Polyhydroxy Amino Acid Derivatives via β-Lactams Using Enantiospecific Approaches and Microwave Techniques

Cycloaddition of optically active and racemic imines with diverse acid chlorides in the presence of a tertiary amine has been studied extensively for the synthesis of beta lactams. The conditions of the experiments have profound influence on the course of the reaction and stereochemistry of the products. Numerous methods are adopted for this cycloaddition reaction in order to control the yields, stereochemistry of the products, and durations of the reactions. This perspective demonstrates a few methods that are used for the synthesis of numerous beta lactams by cycloaddition reaction of imines and acid chlorides in the presence of a tertiary amine. The beta lactams are one of the most challenging heterocyclic compounds discovered in the world.

Section: Methods 4: Microwave-induced Methodsmentioning

confidence: 99%

Cycloaddition Reaction of Imines with Acid Chlorides in the Presence of a Tertiary Base: Variation of the Methods for the Synthesis of Beta Lactams

Banik¹

2017

“…There was an inversion of configuration of the stereochemistry of the ring system during mesylate displacement reaction by azide [7].…”

Section: Hydroxy β-Lactams To Amino β-Lactamsmentioning

confidence: 99%

“…Deprotection of a relatively unstable ketal or sugar group in a β-lactam with iodine to a diol, oxidation of the diol with ruthenium trichloride/sodium periodate to an acid and esterification of the acid with diazomethane to an ester was conducted following onepot method [7]. The yield of the ester was high.…”

Section: Deprotection Oxidation and Esterification In β-Lactamsmentioning

confidence: 99%

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One-Pot Reactions: Expeditious Synthesis of Diverse Organic Compounds of Current Interests

Banik¹

2017

Organic compounds are in general synthesized by multiple steps and as a result, isolation and purification of the compounds after each step is necessary. Therefore, synthesis of unknown organic molecules becomes expensive and the whole process becomes time-consuming. To design reactions that can be done in a one-pot method is necessary. In continuation of our studies on antibiotics, anticancer agents and diverse heterocycles, this perspective demonstrates a few one-pot methods for the synthesis of numerous compounds of current interests.

“…Protection and deprotection reactions with molecular iodine were used in beta-lactam chemistry. These methods were necessary for preparation of amino sugars, amino acids, alkaloids and polycyclic beta-lactams [3].…”

Section: Protection and Deprotection Of Carbonyl Compoundsmentioning

confidence: 99%

Molecular Iodine-Catalyzed Reactions: Our Own Account

Banik¹

2017