Hydrogels and Their Role in Biosensing Applications

Abstract

Hydrogels play an important role in the field of biomedical research and diagnostic medicine. They are emerging as a powerful tool in the context of bioanalytical assays and biosensing. In this context, this review gives an overview of different hydrogels and the role they adopt in a range of applications. Not only are hydrogels beneficial for the immobilization and embedding of biomolecules, but they are also used as responsive material, as wearable devices, or as functional material. In particular, the scientific and technical progress during the last decade is discussed. The newest hydrogel types, their synthesis, and many applications are presented. Advantages and performance improvements are described, along with their limitations.

Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications

“…Hydrogels might be utilized as bio detecting component immobilization lattices and give ideal conditions to proteins and other biomolecules to keep up with their dynamic and practical construction. The cooperation among analyte and sensing components causes a volume change in light of the objective part, and this volume change is the reason for ID in hydrogel-based sensors [ 128 , 129 , 130 ].…”

Supramolecular Hydrogels: Design Strategies and Contemporary Biomedical Applications

“…Other biomedical applications which require more extensive research while utilising supramolecular hydrogels, include but are not limited to biosensors and bioanalytical detection techniques. [227] Although the applications of hydrogels are numerous, these materials are not without limitations. Routes to overcome these challenges are highlighted in Table 2.…”

Microneedle-Based Device for Biological Analysis

“…Hydrogels are biocompatible and biodegradable. They are able to cause minimal tissue damage and little environmental threat after disposal ( Herrmann et al, 2021 ). Chang et al (2017) developed a methacrylated hyaluronic acid (MeHA)-based swellable MN platform, which can extract ISF efficiently for rapidly metabolic analysis.…”