Polymerizable Anionic Gemini Surfactants: Physicochemical Properties in Aqueous Solution and Polymerization Behavior

Sakai, Kenichi; Wada, Mayuko; Matsuda, Wataru; Tsuchiya, Koji; Takamatsu, Yuichiro; Tsubone, Kazuyuki; Endo, Takeshi; Torigoe, Kanjiro; Sakai, Hideki; Abe, Masahiko

doi:10.5650/jos.58.403

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…The pyrene method was used to measure the critical micelle concentration (CMC) of P188TT. 27,30 Briefly, pyrene solution (6 Â 10 À6 mol/ L, 10 μL) and P188TT NPs suspension (10 mL) were added to volumetric flasks and balanced for 24 h. The concentrations of P188TT were varied from 1 Â 10 À6 to 0.05 mg/mL. F5103PC fluorophotometer (Shimadzu, Japan) was used to measure the fluorescence intensities (λ ex = 384 nm, λ em = 373 nm).…”

Section: Critical Micelle Concentrationmentioning

confidence: 99%

Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation

Hou

et al. 2023

Polymers for Advanced Techs

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Glioma is the most common primary cancer of central nervous system due to its rapid proliferation and high lethality. In this study, a novel poloxamer188‐based drug delivery system, poloxamer188‐poly(1,4,8‐trioxaspiro[4.6]undecan‐9‐one)‐poly(1,3‐dioxan‐2‐one) nanoparticles (P188TT NPs) were developed. The 1H NMR, Raman and FITC spectra demonstrated that P188TT copolymer was successfully synthesized. The critical micelle concentration (CMC) measurement showed that P188TT NPs had a low CMC. The characterization and bio‐safety assessment verified that P188TT NPs had the appropriate size, zeta potential, good stability, and ideal bio‐safety. In addition, the curcumin‐loaded P188TT NPs (Cur/P188TT NPs) were fabricated and then analyzed by differential scanning calorimeter (DSC) and thermalgravimetric analysis (TGA). The in vitro release study displayed that the release rate of Cur from Cur/P188TT NPs in pH 6.8 was appreciably faster than that in pH 7.4. The tissue distribution study showed that these NPs had good brain‐targeting efficiency. The cellular uptake assay suggested that P188TT NPs could promote the uptake of Cur in glioma cells. The MTT tests indicated that P188TT NPs could increase the anti‐tumor activity of encapsulated drugs. Therefore, P188TT NPs showed potential as a brain targeting nano‐carrier for glioma therapy, which required further validation in glioma models in vivo.

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Section: Critical Micelle Concentrationmentioning

confidence: 99%

Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation

Hou

et al. 2023

Polymers for Advanced Techs

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“…Gemini surfactants have found application in medicine, physics, optics, and electronics. Polymerizable gemini anionic surfactants also have been synthesized to improve its interfacial properties [96]. These surfactants have been used as a template for the synthesis of nanoparticles.…”

Section: Applicationsmentioning

confidence: 99%

Gemini and Bicephalous Surfactants: A Review on Their Synthesis, Micelle Formation, and Uses

Guerrero-Hernández¹,

Meléndez‐Ortiz²,

Cortez-Mazatan³

et al. 2022

IJMS

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The use of surfactants in polymerization reactions is particularly important, mainly in emulsion polymerizations. Further, micelles from biocompatible surfactants find use in pharmaceutical dosage forms. This paper reviews recent developments in the synthesis of novel gemini and bicephalous surfactants, micelle formation, and their applications in polymer and nanoparticle synthesis, oil recovery, catalysis, corrosion, protein binding, and biomedical area, particularly in drug delivery.

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“…Polymerizable gemini surfactants have the abovementioned excellent interfacial activities and efficiently create cross-linked structures through the polymerization of the multiple double bonds. This ensures efficient stabilization of the micellar and liquid crystalline structures. − Our group has reported that monodisperse nanometer-sized spherical particles and vesicular or tubular hollow assemblies were prepared using T-type polymerizable cationic and anionic gemini surfactants. ,, Gin and co-workers succeeded in stabilizing hexagonal (H 1 ) and type I bicontinuous cubic (Q 1 ) mesophases of the lyotropic liquid crystal. These were efficiently formed by the polymerization of T-type gemini surfactants containing phosphonium or ammonium head groups. , However, the materials based on the hexagonal (H 1 ) phase are just assemblies of cylindrical objects.…”

Section: Introductionmentioning

confidence: 99%

Phase Behavior and Polymerization of the Ternary Polymerizable Cationic Gemini Surfactant/Fatty Alcohol/Water System

et al. 2020

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We studied the phase behavior of a ternary polymerizable gemini surfactant (PC11-6-11)/1-undecanol/water system and stabilized these liquid crystalline structures through the polymerization of surfactants. The addition of 1-undecanol to a PC11-6-11/water system formed bicontinuous cubic (V1) and reversed hexagonal (H2) liquid crystal phases in addition to hexagonal (H1) and lamellar (Lα) phases, which were also formed using the binary system of PC11-6-11/water. These new phases were formed because the fatty alcohol penetrated the palisade layer of the PC11-6-11 micelles. The polymerization of PC11-6-11 with a thermal initiator successfully preserved the Lα and H2 phases. Layered or honeycomb structures of these liquid crystals were clearly observed by transmission electron microscopy. The nanomaterials have potential applications as membranes for nano- or microfiltration and catalyst support materials.

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Polymerizable Anionic Gemini Surfactants: Physicochemical Properties in Aqueous Solution and Polymerization Behavior

Cited by 10 publications

References 21 publications

Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation

Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation

Gemini and Bicephalous Surfactants: A Review on Their Synthesis, Micelle Formation, and Uses

Phase Behavior and Polymerization of the Ternary Polymerizable Cationic Gemini Surfactant/Fatty Alcohol/Water System

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Polymerizable Anionic Gemini Surfactants: Physicochemical Properties in Aqueous Solution and Polymerization Behavior

Cited by 10 publications

References 21 publications

Curcumin‐loaded nanoparticle based on poloxamer188 for glioma treatment: Synthesis, characterization and in vitro evaluation

Curcumin‐loaded nanoparticle based on poloxamer188 for glioma treatment: Synthesis, characterization and in vitro evaluation

Gemini and Bicephalous Surfactants: A Review on Their Synthesis, Micelle Formation, and Uses

Phase Behavior and Polymerization of the Ternary Polymerizable Cationic Gemini Surfactant/Fatty Alcohol/Water System

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Product

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Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation

Curcumin‐loaded nanoparticle based on poloxamer₁₈₈ for glioma treatment: Synthesis, characterization and in vitro evaluation