heterocyclic 4-membered rings heterocyclic 4-membered rings R 0055 47 -103 Studies in Lactams. Part 108. Microwave-Induced Organic Reactions Enhancement (MORE) Chemistry. Part 15. Polyhydroxy Amino Acid Derivatives via β-Lactams Using Enantiospecific Approaches and Microwave Techniques.-Coupling of acid chlorides of type (II) with Schiff bases derived from carbohydrates allows stereospecific synthesis of β-lactams. Conventional as well as microwave-assisted reactions can be used successfully. The latter are rapid, safe, environment friendly, and show high levels of atom economy. The β-lactams can be converted into polyhydroxy amino acid derivatives like (VI) and (XV) as well as intermediates of 6-epilincosamine and gentosamine [see (X) and (XVII)]. -(BOSE, AJAY K.; BANIK, BIMAL K.; MATHUR, CHANDRA; WAGLE, DILIP R.; MANHAS, MAGHAR S.; Tetrahedron 56 (2000) 31, 5603-5619; M. D. Anderson Cancer Cent., Univ. Tex., Houston, TX 77030, USA; EN)
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