][8][9]. Известно, что основ-ной причиной ИИ служит атеросклероз мозговых сосу-дов, в развитии которого ведущую роль играют наруше-ния липидного обмена.…”

Section: терапевтический архив 8 2015unclassified

“…Данные литературы относительно вклада полимор-физма Taq1B гена CETP и полиморфизма HindIII гена LPL в формирование риска развития ИИ противоречивы и немногочисленны [3][4][5][6][7]16]. В России проведено лишь два исследования по изучению ассоциации полиморфиз-ма HindIII гена LPL с риском развития ИИ (в якутской и русской популяциях) [6][7], тогда как исследований по-лиморфизма Taq1B гена CETP не проводилось.…”

Section: терапевтический архив 8 2015unclassified

“…В России проведено лишь два исследования по изучению ассоциации полиморфиз-ма HindIII гена LPL с риском развития ИИ (в якутской и русской популяциях) [6][7], тогда как исследований по-лиморфизма Taq1B гена CETP не проводилось. Различия в результатах генетических исследований генов CETP и LPL при сосудисто-мозговых заболеваниях могут быть связаны с генетической гетерогенностью изученных по-пуляций.…”

Section: терапевтический архив 8 2015unclassified

“…Полученные нами результаты согласуются с данными другого проведенного в России исследования, выпол-ненного в популяции якутов [6], в котором обнаружена ассоциация вариантного аллеля G с повышенным ри-ском развития ИИ у женщин. Однако согласно получен-ным нами результатам полиморфизм HindIII (T+495G) гена LPL связан с повышенным риском развития АИ у мужчин.…”

Section: терапевтический архив 8 2015unclassified

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Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

Бушуева¹,

Ta²,

Tv³

et al. 2015

Ter. arkh.

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Apolipoprotein E gene polymorphism in psoriasis

et al. 2009

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Polymorphism in the apolipoprotein E gene has been associated with several neurological, cardiological and ophthalmological diseases. Apolipoprotein E is involved in psoriasis by modifying mitogen-activated T lymphocyte proliferation and by assuring protection against some infections. We evaluated the apolipoprotein E gene polymorphism in patients suffering from psoriasis (compared to matched controls) in Thrace, Northern Greece. One hundred and forty patients suffering from psoriasis vulgaris and 155 matched controls were included in this study and genotyped by semi-nested polymerase chain reaction RFLPs; the results were evaluated by conditional logistic regression. In psoriasis vulgaris patients, the e2 allele showed higher frequency (6.1%, P = 0.021) versus matched controls (2.3%). The above data were ascertained particularly enforced in psoriasis vulgaris male patients (P = 0.031) as well as in late onset psoriasis vulgaris (P = 0.029). Implication of apolipoprotein E in the pathogenesis of psoriasis has been indicated. Allele e2 is more frequent in psoriatic patients and its presence is more evident in late onset psoriasis vulgaris.

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Polymorphism of apolipoprotein E (APOE) and lipoprotein lipase (LPL) genes and ischaemic stroke in individuals of Yakut ethnicity

Cited by 20 publications

References 45 publications

Genetics of stroke

Genetics of stroke

Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

Apolipoprotein E gene polymorphism in psoriasis

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