Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Khan, Suliman; Sharifi, Majid; Gleghorn, Jason P.; Babadaei, Mohammad Mahdi Nejadi; Bloukh, Samir Haj; Edis, Zehra; Amin, Mohammadreza; Bai, Qian; Hagen, Timo L.M. ten; Falahati, Mojtaba; Cho, William C.

doi:10.1016/j.jconrel.2022.05.055

Cited by 32 publications

(21 citation statements)

References 223 publications

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“…The proteins contained in the protein corona layer will endow the nanozymes with in vivo biological identity, thus altering the in vivo biological properties of the nanozymes, such as toxicity and systemic distribution properties. [ 103 ] Generally speaking, plasma proteins are divided into two categories: Opsonins and dysopsonins. The non‐specific adsorption of opsonins (e.g., immunoglobulins and complement components) increases the uptake efficiency of nanomaterials by the reticuloendothelial phagocytic system and accelerates the clearance of nanomaterials.…”

Section: Strategies To Improve the Biocompatibility Of Nanozymesmentioning

confidence: 99%

Nanozymes for Regenerative Medicine

Mou

Zhang

et al. 2022

Small Methods

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Nanozymes refer to nanomaterials that catalyze enzyme substrates into products under relevant physiological conditions following enzyme kinetics. Compared to natural enzymes, nanozymes possess the characteristics of higher stability, easier preparation, and lower cost. Importantly, nanozymes possess the magnetic, fluorescent, and electrical properties of nanomaterials, making them promising replacements for natural enzymes in industrial, biological, and medical fields. On account of the rapid development of nanozymes recently, their application potentials in regeneration medicine are gradually being explored. To highlight the achievements in the regeneration medicine field, this review summarizes the catalytic mechanism of four types of representative nanozymes. Then, the strategies to improve the biocompatibility of nanozymes are discussed. Importantly, this review covers the recent advances in nanozymes in tissue regeneration medicine including wound healing, nerve defect repair, bone regeneration, and cardiovascular disease treatment. In addition, challenges and prospects of nanozyme researches in regeneration medicine are summarized.

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Section: Strategies To Improve the Biocompatibility Of Nanozymesmentioning

confidence: 99%

Nanozymes for Regenerative Medicine

Mou

Zhang

et al. 2022

Small Methods

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“…Opsonization, for instance, triggers clearance by mononuclear phagocytosis, while apolipoproteins and albumin, on the other hand, facilitate stealth effects of NPs and improve their delivery to specific organs. Many studies are being conducted in vitro with an attempt to direct the NP-corona composition to increase the drug delivery to tumor cells(Khan et al 2022 ), Though, further advancement in this field is still to be addressed.…”

Section: Bridging Drug Delivery To the Tumormentioning

confidence: 99%

Nanomedicines: intervention in inflammatory pathways of cancer

Anwar

Naqvi

Shams³

et al. 2023

Inflammopharmacol

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Inflammation is a complex defense process that maintains tissue homeostasis. However, this complex cascade, if lasts long, may contribute to pathogenesis of several diseases. Chronic inflammation has been exhaustively studied in the last few decades, for its contribution in development and progression of cancer. The intrinsic limitations of conventional anti-inflammatory and anti-cancer therapies triggered the development of nanomedicines for more effective and safer therapies. Targeting inflammation and tumor cells by nanoparticles, encapsulated with active therapeutic agents, offers a promising outcome with patient survival. Considerable technological success has been achieved in this field through exploitation of tumor microenvironment, and recognition of molecules overexpressed on endothelial cells or macrophages, through enhanced vascular permeability, or by rendering biomimetic approach to nanoparticles. This review focusses on the inflammatory pathways in progression of a tumor, and advancement in nanotechnologies targeting these pathways. We also aim to identify the gaps that hinder the successful clinical translation of nanotherapeutics with further clinical studies that will allow oncologist to precisely identify the patients who may be benefited from nanotherapy at time when promotion or progression of tumor initiates. It is postulated that the nanomedicines, in near future, will shift the paradigm of cancer treatment and improve patient survival. Graphical abstract

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“…In addition, the size, shape, surface charge, and material properties of nanoparticles play a key role in drug half-life and biological distribution ( Huang et al, 2022 ; Souri et al, 2022 ). Among them, the size and surface properties are key to the biological fate of NPs, as these parameters prevent them from being absorbed by mononuclear phagocyte system (MPS) ( Liu et al, 2022a ; Khan et al, 2022 ; Mills et al, 2022 ). A high curvature (resulting in a small size, < 100 nm) and/or a hydrophilic surface (as opposed to the hydrophobic surface of conventional nanoparticles) are needed to reduce opsonization reactions and subsequent clearance by macrophages ( Couvreur and Vauthier, 2006 ; Ren et al, 2022 ).…”

Section: Nanoparticlesmentioning

confidence: 99%

Biomimetic nanoparticles for tumor immunotherapy

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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Currently, tumor treatment research still focuses on the cancer cells themselves, but the fact that the immune system plays an important role in inhibiting tumor development cannot be ignored. The activation of the immune system depends on the difference between self and non-self. Unfortunately, cancer is characterized by genetic changes in the host cells that lead to uncontrolled cell proliferation and evade immune surveillance. Cancer immunotherapy aims to coordinate a patient’s immune system to target, fight, and destroy cancer cells without destroying the normal cells. Nevertheless, antitumor immunity driven by the autoimmune system alone may be inadequate for treatment. The development of drug delivery systems (DDS) based on nanoparticles can not only promote immunotherapy but also improve the immunosuppressive tumor microenvironment (ITM), which provides promising strategies for cancer treatment. However, conventional nano drug delivery systems (NDDS) are subject to several limitations in clinical transformation, such as immunogenicity and the potential toxicity risks of the carrier materials, premature drug leakage at off-target sites during circulation and drug load content. In order to address these limitations, this paper reviews the trends and progress of biomimetic NDDS and discusses the applications of each biomimetic system in tumor immunotherapy. Furthermore, we review the various combination immunotherapies based on biomimetic NDDS and key considerations for clinical transformation.

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Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

Cited by 32 publications

References 223 publications

Nanozymes for Regenerative Medicine

Nanozymes for Regenerative Medicine

Nanomedicines: intervention in inflammatory pathways of cancer

Biomimetic nanoparticles for tumor immunotherapy

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