Polymer-based bionanomaterials for targeted drug delivery

Mahendiran, Balaji; Nazeer, Abdul Azeez; Muthusamy, Shalini; Krishnakumar, Gopal Shankar

doi:10.1016/b978-0-12-824147-9.00009-1

Cited by 4 publications

(2 citation statements)

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“…The nano-bio interaction, biological fate, and targeting capacity of NPs are also dependent on the parameters of functionalization which is adding or improvement of physio-chemical properties either by addition or conjugation of biomolecules, reduction, or stabilization with different materials [ 12 , 280 ]. Surface chemistry, chemical groups, or chemical composition can highly influence the antimicrobial activities, biological uptake, and cytotoxicity of NPs [ 12 , 13 ].…”

Section: Factors Affecting Properties and Applicationsmentioning

confidence: 99%

Therapeutic applications of nanobiotechnology

et al. 2023

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Nanobiotechnology, as a novel and more specialized branch of science, has provided a number of nanostructures such as nanoparticles, by utilizing the methods, techniques, and protocols of other branches of science. Due to the unique features and physiobiological characteristics, these nanostructures or nanocarriers have provided vast methods and therapeutic techniques, against microbial infections and cancers and for tissue regeneration, tissue engineering, and immunotherapies, and for gene therapies, through drug delivery systems. However, reduced carrying capacity, abrupt and non-targeted delivery, and solubility of therapeutic agents, can affect the therapeutic applications of these biotechnological products. In this article, we explored and discussed the prominent nanobiotechnological methods and products such as nanocarriers, highlighted the features and challenges associated with these products, and attempted to conclude if available nanostructures offer any scope of improvement or enhancement. We aimed to identify and emphasize the nanobiotechnological methods and products, with greater prospect and capacity for therapeutic improvements and enhancements. We found that novel nanocarriers and nanostructures, such as nanocomposites, micelles, hydrogels, microneedles, and artificial cells, can address the associated challenges and inherited drawbacks, with help of conjugations, sustained and stimuli-responsive release, ligand binding, and targeted delivery. We recommend that nanobiotechnology, despite having few challenges and drawbacks, offers immense opportunities that can be harnessed in delivering quality therapeutics with precision and prediction. We also recommend that, by exploring the branched domains more rigorously, bottlenecks and obstacles can also be addressed and resolved in return. Graphical Abstract

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Section: Factors Affecting Properties and Applicationsmentioning

confidence: 99%

Therapeutic applications of nanobiotechnology

et al. 2023

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“…The process of adding new functional groups to the surface of the materials via chemical or physical interaction is called functionalization [ 183 , 184 ]. DESs have been recognized as functionalization agents for nanomaterial engineering.…”

Section: Design Strategy and Application Of Des For Nanomaterials Fab...mentioning

confidence: 99%

Design Strategy and Application of Deep Eutectic Solvents for Green Synthesis of Nanomaterials

et al. 2023

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The first report of deep eutectic solvents (DESs) was released in 2003 and was identified as a new member of ionic liquid (IL), involving innovative chemical and physical characteristics. Using green solvent technology concerning economical, practical, and environmental aspects, DESs open the window for sustainable development of nanomaterial fabrication. The DESs assist in different fabrication processes and design nanostructures with specific morphology and properties by tunable reaction conditions. Using DESs in synthesis reactions can reduce the required high temperature and pressure conditions for decreasing energy consumption and the risk of environmental contamination. This review paper provides the recent applications and advances in the design strategy of DESs for the green synthesis of nanomaterials. The strategy and application of DESs in wet-chemical processes, nanosize reticular material fabrication, electrodeposition/electrochemical synthesis of nanostructures, electroless deposition, DESs based nano-catalytic and nanofluidic systems are discussed and highlighted in this review.

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