Polymeric ionic liquid open tubular capillary column for on-line in-tube SPME coupled with UHPLC-MS/MS to determine endocannabinoids in plasma samples

High‐throughput microscale extraction using ionic liquids and derivatives: A review

“…Significant increase in the sample throughput of IL‐SPE is achieved when using online FI systems [32]. Representative applications using online IL‐μ‐SPE protocols are summarized in Table 1 [32–41]. For example, in a semi‐automatic flow system used for the extraction of a group of dyes in a remediation protocol, a nanocomposite composed by β‐cyclodextrin‐functionalized carbon nanotubes (CNTs) containing also TiO 2 nanoparticles (NPs), and ultimately modified with the 1‐octyl‐3‐methylimidazolium hexaflurophosphate ([C 8 MIM + ][PF 6 − ]) IL, was employed.…”

“…ILs and PILs have also been employed in in‐tube SPME mode [7,10]. In particular, a relatively large number of these applications performed the extraction/elution procedure online using a switchable six‐port injection valve directly connected to the analytical detection technique [35–40], as summarized in Table 1 [35–41]. In these cases, the sample loop of the valve was substituted for the in‐tube capillary containing the IL‐ or PIL‐sorbent material as shown in Figure 2B [38].…”

“…With this configuration, all the steps of the extraction procedure, including liquid desorption with organic solvents and eluate transport to the subsequent analytical detection technique, were undertaken automatically with the aid of the FI‐system. This type of configuration facilitated the combination of the in‐tube SPME method with HPLC [35–39]. In several of these applications, the HPLC mobile phase also served for the elution of the analytes from the capillary, and thus resulting in a simpler system configuration [35,37–39].…”

Triazine‐based organic polymers@SiO2 nanospheres for sensitive solid‐phase microextraction of polycyclic aromatic hydrocarbons

“…Among them, the combination of intube SPME and HPLC makes a possibility of high-throughput Article Related Abbreviations: DAD, diode array detector; EFs, enrichment factors; FLD, fluorescence detector; MSPE, magnetic solid-phase extraction; PEEK, polyetheretherketone; r, correlation coefficients; UVD, ultraviolet detector. Various materials with porosity, high specific surface area, and good adsorption properties have been fabricated for the efficient coatings of in-tube SPME such as carbon-based materials [17][18][19], metal-organic frameworks [20], nanomaterials [21], ionic liquids [22], and porous organic polymers. The extraction coating plays a critical role in sensitivity, capability, and repeatability.…”

“…The extraction coating plays a critical role in sensitivity, capability, and repeatability. Various materials with porosity, high specific surface area, and good adsorption properties have been fabricated for the efficient coatings of in-tube SPME such as carbon-based materials [17][18][19], metal-organic frameworks [20], nanomaterials [21], ionic liquids [22], and porous organic polymers.…”