Polymer hydrogel interfaces in electrochemical sensing strategies: A review

Dhanjai,; Sinha, Ankita; Kalambate, Pramod K.; Mugo, Samuel M.; Kamau, Patrick; Chen, Jiping; Jain, Rajeev

doi:10.1016/j.trac.2019.06.014

Cited by 84 publications

(38 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The readout is typically accomplished optically with or without labeling, electrochemically, or by determining the mass change. [7,35,36] Examples of commonly used biosensors are glucose monitoring devices for diabetic patients and pregnancy tests, which detect human chorionic gonadotropin in urine. Besides these, biosensors are not only applied in health care but play an important role in crime detection, environmental field monitoring, and food analysis.…”

Section: Biosensingmentioning

confidence: 99%

Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

144

126

View full text Add to dashboard Cite

Hydrogels play an important role in the field of biomedical research and diagnostic medicine. They are emerging as a powerful tool in the context of bioanalytical assays and biosensing. In this context, this review gives an overview of different hydrogels and the role they adopt in a range of applications. Not only are hydrogels beneficial for the immobilization and embedding of biomolecules, but they are also used as responsive material, as wearable devices, or as functional material. In particular, the scientific and technical progress during the last decade is discussed. The newest hydrogel types, their synthesis, and many applications are presented. Advantages and performance improvements are described, along with their limitations.

show abstract

Section: Biosensingmentioning

confidence: 99%

Hydrogels and Their Role in Biosensing Applications

Herrmann

Haag

Schedler

2021

Adv Healthcare Materials

144

126

View full text Add to dashboard Cite

show abstract

“…Recently, there are many reviews about hydrogel-based biomolecule detection, such as antigen-antibody immunoassay [11], electrochemical detection [12], disease specific gene [7] involved glucose detection, or photonic crystal hydrogel [4], portable electrochemical sensor [13] involved hydrogel-based devices, however, there is no systematic summary analysis on the detection of glucose on the basis of stimuli-responsive phase transition of hydrogel, therefore, this review will give a systematic description of the glucose detection in recent years: part 1, the preparation of hydrogels, based on the glucose-sensitive pattern; part 2, the glucose detection mechanism, based on the signal transduction mechanism; part 3, current and emerging devices, based on the body fluid type; part 4, discussing the challenge and prospecting the future development trend.…”

Section: Introductionmentioning

confidence: 99%

Recent Applications of Point-of-Care Devices for Glucose Detection on the Basis of Stimuli-Responsive Volume Phase Transition of Hydrogel

Gao

You

2021

BioChip J

View full text Add to dashboard Cite

Diabetes is a serious global disease that threatens more than 400 million people's health. Therefore, timely detection of body's glucose level becomes extremely important for control, diagnosis and treatment of diabetes. Based on the feature of stimuli-responsive volume phase transition of hydrogel materials, this review will provide a systematic summary of glucose detection devices in recent years, including hydrogel preparation methods based on glucose-sensitive pattern, detection mechanisms based on signal transduction, current and emerging devices based on different body fluids and discuss the challenge, prospect the future development trend in the end.

show abstract

“…Hydrogels composed of 3D crosslinked hydrophilic polymer networks have gained much attention recently as building materials in the construction of electrochemical and ECL biosensing systems. [ 17 ] The highly porous structure of hydrogels allows the efficient immobilization of ECL probes, and also allows the rapid diffusion of small molecular ECL co‐reagents and biotargets. [ 18,19 ] The introduction of conductive polymers or nanostructures into the hydrogel networks can enhance the sensitivity of the systems, [ 20–22 ] and the introduction of responsive structures can endow the system tunable and responsive ECL properties.…”

