Polymer hydrogel capsules: en route toward synthetic cellular systems

Städler, Brigitte; Price, Andrew D.F.; Chandrawati, Rona; Hosta‐Rigau, Leticia; Zelikin, Alexander N.; Caruso, Frank

doi:10.1039/b9nr00143c

Cited by 170 publications

(170 citation statements)

References 77 publications

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“…It was assumed from this that tri-n-butylborane is preferably incorporated into lipid bilayers. This finding suggested that tri-n-butylborane may be applicable for developing the colloidal initiator [47] and capsule liposome systems [49] Currently, borane derivatives have been used to develop an attractive new procedure for the reduction of radicals with alcohol and water.…”

Section: Polymerization With Low Surface-energy Plasticsmentioning

confidence: 99%

Tri-n-Butylborane/WaterComplex-Mediated Copolymerization of Methyl Methacrylate with Proteinaceous Materials and Proteins: A Review

Fujisawa

Kadoma

2010

Polymers

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Previous studies of tri-n-butylborane-initiated graft copolymerization of methyl methacrylates with hydrated proteinous materials and proteins have focused on the number of grafted-poly (MMA) branches as well as the percent graft and graft efficiency. The number of branches in silk fibroin is 1.3, whereas the number in collagen, gelatin, ovalbumin and wool are 0.1, 0.04, 0.02 and 0.03, respectively. The number of grafted-PMMA branches in synthetic poly-L-peptides is approximately 10-fold less than that in gelatin, and decline, in the order poly-Ala > poly-Ser > poly-Pro > poly-Glu > poly-Lys. By contrast, poly-Gly, poly-Tyr and poly-Leu have no branches. The co-catalytic effect (the ratio of the number of polymer formed relative to that of control) of amino acids on tri-n-butylborane-initiated polymerization of MMA in the presence of water has been linearly correlated with their ionization potential (IP koopman ); |Äå HOMO (Highest Occupied Molecular Orbital)| (r 2 = 0.6, outliers: Cys and His); Äå HOMO = [åHOMO aqua − åHOMO vacuum ] calculated using the semiempirical AM1 method. Also, a significant exponential relationship between the number of branches of poly-L-polypeptides and the Äå HOMO of the corresponding amino acids has been observed (r 2 = 0.9). A possible grafting site of protein (polypeptide) is discussed.

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Section: Polymerization With Low Surface-energy Plasticsmentioning

confidence: 99%

Tri-n-Butylborane/WaterComplex-Mediated Copolymerization of Methyl Methacrylate with Proteinaceous Materials and Proteins: A Review

Fujisawa

Kadoma

2010

Polymers

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“…In addition to their application as drug delivery vehicles [1,2], they are also employed in biosensing as labels [3] or as carriers for membrane proteins [4]. Further, they have recently been considered as sub-compartments in polymer capsules towards therapeutic cell mimicry [5][6][7] or as potential drug deposits embedded in polymer films on surfaces [8,9].…”

Section: Introductionmentioning

confidence: 99%

Myoblast Cell Interaction with Polydopamine Coated Liposomes

et al. 2012

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Liposomes are widely used, from biosensing to drug delivery. Their coating with polymers for stability and functionalization purposes further broadens their set of relevant properties. Poly(dopamine) (PDA), a eumelanin-like material deposited via the “self”-oxidative polymerization of dopamine at mildly basic pH, has attracted considerable interest in the past few years due to its simplicity, flexibility yet fascinating properties. Herein, we characterize the coating of different types of liposomes with PDA depending on the presence of oleoyldopamine in the lipid bilayer and the dopamine hydrochloride concentration. Further, the interaction of these coated liposomes in comparison to their uncoated counterparts with myoblast cells is assessed. Their uptake/association efficiency with these cells is determined. Further, their dose-dependent cytotoxicity with and without entrapped hydrophobic cargo (thiocoraline) is characterized. Taken together, the reported results demonstrate the potential of PDA coated liposomes as a tool in biomedical applications. Supplementary Material 13758_2011_8_MOESM1_ESM.doc (83KB)

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“…Polymeric drug vehicles such as nanoparticles, micelles, nanogels, micro/nano capsules are very advantageous in the control of drug distribution in the living organism, prolonging the biological activity of drugs, improving the therapeutic effect and reducing the administration frequency [6][7][8][9][10]. It is revealed that capsule-like drug carriers could easily realize high drug payload and achieve a better sustained release behavior due to their larger inner cavities [11][12][13][14], hence many efforts have been devoted to the synthesis of polymeric capsules. Layer-by-Layer (LbL) assembly is a widely used route to the preparation of polymeric capsules with well-defined chemical and structural properties, which potentially afford a large degree of control over functional properties of polyelectrolyte containers, such as their permeability to low molecular weight compounds or macromolecules [15,16].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

Nan

Chen

et al. 2014

Nano-Micro Lett

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Abstract:Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly (acrylic acid)-poly (N-isopropylacrylamide) (PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly (acrylic acid) (HPC-PAA) complexes as the templates. The capsules showed a high drug loading (∼280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and pH of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.

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Polymer hydrogel capsules: en route toward synthetic cellular systems

Cited by 170 publications

References 77 publications

Tri-n-Butylborane/WaterComplex-Mediated Copolymerization of Methyl Methacrylate with Proteinaceous Materials and Proteins: A Review

Tri-n-Butylborane/WaterComplex-Mediated Copolymerization of Methyl Methacrylate with Proteinaceous Materials and Proteins: A Review

Myoblast Cell Interaction with Polydopamine Coated Liposomes

Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

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