Polymer brush grafted antimicrobial peptide on hydroxyapatite nanorods for highly effective antibacterial performance

Li, Kai; Yang, Xue; Ding, Tiexin; Zhu, Shengbo; Mao, Mengting; Zhang, Lan; Han, Yong

doi:10.1016/j.cej.2021.130133

Cited by 53 publications

(34 citation statements)

References 65 publications

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“…However, this may fuel the growth of multi-drugresistant bacteria, causing uninhibited infections which may rapidly spread throughout the body, leading to the death of the patient. [10][11][12] This is avoidable if the surface of implanted biomaterials can be pretreated with antibacterials which are non-leachable so that they do not contaminate the environment with leached biocides, thus suppressing the chance of infections caused by antibiotic-resistant bacteria on the implants' surface. Moreover, because of their strong binding to the surface, non-leachable antibacterials would provide long-term protection to the surfaces against several pathogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…However, all these studies lack a cytocompatible surface which can not only allow healthy cells to grow, but also completely suppress the bacterial growth without the actual need to incorporate any additional antibiotics, thus mitigating the problem caused by evolutionary change in pathogens. Herein, we have designed and developed an innovative infection-resistant surface which will be composed of a copolymeric brush of zwitterionic polymer (antibacterial 10 and cytocompatible) and a hydrophilic non-ionic polymer with a long PEG ( polyethylene glycol) chain (antiadhesive 25 ) to provide a soft surface with strong antibacterial efficacy. With the help of a nanoindentation study, we were able to determine the composition of a soft brush required to completely reduce bacterial adhesion without compromising the growth of healthy cells.…”

Section: Introductionmentioning

confidence: 99%

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Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections

et al. 2022

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“…Direct incorporation of antimicrobial compounds affects the release rate and durability [100]. Li reported that covalent bonding between the antimicrobial peptide and packaging matrix helps to counterblast the release but has a negative impact on the stability of the antimicrobial activity's efficiency [101].…”

Section: Challenges In Incorporation Of Amp Into Food Packaging Materialsmentioning

confidence: 99%

Harvesting of Antimicrobial Peptides from Insect (Hermetia illucens) and Its Applications in the Food Packaging

2021

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About one-third of the total food produced is wasted, rising the concern to adopt proper management. Simultaneously with the increase in population, demand for food is increasing which may lead to scarcity. Adequate packaging is one of the ways to avoid deterioration of food and prevent wastage. In recent years, active packaging has attained interest due to its commendable results in food preservation. Several studies proved that the embodiment of antimicrobial components into the packaging material has the ability to prevent microbial contamination. Antimicrobial peptides (AMP) are newly discovered antimicrobial agents for impregnation into packaging material. Among various sources for AMP, insects have shown great resistivity against a wide spectrum of microorganisms. Insects feed on substances consisting of a varying range of contaminations, which often results in infections. Insects synthesise AMPs to fight such infections and survive in that atmosphere. The disease-causing agents in humans are the same as those found in insects. Hence, AMPs extracted from insects have the potential to fight the microorganisms that act as hazards to human health. This review highlights the harvesting and synthesis of AMPs from Hermetia illucens, which is a promising source for AMP and its applications in the food packaging industry.

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“…Hydroxyapatite (HAp) substitutions have the ability to induce both positive and negative effects on cell viability but also on the mechanical properties and solubility of biomaterials [ 1 , 2 , 3 , 4 ]. Synthetic equivalents of HAp have high biocompatibility and are commonly employed in clinical practice [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Nature-Inspired Effects of Naturally Occurring Trace Element-Doped Hydroxyapatite Combined with Surface Interactions of Mineral-Apatite Single Crystals on Human Fibroblast Behavior

Tyszka-Czochara

Suder

Dołhańczuk-Śródka

et al. 2022

IJMS

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Innovative engineering design for biologically active hydroxyapatites requires enhancing both mechanical and physical properties, along with biocompatibility, by doping with appropriate chemical elements. Herein, the purpose of this investigation was to evaluate and elucidate the model of naturally occurring hydroxyapatite and the effects of doped trace elements on the function of normal human fibroblasts, representing the main cells of connective tissues. The substrates applied (geological apatites with hexagonal prismatic crystal habit originated from Slyudyanka, Lake Baikal, Russia (GAp) and from Imilchil, The Atlas Mountains, Morocco (YAp)) were prepared from mineral natural apatite with a chemical composition consistent with the building blocks of enamel and enriched with a significant F− content. Materials in the form of powders, extracts and single-crystal plates have been investigated. Moreover, the effects on the function of fibroblasts cultured on the analyzed surfaces in the form of changes in metabolic activity, proliferation and cell morphology were evaluated. Apatite plates were also evaluated for cytotoxicity and immune cell activation capacity. The results suggest that a moderate amount of F− has a positive effect on cell proliferation, whereas an inhibitory effect was attributed to the Cl− concentration. It was found that for (100) GAp plate, fibroblast proliferation was significantly increased, whereas for (001) YAp plate, it was significantly reduced, with no cytotoxic effect and no immune response from macrophages exposed to these materials. The study of the interaction of fibroblasts with apatite crystal surfaces provides a characterization relevant to medical applications and may contribute to the design of biomaterials suitable for medical applications and the evaluation of their bioavailability.

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Polymer brush grafted antimicrobial peptide on hydroxyapatite nanorods for highly effective antibacterial performance

Cited by 53 publications

References 65 publications

Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections

Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections

Harvesting of Antimicrobial Peptides from Insect (Hermetia illucens) and Its Applications in the Food Packaging

Nature-Inspired Effects of Naturally Occurring Trace Element-Doped Hydroxyapatite Combined with Surface Interactions of Mineral-Apatite Single Crystals on Human Fibroblast Behavior

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