Cycloaddition Reaction of Imines with Acid Chlorides in the Presence of a Tertiary Base: Variation of the Methods for the Synthesis of Beta Lactams

Abstract

Cycloaddition of optically active and racemic imines with diverse acid chlorides in the presence of a tertiary amine has been studied extensively for the synthesis of beta lactams. The conditions of the experiments have profound influence on the course of the reaction and stereochemistry of the products. Numerous methods are adopted for this cycloaddition reaction in order to control the yields, stereochemistry of the products, and durations of the reactions. This perspective demonstrates a few methods that are used for the synthesis of numerous beta lactams by cycloaddition reaction of imines and acid chlorides in the presence of a tertiary amine. The beta lactams are one of the most challenging heterocyclic compounds discovered in the world.