Section: Introductionmentioning

confidence: 99%

“…The porous structure of hydrogel matrix can prevent macromolecular substances, such as proteins, from contacting and contaminating the electrode surface, and, by introducing non‐covalent crosslinking mechanisms, such as hydrogen bonding, hydrophobic interaction, electrostatic interaction or physical entanglement of polymer chains, the hydrogel can exhibit self‐healing properties. [ 16,17 ] Therefore, it is highly expected to develop hydrogel based ECL biosensing system that exhibited anti‐biofouling and self‐healing properties simultaneously. Among the materials that can form hydrogels, proteins with excellent intrinsic biocompatibility can be utilized to fabricate physically crosslinked hydrogels through very simple processes.…”

Section: Introductionmentioning

confidence: 99%

Fluorescent Noble Metal Nanoclusters Loaded Protein Hydrogel Exhibiting Anti‐Biofouling and Self‐Healing Properties for Electrochemiluminescence Biosensing Applications

Han

Guo

2020

Small

View full text Add to dashboard Cite

analytical method over the past few decades, and holds great promise in various analytical application fields, especially in the analysis of biological samples. [1-3] By far, remarkable efforts have been made to develop various types of ECL based biosensing systems, [4,5] and the recent introduction of new ECL materials or mechanisms, such as metal-organic frameworks, aggregation-induced emission luminogens or single atom catalysts, further improved the performance and application ranges of ECL based biosensing systems. [6-11] However, as a method extremely sensitive to the state of the electrode surface, nonspecific adsorption of biological macromolecules, in particular proteins, and physical scratches of the electrode surfaces, during the sensing of complex biological samples, severely affects the accuracy and practical applicability of the ECL biosensing systems. [12] In order to meet the requirements of anti-interference and long-term application in practical biosensing applications, it is highly demanded to develop ECL biosensing systems with anti-biofouling and self-healing properties. Although some efforts have been made to enhance the anti-biofouling property of ECL biosensing systems, for example, the introduction of hydrophilic polymers or biopolymers to construct protein-resistant anti-fouling electrode surfaces, these methods still encounter the disadvantages such as poor conductivity and complicated synthesis procedures. [13-15] Furthermore, few studies worked on the development of ECL biosensing system exhibiting self-healing properties, or, even more, ECL sensing systems exhibiting anti-biofouling and selfhealing properties simultaneously. [16] Therefore, the construction of ECL biosensing systems exhibiting both antifouling and self-healing properties is highly desired and of great importance for practical biological applications. Hydrogels composed of 3D crosslinked hydrophilic polymer networks have gained much attention recently as building materials in the construction of electrochemical and ECL biosensing systems. [17] The highly porous structure of hydrogels allows the efficient immobilization of ECL probes, and also Electrochemiluminescence (ECL) showed great potential in various analytical applications, especially in the sensing of biotargets, taking advantage of its high sensitivity, selectivity, ease of spatial and temporal control, and simplified optical setup. However, during the sensing of complex biological samples, ECL sensors often suffered severe interferences from unavoidable nonspecific-binding of biomacromolecules and physical damages of ECL sensing interfaces. Herein, a hydrogel based ECL biosensing system exhibiting excellent anti-biofouling and self-healing properties is developed. A protein hydrogel composed of bovine serum albumin (BSA) directed fluorescent Au/Ag alloy nanoclusters (Au/Ag NCs) is applied in building ECL sensing systems. The hydrogel matrix facilitates the immobilization of fluorescent Au/Ag NCs as excellent ECL probes, and the porous hydrophilic structure a...

show abstract

Polymer hydrogel interfaces in electrochemical sensing strategies: A review

Cited by 84 publications

References 69 publications

Hydrogels and Their Role in Biosensing Applications

Hydrogels and Their Role in Biosensing Applications

Recent Applications of Point-of-Care Devices for Glucose Detection on the Basis of Stimuli-Responsive Volume Phase Transition of Hydrogel

Fluorescent Noble Metal Nanoclusters Loaded Protein Hydrogel Exhibiting Anti‐Biofouling and Self‐Healing Properties for Electrochemiluminescence Biosensing Applications

Contact Info

Product

Resources

About