Polymeric micelles functionalized with cell penetrating peptides as potential pH-sensitive platforms in drug delivery for cancer therapy: A review

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

“…It should be explored whether the targeting potential of NPs pre-covered by a PC could be changed by the non-specific attachment of a high abundance of plasma components. It was found that precoating of NPs with γ-globulins could increase the feasible adsorption of opsonins [105,106], whereas pre-coating with HSA, could mitigate the attachment of opsonins onto NPs [107] and improve colloidal stability and probable cellular internalization [108,109]. It was then found that NPs pre-coated with γ-globulins were entirely covered with some opsonins (immunoglobulins and complement factors) [105].…”

The Therapeutic Applications Of Aptamers And Aptamer-Conjugated Nanoparticles In Cancer, Inflammatory And Viral Diseases

“…Modified nucleotides before or after the SELEX round, mirror image aptamers, and aptamer displacement screening are typically utilized to address this issue. The pharmacokinetics of the aptamer in blood can be improved, for instance, by altering the 20 sugar position (20 -amino pyrimidine nucleosides [20,21], 20 -fluoropyrimidine nucleosides [22,23], 20 -Omethyl purine, and 20 -O-methyl pyrimidine nucleosides [24,25]) or 30 and 50 nucleotides, which are located L-Regarding the second issue, renal aptamer filtration, conjugation with polyethylene glycol (PEG) and, as a result, larger aptamer size is a good way to lengthen the time it takes for blood to circulate in the body. The use of polycationic biopolymers like porphyrin and the transformation of an inactive aptamer into an active form are the most common solutions to the third issue related to aptamer control action duration.…”

“…[18] Hybrid nanostructures have the potential to be effective active targeting materials due to the rapid development of nanotechnology and the crucial needs of selective suppression of cancer cell proliferation at the beginning phases of growth. [19,20] Actually, according to, the capacity of aptamers to recognise particular epitopes on cell surfaces can lead to enhanced medication accumulation inside cancer cells. [7,12] Additionally, we provided a summary of recent developments in the creation of aptamer-NPs complexes that can deliver anticancer medications to a particular tumour site.…”

Amphiphilic Micelles as Superior Nanocarriers in Drug Delivery: from Current Preclinical Surveys to Structural Frameworks

“…The micelles of individual drugs and mixed PTX/RAP are formed by conjugation of drugs in a polyethylene glycol block‐ poly‐β, benzyl L‐ aspartate by pH based sensitive linker. These micelles deliver this drug at pH 5.5 signifying better release in the acidic lysosomal/endosomal atmosphere shown in Figure 6 [125–127] . Micelles show anti proliferative effects on ovarian cancer cell lines (ovarian human Caucasian adenocarcinoma‐ SKOV‐3, clear human ovarian cell carcinoma‐E$2) and an endothelial cell line (human umbilical vein endothelial cell line‐HUVEC).…”

“…These micelles deliver this drug at pH 5.5 signifying better release in the acidic lysosomal/endosomal atmosphere shown in Figure 6. [125][126][127] Micelles show anti proliferative effects on ovarian cancer cell lines (ovarian human Caucasian adenocarcinoma-SKOV-3, clear human ovarian cell carcinoma-E$2) and an endothelial cell line (human umbilical vein endothelial cell line-HUVEC). Thus, micelles also introverted the migration of endothelial and tube formation.…”