Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

Zhao, Aijun; Zhou, Qi; Chen, Tao; Weng, Jie; Zhou, Shaobing

doi:10.1002/app.32724

Cited by 19 publications

(8 citation statements)

References 34 publications

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“…Preparation of Blank and DOX‐loaded Micelles : The amphiphilic poly(PEG:SA:CPP) terpolymers composed of SA, CPP and PEG were synthesized via melt‐condensation polymerization per our previous report 57. The blank micelles were fabricated by using a solvent evaporation method 58.…”

Section: Methodsmentioning

confidence: 99%

A Strategy in The Design of Micellar Shape for Cancer Therapy

Chen

Guo

Liu

et al. 2012

Adv Healthcare Materials

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For cancer therapy, optimization of carrier features is necessary to effectively deliver the targeting agents to tumor sites. Biodegradable poly(ether-anhydrides) micelles with filamentous, rod-like, and spherical shapes are fabricated. Their size and morphology are characterized by AFM and TEM. The encapsulation of doxorubicin hydrochloride (DOX) into the micelles does not impact their shape. The effect of micellar shape on the drug loading capacity and encapsulation efficiency, as well as in vitro drug release, is investigated. The cellular uptakes are evaluated using fluorescence microscopy, confocal laser scanning microscopy and flow cytometry on co-cultures of human hepatoblastoma cell line (HepG2), lung epithelial cancer cell line (A549), and human nasopharyngeal epidermoid carcinoma cells (KB) and fibroblast normal cells mixed with the different shapes of DOX-loaded micelles. The results show that the spherical DOX-loaded micelles are more readily taken up by all types of cells. The impact of micellar shape on in vivo antitumor function is also assessed from changes of tumor volume, body weight loss, and survival rate of 4T1-bearing mice and the immunostaining of tumor sections for analysis of tumor cell proliferation. The results reveal that the filamentous DOX-loaded micelles possess the highest safety to body and the best therapeutic effects to artificial solid tumors. Therefore, the filamentous shape is deemed the most suitable morphology for design and engineering of drug vehicles for cancer therapy.

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Section: Methodsmentioning

confidence: 99%

A Strategy in The Design of Micellar Shape for Cancer Therapy

Chen

Guo

Liu

et al. 2012

Adv Healthcare Materials

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“…The peaks at 3.79, 3.84, and 3.86 ppm are indexed to the protons on OCH 3 groups, and the chemical shifts at 6. 64-6.66, 6.75, 7.03, 7.04, 7.86, and 7.87 ppm (Figure 3E) are ascribed to other protons in Prazosin, which confirm a successful conjugation (Zhao et al, 2010).…”

Section: Characterization Of the Synthesized Polymersmentioning

confidence: 67%

Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

Fattahi

Ghiasi

Mohammadi

et al. 2018

Braz. J. Pharm. Sci.

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In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1 H-NMR. Flutamide-loaded nanoparticles were prepared by quasi-emulsion solvent diffusion technique. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency, and release properties. Also, the physicochemical properties of the nanoparticles were analyzed using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry, and Powder X-Ray Diffractometry (XRD). The particle size of nanoparticles was ranged between 191 and 249 nm. Loading efficiency of nanoparticles was about 43%-69%. Results showed a steady release rate for nanoparticles compared to that of a pure drug powder. SEM characterization confirmed that particles were in nanosize range. DSC and XRPD results verified a decrease in drug crystallinity in the prepared formulations. In conclusion, the results of this study showed that PLGA-PEG-Praz nanoparticles could be a good choice to improve the physicochemical properties of the drug and these formulations can increase Flutamide efficacy.

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“…Fig. 1 6 /TMS, (ppm)]: 9.9 (s, 1H), 8.9 (s, 1H), 6.9e7.9 (m, 4H), 3.9 (m, 2H), 2.6 (s, 3H), 1.6 (s, 3H). …”

Section: Terpolymerizationmentioning

confidence: 99%

Preparation and thermal studies of self-crosslinked terpolymer derived from 4-acetylpyridine oxime, formaldehyde and acetophenone

Chauhan¹,

Ameta²

2011

Polymer Degradation and Stability

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Amphiphilic PEG‐based ether‐anhydride terpolymers: Synthesis, characterization, and micellization

Cited by 19 publications

References 34 publications

A Strategy in The Design of Micellar Shape for Cancer Therapy

A Strategy in The Design of Micellar Shape for Cancer Therapy

Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide

Preparation and thermal studies of self-crosslinked terpolymer derived from 4-acetylpyridine oxime, formaldehyde and acetophenone

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