Polyimide cuff electrodes for peripheral nerve stimulation

Rodríguez, Francisco; Ceballos, Dolores; Schüttler, Martin; Valero, Antoni; Valderrama, Elena; Stieglitz, Thomas; Navarro, Xavier

doi:10.1016/s0165-0270(00)00192-8

Cited by 192 publications

(122 citation statements)

References 28 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…Specifically, the sciatic nerve is the peripheral nerve of choice when conducting animal studies involving nerve gap repair or peripheral nerve electrode implantation. With regard to electrode implantation, the rat sciatic nerve has been used extensively in experiments with nerve cuff (Jellema and Teepen, 1995;Rodrıguez et al, 2000;Vince et al, 2004;Vince et al, 2005a,b) and sieve or regenerating electrodes (Klinge et al, 2001;Ceballos et al, 2002;Lago et al, 2005;Castro et al, 2008;Kim et al, 2009;Lacour et al, 2009), whereas the cat sciatic nerve is also commonly used in nerve cuff electrode studies (Stein et al, 1977;Hoffer et al, 1981;Krarup and Loeb, 1988;Walter et al, 1995;Loeb and Peck, 1996;Grill and Mortimer, 2000;Romero et al, 2001) and has been used more frequently for experiments using penetrating peripheral nerve devices (Branner et al, 2001(Branner et al, , 2004Leventhal et al, 2006). To understand the changes that might occur in the underlying nerve after the implantation of these peripheral nerve devices, it is necessary to have knowledge of the basic structure and composition of the nerve under normal conditions.…”

mentioning

confidence: 99%

“…The composition of the rat sciatic nerve has been relatively well studied and morphometric parameters for myelinated fibers, such as fascicle area (Podhajsky and Myers, 1993;Di Benedetto et al, 1998), fiber count (Jenq and Coggeshall, 1985a,b;Jenq et al, 1986;Schmalbruch, 1986;Rodrıguez et al, 2000;Ceballos et al, 2002;Rafiuddin Ahmed and Jayakumar, 2003;Lago et al, 2005Lago et al, , 2007Prodanov and Feirabend, 2007), fiber density (number of myelinated fibers per fascicle unit area) (De Angelis et al, 1994;Rodrıguez et al, 2000;Mazzer et al, 2008), fiber packing (the percent of the fascicular area occupied by myelinated fibers) (Koller et al, 1992), mean fiber diameter (Le Beau et al, 1988;Koller et al, 1992;De Angelis et al, 1994;Di Benedetto et al, 1998;Prodanov and Feirabend, 2007), fiber diameter distributions (Strain and Olson, 1975;Schmalbruch, 1986;Wehling et al, 1992;Rodrıguez et al, 2000;Prodanov and Feirabend, 2007;Mazzer et al, 2008), and mean g-ratio (Adhami et al, 1976;De Angelis et al, 1994;Di Benedetto et al, 1998;Rodrıguez et al, 2000;Rafiuddin Ahmed and Jayakumar, 2003;Mazzer et al, 2008) or g-ratio distributions (Mazzer et al, 2008), have been described (Table 1). It is important to recognize that such data have been collected from multiple strains and from rats of varying ages, variables whose influence on morphometric parameters have not been exami...…”

mentioning

confidence: 99%

See 1 more Smart Citation

Differences Exist in the Left and Right Sciatic Nerves of Naïve Rats and Cats

Christensen

Tresco

2015

The Anatomical Record

View full text Add to dashboard Cite

The sciatic nerve of rats and cats is commonly used in experimental models of peripheral nerve injury and repair, as well as experiments involving peripheral nerve electrode implantation. In such experiments, morphometric parameters from the implanted nerve are commonly evaluated and compared to control values obtained from the contralateral nerves. However, this may not be an appropriate approach as differences may naturally exist in the structure of the two nerves owing to developmental or behavioral asymmetry. Additionally, in the cat, baseline values for standard morphometric parameters are not well established. In this study, we characterized fascicle area, fiber count, fiber density, fiber packing, mean g-ratio, and fiber diameter distributions in the rat and cat, as well as investigated the potential for naturally occurring sided differences in these parameters in both species. We also investigated whether animal age or location along the nerve influenced these parameters. We found that sided or left/right leg differences exist in some parameters in both the rat and the cat, calling into question the validity of using the contralateral nerve as a control. We also found that animal age and location along the nerve can make significant differences in the parameters tested, establishing the importance of using control nerves from age-and behaviorally matched animals whose morphometric parameters are collected and compared from the same location. Anat Rec, 298:1492Rec, 298: -1501Rec, 298: , 2015. V C 2015 Wiley Periodicals, Inc.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Differences Exist in the Left and Right Sciatic Nerves of Naïve Rats and Cats

