Polymerase Chain Reaction of &lt;i&gt;Borrelia burgdorferi&lt;/i&gt; Flagellin Gene in Shulman Syndrome

Hashimoto, Yuichi; Takahashi, Hidetoshi; Matsuo, Shinobu; Hirai, Katsuyuki; Takemori, Nobuo; Nakao, Minoru; Miyamoto, Kenji; Iizuka, Hajime

doi:10.1159/000246339

Cited by 41 publications

(26 citation statements)

References 10 publications

(14 reference statements)

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“…An association with vigorous exercise in up to 66% [11, 14], trauma [7, 8, 17], simvastatin [3] and phenytoin [18], arthropod bites [6, 19], Borrelia infection [5, 20, 21], hematological malignancies [22,23,24] and thyroid diseases [25, 26] has been reported. …”

Section: Discussionmentioning

confidence: 99%

“…Serious hematological disorders and malignancies, such as aplastic anemia, immune thrombocytopenia, peripheral T-cell lymphoma, pure red cell aplasia, acquired thrombocytopenic purpura, Hodgkin and non-Hodgkin lymphoma, have been published [21, 36,55,56,57,58]. Patients with EF show a clearly elevated risk for hematological malignancies [59].…”

Section: Discussionmentioning

confidence: 99%

“…Serology for Borrelia should be obtained in every case, as this association was documented repeatedly [4, 5, 20, 21]. The literature also shows several cases, where living Borrelia was detected in biopsies [5, 20].…”

Section: Discussionmentioning

confidence: 99%

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Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Antic¹,

2006

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Background: Eosinophilic fasciitis (EF) is a rare fibrosing disorder associated with peripheral eosinophilia and scleroderma-like induration of the distal extremities which affects substantially quality of life. Although the disease has been described 30 years ago, the etiology and pathomechanisms are still obscure, and consensus for therapy is lacking. Numerous case reports of patients with EF exist but series are scarce. Patients and Methods: Eleven patients with EF from the Department of Dermatology, Kantonsspital Aarau, the University Hospital Basel and the Outpatient Clinic of Dermatology, Triemli Hospital Zurich, Switzerland, were retrospectively studied. Results: In 4 patients the initial diagnosis was not recognized by the referring nondermatologists. The median age was 55 years, excluding the youngest patient ever diagnosed with EF (age = 1 year). All patients showed an induration of the skin, which led to painful contractures in the joints in 3 cases. All but 2 patients demonstrated edema. A slight predominance of the upper extremities was observed. Sclerodactyly was noticed in 1 patient. Three patients reported an initial trauma at the affected site. Two patients were tested positive for borreliosis. One patient subsequently developed aplastic anemia and Hashimoto thyroiditis. Visceral or extracutaneous involvement was absent. Eight patients had a full or partial recovery under corticosteroids whereas in 2, improvement could be achieved only with cyclosporine, azathioprine or cyclophosphamide. Conclusions: The diagnosis of EF can be established by clinical, laboratory and histological findings. In general, corticosteroids are highly efficacious in EF and only a minority of patients need other immunosuppressive or cytostatic drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Antic¹,

2006

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“…burgdorferi has been reported and spirochetal organisms have been identified in some EF lesions (36,37). However, these findings have not been consistently reproduced (38).…”

Section: Etiopathogenesismentioning

confidence: 99%

Scleroderma-like Fibrosing Disorders

Boin¹,

Hummers²

2008

Rheumatic Disease Clinics of North America

109

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SynopsisMany conditions presenting with clinical hard skin and tissue fibrosis can be confused with systemic sclerosis (scleroderma). These disorders have very diverse etiologies and often an unclear pathogenetic mechanism. Distinct clinical characteristics, skin histology and disease associations may allow to distinguish these conditions from scleroderma and from each other. A prompt diagnosis is important to spare the patients from ineffective treatments and inadequate management. In this review, we highlighted nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy), eosinophilic fasciitis (Shulman's syndrome), scleromyxedema and scleredema. These are often detected in the primary care setting and referred to rheumatologists for further evaluation. Rheumatologists must be able to promptly recognize them to provide valuable prognostic information and appropriate treatment options for affected patients.

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“…Furthermore, PCR techniques have been used to demonstrate B. burgdorferi DNA in tissues of patients with dermatomyositis (45,64,67) and in patients with eosinophilic fasciitis (Shulman's syndrome) (53,60).…”

Section: Patients With Dermatological Manifestationsmentioning

confidence: 99%

Methodological Aspects

1985

Journal of Internal Medicine

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Polymerase Chain Reaction of <i>Borrelia burgdorferi</i> Flagellin Gene in Shulman Syndrome

Cited by 41 publications

References 10 publications

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Eosinophilic Fasciitis 30 Years after – What Do We Really Know?

Scleroderma-like Fibrosing Disorders

Methodological Aspects

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