Polymers for pharmaceutical applications

Sobczak, Marcin; Olędzka, Ewa; Kołodziejski, Wacław; Kuzmicz, Rafal

doi:10.14314/polimery.2007.411

Cited by 38 publications

(27 citation statements)

References 3 publications

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“…Aliphatic polyesters are widely used for medical applications, such as drug‐delivery systems or resorbable implants 1–9. Poly(ϵ‐caprolactone) (PCL), polyglycolide, polylactide (PLA), and their copolymers are degraded by the hydrolysis of their ester linkages in physiological conditions, such as in the human body.…”

Section: Introductionmentioning

confidence: 99%

Enzyme‐catalyzed ring‐opening polymerization of cyclic esters in the presence of poly(ethylene glycol)

Sobczak

2012

J of Applied Polymer Sci

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Low-molecular-weight polyesters were obtained by the ring-opening homopolymerization and copolymerization reaction of e-caprolactone, rac-or L-lactide, and glycolide in the presence of poly(ethylene glycol) with an enzyme catalyst, a lipase from Candida antarctica, Pseudomonas cepacia, or Pseudomonas fluorescens. The influence of several parameters, including time, temperature, and enzyme and monomer concentration, on the polymerization rate was studied. The resulting polymers were characterized by 1 H-NMR or 13 C-NMR, Fourier transform infrared spectroscopy, matrix-assisted laser desorption/ionization-time of flight mass spectroscopy, and gel permeation chromatography.

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Section: Introductionmentioning

confidence: 99%

Enzyme‐catalyzed ring‐opening polymerization of cyclic esters in the presence of poly(ethylene glycol)

Sobczak

2012

J of Applied Polymer Sci

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“…However, the fading of bands, typical for characteristic groups, found in particular drugs might indicate the formation of bonds between the polymer and substance. The bands are not visible in the spectrum of the polymer -a therapeutic substance, which might be associated with the fact that the substance spectrum is overlaid by an intensive polymer spectrum [20].…”

Section: Ftir Resultsmentioning

confidence: 99%

Starch Film as a Carrier of a Model Drug Substance from the Group of Non-Steroidal Anti-Inflammatory Drugs

Wawro

Bodek

2018

Fibres and Textiles in Eastern Europe

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The article describes the production of starch film as a carrier of a model drug substance from the group of non-steroidal anti-inflammatory drugs (NSAIDs). An analgesic/anti- inflammatory drug was put into aqueous starch solution, and next a film was formed. The following solid drug substances were included in the tests: acetylsalicylic acid, salicylic acid, ibuprofen lysine salt, naproxen in the form of acid, and sodium salt. Solutions were obtained from ibuprofen lysine salt and naproxen sodium, whereas the other drugs enabled to obtain aqueous suspensions. Such a drug substance was mixed with aqueous starch solution to obtain a film. Forming a film under laboratory conditions involved spreading aqueous starch solution containing a drug on a flat heated surface and evaporating water. The films obtained were transparent. They were then dried for a period of 24 hours at a temperature of 20 °C and 50% relative air humidity. Next their mechanical properties were studied. Starch films which contained therapeutic substances were characterised by Fourier transform infrared spectroscopy (FTIR). There were slight differences between the spectra of films containing a drug substance and those of films containing both starch and a drug substance, which implies weak intermolecular reactions. Scanning electron microscope (SEM) images of cross-sections of the starch films with a drug substance were taken, which indicated their uniform morphological structure. The release rate of the drug from each film to an acetate buffer pH 4.5 (acetylsalicylic acid and salicylic acid) or phosphate buffer pH 7.38 (ibuprofen lysine salt and naproxen) was determined in vitro with the paddle method. This procedure took up to 90 min. Acetylsalicylic acid and salicylic acid were almost completely released from the starch film as early as in the first minutes of the procedure, with a maximum value of around 90%. The release of ibuprofen lysine salt and naproxen in the form of acid from the starch film was partial, about 40%. The release of naproxen sodium from the starch film was time-proportional, and there was a tendency towards further release.

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“…The polymer materials used for manufacturing medical devices have been the subject of numerous reviews [1][2][3]. These reviews emphasise the importance of polymer materials for health service.…”

Section: Polymers For Manufacturing Medical Devices and Materialsmentioning

confidence: 99%

Polymers in medicine direction of development

et al. 2019

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The paper constitutes a brief and subjective review of polymeric materials in the contemporary health service. The range of applications of polymeric materials is discussed, special att ention being paid to such materials for the development of carriers of pharmaceutically active species, stents and vascular prostheses, amongst them to the application of "smart" materials for these purposes, layers and scaff olds for the growth of organs and tissues, antifouling layers. The authors try to turn the att ention of the reader to the research and intellectual eff orts necessary for the development of polymeric materials for the medicine, and conclude about the growing importance of such studies.

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Polymers for pharmaceutical applications

Cited by 38 publications

References 3 publications

Enzyme‐catalyzed ring‐opening polymerization of cyclic esters in the presence of poly(ethylene glycol)

Enzyme‐catalyzed ring‐opening polymerization of cyclic esters in the presence of poly(ethylene glycol)

Starch Film as a Carrier of a Model Drug Substance from the Group of Non-Steroidal Anti-Inflammatory Drugs

Polymers in medicine direction of development

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