Christensen

Tresco

2015

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…Hybrid polyimide cuff electrodes embedded in silicone guidance channels have been fabricated for electrical stimulation of peripheral nerves (Stieglitz et al (2005)). Polyimide sieve electrodes have been used in the regeneration and functional re-innervation of sensory and motor nerve fibers (Rodríguez et al (2000)). Rubehn et al (2009) reported the fabrication of a micro-machined 252-channel ECoG (electrocorticogram)-electrode array made of a thin polyimide foil substrate enclosing sputtered platinum electrode sites and conductor paths.…”

Section: Flexible Substratesmentioning

confidence: 99%

New Trends and Challenges in the Development of Microfabricated Probes for Recording and Stimulating of Excitable Cells

Braeken¹,

Prodanov²

2010

New Developments in Biomedical Engineering

View full text Add to dashboard Cite

types of neural prostheses are unclear. Notable exceptions for this are the auditory cochlear prostheses, which exploit the sonotopic organization of the cochlea, the cardiac pacemakers, the phrenic stimulator and the foot drop stimulator. Current DBS systems for Parkinson's disease rely on the high frequency stimulation, which can result in blocking of certain mid-brain pathways. The encoding of the kinematic information in these structures is still unknown. Dissociated cell cultures lose their anatomical connectivity and structure when seeded on substrates in vitro. The 'new' situation that exists on these surfaces is interesting in terms of communication between individual cells and their function in advanced networks. However, the translation of these processes to the in vivo situation is not always straightforward and challenging. On the level of the overall device several types of issues can be grouped in the categories of configuration and operation. Issues related to the configuration can be related to the assembly, the size and topology of the device, the encapsulation and the packaging of the device. Devices have to be packaged in a way that prevents leakage of the environment, which contains high salt and protein concentrations, to the chip. These packages have to be leakage-proof on the one hand and non-toxic for the cell culture or tissue on the other hand. Issues related to the operation of the device can be grouped under the power, safety and communication of the device. The operation has to be compatible with cell cultures or in vivo environments, which in this case has to be in agreement with certain regulations. One other important aspect of the safety of operation are the interactions with other equipment, for example MRI.

show abstract

“…Several kinds of flexible sensors have been developed for bioapplications, [1][2][3][4][5][6] with parylene or poly(dimethylsiloxane) (PDMS) most commonly being used as the flexible substrate. For highly sensitive comprehensive assays, a CMOS-based sensor and an electrode array device have been fabricated on flexible substrates.…”

Section: Introductionmentioning

confidence: 99%

SU-8-based Flexible Amperometric Device with IDA Electrodes to Regenerate Redox Species in Small Spaces

et al. 2014

View full text Add to dashboard Cite

A flexible sensor based on SU-8 photoresist was fabricated and its electrochemical performance was investigated using cyclic voltammetry. The device consisted of interdigitated array (IDA) electrodes on an SU-8 layer. It exhibited a clear electrochemical response during redox cycling of ferrocenemethanol at the IDA electrodes. Since the device was flexible, it could be inserted into a narrow bent space to monitor electrochemical responses. The observed electrochemical behavior was found to be consistent with that predicted by simulations based on redox compound diffusion.

show abstract

Polyimide cuff electrodes for peripheral nerve stimulation

Cited by 192 publications

References 28 publications

Differences Exist in the Left and Right Sciatic Nerves of Naïve Rats and Cats

Differences Exist in the Left and Right Sciatic Nerves of Naïve Rats and Cats

New Trends and Challenges in the Development of Microfabricated Probes for Recording and Stimulating of Excitable Cells

SU-8-based Flexible Amperometric Device with IDA Electrodes to Regenerate Redox Species in Small Spaces

Contact Info

Product

Resources

About