Apolipoprotein E gene polymorphism in psoriasis

Karpouzis, Anthony; Caridha, Rozina; Tripsianis, Gregory; Michailidis, Charalambos; Martinis, George; Veletza, Stavroula

doi:10.1007/s00403-009-0968-0

Cited by 16 publications

(18 citation statements)

References 48 publications

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“…Zervou et al (2009) found a weak association between the T allele in rs7574865 ( STAT4 ) and predisposition to psoriasis (Table 1) [72]. APOE may play a role in psoriasis by modifying the proliferation of mitogen-activated T lymphocytes and ensuring protection against some infections (Figure 1) [73]. Other authors have reported the APOE- ε 4 allele to be a risk factor for the development of severe form of psoriasis [74].…”

Section: Genetics Of Psoriasismentioning

confidence: 99%

Genetics of Psoriasis and Pharmacogenetics of Biological Drugs

Prieto-Pérez

Cabaleiro

Daudén

et al. 2013

Autoimmune Diseases

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Psoriasis is a chronic inflammatory disease of the skin. The causes of psoriasis are unknown, although family and twin studies have shown genetic factors to play a key role in its development. The many genes associated with psoriasis and the immune response include TNFα, IL23, and IL12. Advances in knowledge of the pathogenesis of psoriasis have enabled the development of new drugs that target cytokines (e.g., etanercept, adalimumab, and infliximab, which target TNFα, and ustekinumab, which targets the p40 subunit of IL23 and IL12). These drugs have improved the safety and efficacy of treatment in comparison with previous therapies. However, not all patients respond equally to treatment, possibly owing to interindividual genetic variability. In this review, we describe the genes associated with psoriasis and the immune response, the biological drugs used to treat chronic severe plaque psoriasis, new drugs in phase II and III trials, and current knowledge on the implications of pharmacogenomics in predicting response to these treatments.

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Section: Genetics Of Psoriasismentioning

confidence: 99%

Genetics of Psoriasis and Pharmacogenetics of Biological Drugs

Prieto-Pérez

Cabaleiro

Daudén

et al. 2013

Autoimmune Diseases

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“…They have a different molecular structure, amino acid composition, and antiatherosclerotic properties. In psoriatic patients, different results concerning apolipoproteins apoA1, apoB, and apoE were presented [16, 41, 66, 67]. Apolipoprotein A1 has been immunocytochemically detected at the psoriatic skin dermoepidermal junction, vascular walls, and the perivascular region of papillary dermis.…”

Section: Apolipoproteinsmentioning

confidence: 99%

“…Apolipoprotein E (ApoE) is a glycoprotein involved in the regulation of triglycerides and low-density lipoprotein (LDL) levels [67]. ApoE can modulate mitogen-activated T-lymphocyte proliferation in vitro and provides protection against some infections [82, 83].…”

Section: Apolipoproteinsmentioning

confidence: 99%

“…ApoE can modulate mitogen-activated T-lymphocyte proliferation in vitro and provides protection against some infections [82, 83]. The role of the apoE gene in psoriasis was suggested, because in psoriatic skin there is the downregulation of ApoE expression and the normalization of ApoE levels precedes clinical improvement [67]. Furthermore, in a Japanese population the epsilon 2 allele was found to be significantly more frequent in psoriatic patients than in controls, suggesting that there may be a relationship between these particular alleles and development of psoriasis [84].…”

Section: Apolipoproteinsmentioning

confidence: 99%

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Lipid Disturbances in Psoriasis: An Update

Pietrzak

Michalak-Stoma

Chodorowska

et al. 2010

Mediators of Inflammation

122

109

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Psoriasis is a common disease with the population prevalence ranging from 2% to 3%. Its prevalence in the population is affected by genetic, environmental, viral, infectious, immunological, biochemical, endocrinological, and psychological factors, as well as alcohol and drug abuse. In the recent years, psoriasis has been recognised as a systemic disease associated with numerous multiorgan abnormalities and complications. Dyslipidemia is one of comorbidities in psoriatic patients. Lipid metabolism studies in psoriasis have been started at the beginning of the 20th century and are concentrated on skin surface lipids, stratum corneum lipids and epidermal phospholipids, serum lipids, dermal low-density lipoproteins in the psoriatic skin, lipid metabolism, oxidative stress and correlations between inflammatory parameters, lipid parameters and clinical symptoms of the disease. On the basis of the literature data, psoriasis can be described as an immunometabolic disease.

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“…ApoE is mainly produced in the liver, but other organs and tissues such as the brain, spleen, kidneys, gonads, adrenals, and macrophages also produce this protein (Mahley, 1988). Accumulating evidence reveals that the polymorphism of the apoE gene is genetically associated with many diseases, including essential hypertension (EH), coronary artery disease, polycystic ovary syndrome, Alzheimer's disease, psoriasis, vascular dementia, gallbladder stone disease, and cerebrovascular disorders (Karpouzis et al, 2009;Chaudhary et al, 2012;Liu et al, 2012a;Xue et al, 2012;Yin et al, 2012;Zhou et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

Yang¹,

Xu²,

Liu³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. In the present study, the correlation of polymorphisms of the apolipoprotein E (apoE) gene with the susceptibility of essential hypertension (EH) was investigated. Single nucleotide polymorphisms of the apoE gene at the -491 A>T, +969 C>G, and +2836 G>A sites were determined in 221 non-EH individuals and 109 subjects with EH of Chinese Hui ethnicity using polymerase chain reaction-restriction fragment length polymorphism analysis. The results showed that neither the genotypic frequency nor the allelic frequency at the -491 A>T and +969 C>G sites exhibited a statistically significant difference between these two groups (P > 0.05). However, a significant difference was observed in genotypic frequency and allelic frequency at the +2836 G>A site between EH patients and non-EH individuals (P < 0.01). In addition, a significantly higher frequency of the A allele at the +2836 G>A site was also detected in EH patients (83%) compared with controls (47.5%) (P < 0.01; OR = 4.82, 95%CI = 3.25-7.17); Polymorphisms of the apoE gene in the Chinese Hui population in contrast, the frequency of the G allele at the +2836 G>A site was significantly lower (17%) in the patient group in comparison with the non-EH cohorts (52.5%) (P < 0.01; OR = 0.21, 95%CI = 0.14 -0.31). These results suggest that the polymorphism at the +2836 G>A site in the apoE gene is strongly correlated with the susceptibility to EH in the Chinese Hui ethnic population.

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Apolipoprotein E gene polymorphism in psoriasis

Cited by 16 publications

References 48 publications

Genetics of Psoriasis and Pharmacogenetics of Biological Drugs

Genetics of Psoriasis and Pharmacogenetics of Biological Drugs

Lipid Disturbances in Psoriasis: An Update

Polymorphisms of +2836 G>A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population

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