Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Michalak, Grzegorz; Głuszek, Katarzyna; Piktel, Ewelina; Deptuła, Piotr; Puszkarz, Irena; Niemirowicz, Katarzyna; Bucki, Robert

doi:10.5114/ms.2016.58807

Cited by 28 publications

(11 citation statements)

References 55 publications

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“…In effect, multifunctional molecules are obtained. One of these solutions is the application of drug delivery systems containing metallic nanocarriers, for example, silver, gold or iron oxide magnetic nanoparticles (MNP) [118,119]. The above-listed nanoparticles possess proved antimicrobial activity, however, among them, MNP offers a great promise in the development of modern medical applications.…”

Section: Artificial Salivamentioning

confidence: 99%

Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

Łysik

Niemirowicz-Laskowska

Bucki

et al. 2019

IJMS

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The chronic sensation of a dry mouth is a disease condition called xerostomia and affects a large part of the population. Xerostomia is associated with decreased secretion, or more often, qualitative changes in saliva proteins and immunoglobulin concentrations that develop as a result of salivary gland dysfunction. Several reasons causing dry mouth were described, and usually, they include taking medications, diseases or radiotherapy. In some situations, when it is difficult to use salivary stimulants or salivary gland damage is irreversible, the only option might seem to be saliva substitutes. The paper presents the most important aspects considering saliva preparations. The rheological and lubricating properties and the reconstruction of the complex saliva structure has been the main purpose of research. The biological properties of saliva preparations were also widely discussed. As part of the work, the antimicrobial effect of three commercial saliva preparations was tested. Finally, inadequate antimicrobial properties against the strains isolated from the oral cavity were demonstrated. The development of salivary substitutes, in particular, the improvement of antimicrobial properties, can be achieved using nanotechnology, including drug delivery systems containing nanocarriers.

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Section: Artificial Salivamentioning

confidence: 99%

Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

Łysik

Niemirowicz-Laskowska

Bucki

et al. 2019

IJMS

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“…The exclusion of fluoroquinolones from routine treatment in outpatient therapy and searching for alternatives should be considered. The application of fluoroquinolones is becoming increasingly questionable and the limitation of their use is promoted by many scientists [7,[9][10][11][12]48,49]. In turn, ciprofloxacin induced cross-resistance to the smallest number of antibiotics in comparison to others.…”

Section: Antibiotics Induce Different Antibiotic Susceptibility Changesmentioning

confidence: 99%

Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic Escherichia coli strains

et al. 2019

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Antibiotic therapy and its consequences in bacterial and human aspects are widely investigated. Despite this, the emergence of new multidrug resistant bacteria is still a current problem. The scope of our work included the observation of changes among uropathogenic Escherichia coli strains after the treatment with a subinhibitory concentration of different antibiotics. The sensitive strains with or without virulence factors were incubated with amoxicillin, ciprofloxacin, gentamycin, or tobramycin. After each passage, the E. coli derivatives were compared to their wild types based on their susceptibility profiles, virulence genes, biofilm formations and the fingerprint profiles of PCR products amplified with using the (N)(6)(CGG)(4) primer. It turned out that antibiotics caused significant changes in the repertoire of bacterial virulence and biofilm formation, corresponding to acquired cross-resistance. The genomic changes among the studied bacteria were reflected in the changed profiles of the CGG-PCR products. In conclusion, the inappropriate application of antibiotics may cause a rapid rise of Multidrug Resistant (MDR) strains and give bacteria a chance to modulate their own pathogenicity. This phenomenon has been easily observed among uropathogenic E. coli strains and it is one of the main reasons for recurrent infections of the urinary tract.

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“…19,20 Studies show that the immobilization/encapsulation process improves the overall biological effectiveness of active agents including pharmacokinetic parameters (bioavailability, clearance) and reduces the side effects. [21][22][23] In addition, it has been noted that the antibiotic resistance of drug-resistant pathogens may be overcome by using nanoparticles as antibiotic carriers. 24 Among the many types of nanostructures, core-shell magnetic iron oxide nanoparticles are the most commonly used drug carriers in biomedical studies.…”

mentioning

confidence: 99%

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

Tokajuk

Niemirowicz

Deptuła

et al. 2017

IJN

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Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX). In the presence of human saliva, MNPs@CHX displayed significantly greater bactericidal and fungicidal activity against planktonic and biofilm-forming microorganisms than free CHX. In addition, CHX attached to MNPs has an increased ability to restrict the growth of mixed-species biofilms compared to free CHX. The observed depolarization of mitochondria in fungal cells treated with MNP@CHX suggests that induction of oxidative stress and oxidation of fungal structures may be a part of the mechanism responsible for pathogen killing. Nanoparticles functionalized by CHX did not affect host cell proliferation or their ability to release the proinflammatory cytokine, IL-8. The use of MNPs as a carrier of CHX has great potential for the development of antiseptic nanosystems.

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Polymeric nanoparticles – a novel solution for delivery of antimicrobial agents

Cited by 28 publications

References 55 publications

Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

Artificial Saliva: Challenges and Future Perspectives for the Treatment of Xerostomia

Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic Escherichia coli strains

Use of magnetic nanoparticles as a drug delivery system to improve chlorhexidine antimicrobial activity

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