Preparation and characterization of polymeric micelles consisting of poly(propylene glycol) and poly(caprolactone) as a drug carrier

Lee, Sang Hyo; Oh, Jae Min; Son, Jin Soo; Lee, Jae Hyeok; Kim, Jae Il; Kwon, Doo Yeon; Lee, Bong; Kim, Jae Ho; Kim, Moon Suk

doi:10.1109/inec.2010.5424831

Cited by 1 publication

(1 citation statement)

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“…Propylene glycol is a colorless and odorless alcohol compound that has been used as a solvent and a drug carrier in pharmaceutical products (Ooya and Yui 2000; Kogan and Garti 2006; Lee, Oh et al 2010). ISOVUE 370 is a contrast agent containing iodine used in radiological examinations.…”

Section: Experimental Methodsmentioning

confidence: 99%

A MEMS electrochemical bellows actuator for fluid metering applications

Sheybani

Gensler

Meng

2012

Biomed Microdevices

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We present a high efficiency wireless MEMS electrochemical bellows actuator capable of rapid and repeatable delivery of boluses for fluid metering and drug delivery applications. Nafion®-coated Pt electrodes were combined with Parylene bellows filled with DI water to form the electrolysis-based actuator. The performance of actuators with several bellows configurations was compared for a range of applied currents (1-10 mA). Up to 75 boluses were delivered with an average pumping flow rate of 114.40 ± 1.63 μL/min. Recombination of gases into water, an important factor in repeatable and reliable actuation, was studied for uncoated and Nafion®-coated actuators. Real-time pressure measurements were conducted and the effects of temperature, physiological back pressure, and drug viscosity on delivery performance were investigated. Lastly, we present wireless powering of the actuator using a class D inductive powering system that allowed for repeatable delivery with less than 2% variation in flow rate values.

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Section: Experimental Methodsmentioning

confidence: 99%