Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

Бушуева, О. Ю.; Ta, Stetskaya; Tv, Korogodina; Vp, Ivanov; Polonikov, Alexey

doi:10.17116/terarkh201587886-91

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Обращает на себя внимание, что в данном исследовании удалось подтвердить отмеченную Usoltsev D, et al (2023) [7] [7], найденные в выборках ЭССЕ-Вологда и ЭССЕ-Иваново для ХС ЛВП, находятся в гене CETP, и прошли репликацию. Известно, что ген CETP регулирует содержание ХС ЛВП в крови [23]. В частности, была подтверждена ассоциация ВНП rs708272 с уровнем ХС ЛВП.…”

Section: Discussionunclassified

Search and replication of associations of genome variants with lipid levels in a Russian sample

Zaichenoka,

Ershova,

Kiseleva

et al. 2024

Cardiovasc Ther Prev

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Aim. To search associations for lipid profile parameters (lowand highdensity lipoprotein cholesterol levels, triglycerides and total cholesterol) in population samples from two Russian regions and make a replication analysis of a previously published genome-wide association study (GWA study, GWAS) for residents of three other Russian regions.Material and methods. The study included representative samples from the Vologda (n=689) and Ivanovo (n=1675) regions collected for the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation (ESSE-RF) study. We assessed lipid profile parameters and performed a targeted sequencing. A linear regression model adjusted for sex, age, and statin use was used to assess the associations of genomic variants with lipid profiles. The work replicated the results of a study by Usoltsev D, et al., 2023, carried out on population samples of individuals from St.Petersburg, Orenburg and Samara regions.Results. We identified variants for which associations with lipid parameters had previously been identified in a Russian sample. The proportion of replicated variants was 89% and 92% for the samples from the Vologda and Ivanovo regions, respectively. The directions of effects of all replicated variants in the previously published study (samples from the Orenburg and Samara regions and St. Petersburg) and in both studied samples (samples from the Ivanovo and Vologda regions) coincide.Conclusion. The results of the search for associations with lipid parameters in different Russian samples are consistent with each other.

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Section: Discussionunclassified

Search and replication of associations of genome variants with lipid levels in a Russian sample

Zaichenoka,

Ershova,

Kiseleva

et al. 2024

Cardiovasc Ther Prev

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“…Researchers believe that rs1801282 ( Figure 6) causes increased sensitivity to insulin, total cholesterol, HDL (high-density lipoprotein) and increased glucose utilization, which serves as a protective mechanism against diabetes mellitus and obesity [22]. The CETP gene is one of the key lipid metabolism genes, as it encodes the carrier protein of cholesterol esters, i.e., the gene translates "good" HDL cholesterol into "bad" LDL (low density lipoprotein) [23]. Rs5882 ( Figure 7) is a cause of change in the primary structure of the protein, resulting in a decrease in HDL and increased LDL, i.e., in atherosclerosis and ischemic diseases of the heart and vessels [24].…”

Section: Genes Responsible For the Digestion And Absorption Of Carbohmentioning

confidence: 99%

Genes and Eating Preferences, Their Roles in Personalized Nutrition

Vesnina

Prosekov

Kozlova

et al. 2020

Genes

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At present, personalized diets, which take into account consumer genetic characteristics, are growing popular. Nutrigenetics studies the effect of gene variations on metabolism and nutrigenomics, which branches off further and investigates how nutrients and food compounds affect genes. This work deals with the mutations affecting the assimilation of metabolites, contributing to nutrigenetic studies. We searched for the genes responsible for eating preferences which allow for the tailoring of personalized diets. Presently, genetic nutrition is growing in demand, as it contributes to the prevention and/or rehabilitation of non-communicable diseases, both monogenic and polygenic. In this work, we showed single-nucleotide polymorphisms in genes—missense mutations that change the functions of coded proteins, resulting in a particular eating preferences or a disease. We studied the genes influencing food preferences—particularly those responsible for fats and carbohydrates absorption, food intolerance, metabolism of vitamins, taste sensations, oxidation of xenobiotics, eating preferences and food addiction. As a result, 34 genes were identified that affect eating preferences. Significant shortcomings were found in the methods/programs for developing personalized diets that are used today, and the weaknesses were revealed in the development of nutrigenetics (inconsistency of data on SNP genes, ignoring population genetics data, difficult information to understand consumer, etc.). Taking into account all the shortcomings, an approximate model was proposed in the review for selecting an appropriate personalized diet. In the future, it is planned to develop the proposed model for the compilation of individual diets.

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“…Материалом для исследования послужила выборка неродственных, русских индивидов, проживающих в Курской области, общей численностью 852 человека. В исследование вошли 378 пациентов с МИ (217 мужчин, 161 женщина), которые находились на стационарном лечении в Региональном сосудистом центре Курской областной клинической больницы и в неврологическом отделении Курской Городской клинической больницы скорой медицинской помощи в период 2011-2017 гг [5][6][7]. Группу сравнения составили 474 практически здоровых добровольцев (263 мужчины, 211 женщин) без хронических заболеваний в анамнезе и имеющих нормальный уровень артериального давления.…”

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Роль Генов Антиоксидантной Системы В Формировании Предрасположенности К Развитию Цереброваскулярных Заболеваний: Анализ Ассоциаций Однонуклеотидных Полиморфизмов И Метилирования ДНК

Бушуева¹,

Барышева²,

Марков³

et al. 2021

Modern Issues of Biochemistry, Genetics and Biotechnology

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Investigation of the association between the HindIII polymorphism of the LPL gene and the Taq1b polymorphism of the CETP gene with the risk of atherothrombotic stroke in the dwellers of Central Russia

Cited by 5 publications

References 23 publications

Search and replication of associations of genome variants with lipid levels in a Russian sample

Search and replication of associations of genome variants with lipid levels in a Russian sample

Genes and Eating Preferences, Their Roles in Personalized Nutrition

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