Safety Evaluation of Amphiphilic Three-Armed Star-Shaped Copolymer Micelles

Wang, Xiuhong; Kan, Bing; Wang, Yujun; Dong, Pinliang; Shi, Shuai; Guo, Gang; Zhao, Yinglan; Luo, Feng; Zhao, Xia; Wei, Yuquan; Zhang, Qian

doi:10.1002/jps.22042

Cited by 11 publications

(7 citation statements)

References 34 publications

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“…However, as polylactide (PLA) and polylactide‐ co ‐glycolide (PLGA) particles widely used in drug delivery, micro/nanoscaled particles fabricated with poly(CPP : SA) possessed hydrophobic surfaces that led to their rapid removal by the immune system and poor resuspension and aerosolization properties 9. In parallel, polymeric micelles formed by self‐assembly of amphiphilic graft or block copolymers exerted many merits, such as biocompatibility, high drug‐loaded amount, and markedly improved bio‐distribution 10–12. Polymeric micelles have unique core‐shell architecture consisted of hydrophobic segments as internal core and hydrophilic segments as surrounding corona in aqueous medium.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

Zhao

Zhou

Chen

et al. 2010

J of Applied Polymer Sci

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A series of amphiphilic poly(ether-anhydrides) terpolymers composed of sebacic acid, 1,3-bis(carboxyphenoxy) propane, and poly(ethylene glycol) (PEG) were synthesized via melt-condensation polymerization. The resultant terpolymers were characterized by 1 H-nuclear magnetic resonance spectroscopy ( 1 H-NMR), Fourier transform infrared spectroscopy, gel permeation chromatography, X-ray diffraction, polarization optical microscope, differential scanning calorimeter, and water contact angle. Biodegradable micelles were prepared via a precipitation method through self-emulsification. The shape of these micelles was uniform and spheric according to the atomic force microscopy and transmission electron microscopy images. The dynamic light scattering measurements indicated that the diameters of micelles were typically in the range of 118-359 nm. The results displayed the PEG-based ether-anhydride terpolymers may be of great potential as nanoscaled carriers for drug delivery system.

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Section: Introductionmentioning

confidence: 99%

Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

Zhao

Zhou

Chen

et al. 2010

J of Applied Polymer Sci

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“…When the mice were sacrificed, the samples were obtained from the following organs: heart, liver, spleen, lung, and kidneys . All samples were fixed in 10% buffered formaldehyde and were subsequently embedded in paraffin, and then paraffin sections were stained with hematoxylin‐eosin for histopathological examination.…”

Section: Methodsmentioning

confidence: 99%

In Vitro and In Vivo Safety Evaluation of Biodegradable Self-Assembled Monomethyl Poly (Ethylene Glycol)–Poly(ε-Caprolactone)–Poly (Trimethylene Carbonate) Micelles

Yang

Cao

Wang

et al. 2014

Journal of Pharmaceutical Sciences

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“…Refering to the similar method adopted by the previous report [31], data obtained from our tests were analyzed by using SPSS software. All quantitative data were expressed as “mean value ± standard deviation”, and a value of P ≤ 0.05 was considered as significantly different.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid

Tan

Song

et al. 2013

BioMed Research International

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A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solvent by heat-initiated free radical method. The obtained macromonomers and hydrogels were characterized by 1H NMR and FT-IR, respectively. Morphology study of hydrogels was also investigated in this paper, and it showed that the hydrogels had good pH-sensitivity. The acute toxicity test and histopathological study were conducted in BALB/c mice. The results indicated that the maximum tolerance dose of the hydrogel was higher than 10000 mg/kg body weight. No morality or signs of toxicity were observed during the whole 7-day observation period. Compared to the control groups, there were no important adverse effects in the variables of hematology routine test and serum chemistry analysis both in male or female treatment group. Histopathological study also did not show any significant lesions, including heart, liver, lung, spleen, kidney, stomach, intestine, and testis. All the results demonstrated that this hydrogel was nontoxic after gavage. Thus, the hydrogel might be the biocompatible potential candidate for oral drug delivery system.

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Safety Evaluation of Amphiphilic Three-Armed Star-Shaped Copolymer Micelles

Cited by 11 publications

References 34 publications

Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

In Vitro and In Vivo Safety Evaluation of Biodegradable Self-Assembled Monomethyl Poly (Ethylene Glycol)–Poly(ε-Caprolactone)–Poly (Trimethylene Carbonate) Micelles

Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid

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