Polymeric nano-micelles using poly(ethylene glycol) and poly(trimethylene carbonate) diblock copolymers as a drug carrier

A Review of the Potential Role of Nano-Enabled Drug Delivery Technologies in Amyotrophic Lateral Sclerosis: Lessons Learned from Other Neurodegenerative Disorders

“…119 These are formed from amphiphilic block copolymers consisting of hydrophilic and hydrophobic portions. 121 biomaterial (hydrogel) to form a dual drug delivery system. 103 Hydrogels have been developed to be utilized in the treatment of CNS disorder, 104 however, in combination with nanoparticles, the functions of both the nanoparticles and the hydrogel could be enhanced.…”

Preparation and characterization of polymeric micelles consisting of poly(propylene glycol) and poly(caprolactone) as a drug carrier

“…Several groups have focused on the preparation of polymeric micelles using amphiphilic block copolymers [3,4]. The solution properties of micelles such as the micelle size and the critical micelle concentration (CMC) can be mainly affected by the chemical composition and the structural architecture of the amphiphilic block copolymer [5].…”

Safety Evaluation of Amphiphilic Three-Armed Star-Shaped Copolymer Micelles

“…Now great attention is paid to biodegradable amphiphilic polymers especially self‐assembled micelles, because polymeric micelles have various advantages, such as particles with nanoscale, good permeation efficiency in the vicinity of solid tumors, the tunable physicochemical, biological properties, and diversified structures of block copolymers 10–13. Currently, more attention should be paid to amphiphilic micelles, which would not only stabilize the hydrophobic drugs with limited water solubility but also decrease their eventual high toxicity to healthy cells 14–16…”