Polymeric complex micelles with double drug-loading strategies for folate-mediated paclitaxel delivery

Li, Min; Liu, Yongjun; Feng, Lixia; Liu, Fengxi; Zhang, Li; Zhang, Na

doi:10.1016/j.colsurfb.2015.04.057

Cited by 30 publications

(8 citation statements)

References 24 publications

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“…By making use of folic acid, biotin, and CD44 receptors mediated targeting, the prepared ICA&Cur “nano-actiniaes” enhanced the stability of anti-cancer drugs, with accurate delivery of drugs to tumor tissue and cancer stem cells, thereby ameliorating anticancer efficacy. Moreover, ICA and Cur were released in the microenvironment of the tumor due to their connection to pH-sensitive hydrazone bond (Li et al., 2015). Additionally, the synthesis of Bio-oHA-Hyd-FA copolymer, preparation, and characterization of “nano-actiniaes”, cytotoxicity, transwell invasion assay and anti-tumor effect of “nano-actiniaes” in vivo were also examined in detail.…”

Section: Introductionmentioning

confidence: 99%

Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy

et al. 2019

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In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive “nano-actiniaes” were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy. The newly synthesized polymer oligomeric hyaluronic acid-hydrazone bond-folic acid-biotin (Bio-oHA-Hyd-FA) was characterized by 1H NMR spectrogram (proton nuclear magnetic resonance). The obtained drug carrier Bio-oHA-Hyd-FA self-assembled into nanomicelles, named as “nano-actiniaes”, in aqueous media with hydrodynamic diameter of 162.7 ± 5 nm. The size, surface zeta potential, and morphology of the “nano-actiniaes” were observed via TEM. The in vitro release experiment indicated that much more encapsulated icariin (ICA) and curcumin (Cur) were released from the Bio-oHA-Hyd-FA micelles (nano-actiniaes) in the acidic environment. Additionally, the cytotoxicity research demonstrated that the Bio-oHA-Hyd-FA carrier material was completely nontoxic, and the ICA&Cur “nano-actiniaes” had greater cytotoxicity compared with other control groups. In addition, the “nano-actiniaes” were found to significantly inhibit cancer cell invasion by Transwell assay. Moreover, in vivo evaluation of anti-tumor effect illustrated that the ICA and Cur “nano-actiniaes” possessed inhibitory effect on tumors. Consequently, the multi-targeted pH-sensitive “nano-actiniaes” can realize significant tumor targeting and effectively inhibit tumor growth.

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Section: Introductionmentioning

confidence: 99%

Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy

et al. 2019

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“…Folate receptors (FRs) can be overexpressed at elevated levels as a tumor marker [27][28][29], hence FA molecules can bind specifically to the FR-expressing tumor cells, presumably through FR-mediated endocytosis [30,31]. In addition, FA is attractive partly because of its ability to conjugate with various molecules, low cost, and high stability [32,33]. Therefore, protein MCs with targeting materials (Fe 3 O 4 MNPs or FA molecules) shall be a nice choice to develop the vehicles for specific delivery.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…24,37 In 2015, another group reported on the use of P123 to coat PTX, additionally linked with folate for targeted delivery. 33 However, the drug loading in the previously mentioned P123 designs is low. The novelty of our approach is a newly developed nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) to formulate PTX.…”

Section: Introductionmentioning

confidence: 99%

Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect

Chen

Patra³

et al. 2017

J Biomater Appl

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Surgery, chemotherapy, and radiotherapy are the three top cancer treatment modalities. Paclitaxel (PTX) is one of the most widely used chemotherapy drugs. However, its clinical applications have been significantly limited due to: (i) serious hemolysis effect of currently available commercial paclitaxel formulations and (ii) its water insolubility. An easy way to deliver paclitaxel by a new nanocarrier system using pluronic copolymers of P123/F68 and Sorbitan monopalmitate (Span 40) was reported in our previous research article. The characterization of the formulation and analysis of drug release and cellular uptake were also presented. In this article, we reported discoveries of our follow-up in vivo antitumor and in vitro hemolytic study discoveries. The experimental results showed that the nanoformulated PTX achieved much better tumor suppression performance while reducing hemolysis side effects. This newly formulated drug can significantly improve patient outcomes in cancer chemotherapy.

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Polymeric complex micelles with double drug-loading strategies for folate-mediated paclitaxel delivery

Cited by 30 publications

References 24 publications

Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy

Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy

Synthesis of multifunctional bovine serum albumin microcapsules by the sonochemical method for targeted drug delivery and controlled drug release

Nanoformulated water-soluble paclitaxel to enhance drug efficacy and reduce hemolysis side effect

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