Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections

Abstract

Biomedical device or implant associated infections caused by pathogenic bacteria are one of the major leading clinical issues, prevention and/or treatment of which still remain a challenging task. Infection resistant...

Photoinduced micropatterning on biodegradable aliphatic polyester surfaces for anchoring dual brushes and its application in bacteria and cell patterning

“…93 Similar findings related to enhanced cell adhesion on thicker brushes were reported by others too. 94 (5) As reported in our previous study 95 (Table S4 of ref. 95, ESI †), the polyPEGMA brush modified surface exhibited lower hardness and reduced modulus as compared to the polyDMAPS brush modified surface.…”

“…94 (5) As reported in our previous study 95 (Table S4 of ref. 95, ESI †), the polyPEGMA brush modified surface exhibited lower hardness and reduced modulus as compared to the polyDMAPS brush modified surface. This may further facilitate cell adhesion on a relatively hard surface, i.e., the polyDMAPS region.…”

“…19,30 via surface aminolysis which causes significant degradation of polymeric backbones as revealed from their reduced molecular weight after the aminolysis step. In contrast to this, the methodology used in this study and our previous publications as well 18,19,31 doesn’t suffer from significant loss of molecular weight of the substrate post immobilization of the ATRP initiating moiety. Thus, grafting of polymer brushes in a designated domain to construct a micropatterned surface using spatio-selective chemistry, e.g.…”

Recent nanotechnology-based strategies for interfering with the life cycle of bacterial biofilms

“…On the other hand, there are some studies indicating that hydrogen bonding with hydrophilic surfaces can also help bacterial adhesion. 45 Consequently, surfaces with moderate wettability allow bacterial adhesion through hydrogen bonding or hydrophobic interactions, [47][48][49] which depends on not only the surface wettability but also the bacterial species. 50,51 However, superwettable surfaces can resist bacterial adhesion through the formation of natural barriers.…”

Recent Advance in Polymer Coatings Combating Bacterial Adhesion and Biofilm Formation†

“…developed a robust antifouling coating prepared from bovine serum albumin (BSA, Figure 3b). [ 64 ] By reducing the intramolecular disulfide bonds, BSA can undergo a phase transition in aqueous solution and supramolecular assembly forming a dense nanofilm (phase‐transited BSA, PTB) that can coat on many material surfaces, such as glass, metals, and plastics. The PTB coating showed excellent resistance to various protein adsorptions (as low as 0.2 ng/cm 2 ).…”