Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis

Vitt, Anton; Gustafsson, Anders; Ramberg, Per; Slizen, Veronica; Казеко, Л. А.; Buhlin, Kåre

doi:10.1080/00016357.2018.1541099

Cited by 12 publications

(11 citation statements)

References 33 publications

(33 reference statements)

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“…Irrigation can easily eliminate the bacteria and its by-products from the periodontal pockets by constant water pressure on the tissue created by compressive force [10]. Several clinical studies have reported on the use of 0.6% triclosan, 1% polyhexamethylene guanidine phosphate, 10% povidone-iodine, 0.25% sodium hypochlorite, 0.75% boric acid, and 20 mg/mL concentration of ozonated water as irrigations [11][12][13][14][15][16][17][18][19]. The outcomes of the above studies were determined based on significant reduction in plaque index (PI), bleeding index (BI), periodontal pocket depth (PPD) scores, and clinical attachment level (CAL) gain.…”

Section: Irrigation Devices/systemsmentioning

confidence: 99%

“…The outcomes of the above studies were determined based on significant reduction in plaque index (PI), bleeding index (BI), periodontal pocket depth (PPD) scores, and clinical attachment level (CAL) gain. These irrigating agents, when used as an adjunct to SRP showed comparatively better therapeutic outcomes than in the control groups [11][12][13][14][15][16][17][18][19]. In general, it was found that the irrigating systems significantly showed good results but in the short-term since they have had a transient action.…”

Section: Irrigation Devices/systemsmentioning

confidence: 99%

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Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

et al. 2020

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This review sheds light on the recent published scientific evidence relating to the use of professionally delivered local antimicrobial agents (LA’s). The review also analyses drug delivery systems available to date and provides an update on the latest scientific evidence about the benefits, limitations, and clinical results obtained by use of local drugs in the treatment of periodontal disease. The search strategy revealed randomized controlled trials (RCTs) that compared the efficacy of adjunctive LA’s to mechanical therapy alone. Based on the available evidence gathered from this review, we can infer that the use of local antimicrobial agents in conjunction to scaling and root debridement (SRD) delivers significant benefits in periodontal therapy and it is a useful aid, avoiding many of the side effects that systemic antibiotic therapy may involve. Local drug delivery (LDD) is an efficient and effective means of delivering drugs based on the evidence presented in the review. The authors of this review would suggest the use of local antimicrobials in cases of localized periodontitis or individual areas that do not respond to the usual mechanical therapy alone. This review summarizes the current use of local drug delivery in periodontal management ensuring that the general practitioners are able to choose an appropriate local antimicrobial.

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Section: Irrigation Devices/systemsmentioning

confidence: 99%

Section: Irrigation Devices/systemsmentioning

confidence: 99%

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

et al. 2020

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“…The reasons for excluding studies after full-text assessment were as follows: a follow-up time < 6 months (n = 7) [33][34][35][36][37][38][39], antiseptics applied to periodontal pockets prior to periodontal treatment (n = 1) [40], antiseptics applied continuously to worsening sites after an initial periodontal treatment (n = 3) [41][42][43], repeated periodontal treatment and antiseptics applied at all followup visits (n = 1) [44], and periodontal treatment established only by ultrasonic instruments (n = 3) [45][46][47].…”

Section: Study Exclusionmentioning

confidence: 99%

Antiseptics as adjuncts to scaling and root planing in the treatment of periodontitis: a systematic literature review

Ramanauskaitė

Mačhiulskienė

2020

BMC Oral Health

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Background: Periodontitis is microbially-associated, host-mediated inflammatory condition that results in loss of periodontal attachment. The goals of periodontal therapy include arresting the disease progression, establishing healthy, stable, maintainable periodontal conditions. A fundamental strategy of treating periodontitis is scaling and root planning (SRP), however its efficacy may be restricted in areas inaccessible for mechanical instrumentation. As periodontitis is infectious in nature, it might be helpful to use additional antimicrobial adjuncts, in order to eliminate or inactivate pathogenic microflora. The aim of this study is to evaluate the current evidence regarding the potential clinical benefits of using additional antiseptics for SRP in nonsurgical periodontal therapy. Methods: An electronic literature search was conducted in the MEDLINE (Ovid) and Cohrane Central Register of Controlled Trials (CENTRAL) databases for articles published between January 1, 2000 and September 22, 2019. Randomized controlled clinical trials in English that compare the effectiveness of one or more antiseptic agents as adjuncts to SRP with a follow-up of ≥6 months were included. A meta-analysis using the random-effects model was performed on the selected qualifying articles. Results: The search resulted in 12 articles that met the inclusion criteria. Based on the vehicle employed to deliver the antiseptic agent, studies were divided into adjunctive sustained-release antiseptics (gels, chips and varnish) and adjunctive irrigation with antiseptics. The meta-analysis demonstrated significant improvements in probing depth (PD) reduction (p = 0.001), clinical attachment level (CAL) gain (p = 0.001), and bleeding on probing (BOP) values (p = 0.001) following the adjunctive subgingival application of sustained-release antiseptics. Additional subgingival irrigation with antiseptics failed to show significant improvements in PD (p = 0.321), CAL (p = 0.7568), or BOP values (p = 0.3549) over SRP alone. Conclusions: Adjunctive subgingivally delivered antiseptics with a sustained-release delivery have significant clinical benefits compared to SRP alone.

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“…The reasons for excluding studies after full-text assessment were as follows: a follow-up time <6 months (n = 7) [24][25][26][27][28][29][30], antiseptics applied to periodontal pockets prior to periodontal treatment (n = 1) [31], antiseptics applied continuously to worsening sites after an initial periodontal treatment (n = 3) [32][33][34], repeated periodontal treatment and antiseptics applied at all follow-up visits (n = 1) [35], and periodontal treatment established only by ultrasonic instruments (n = 3) [36][37][38].…”

Section: Study Exclusionmentioning

confidence: 99%

Antiseptics as Adjuncts to Scaling and Root Planing in the Treatment of Periodontitis: A Systematic Literature Review

Ramanauskaitė

Mačhiulskienė

2019

Preprint

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Background: Periodontitis is microbially-associated, host-mediated inflammatory condition that results in loss of periodontal attachment. The goals of periodontal therapy include arresting the disease progression, establishing healthy, stable, maintainable periodontal conditions. A fundamental strategy of treating periodontitis is scaling and root planing (SRP), however its efficacy may be restricted in areas inaccessible for mechanical instrumentation. As periodontitis is infectious in nature, it might be helpful to use additional antimicrobial adjuncts, in order to eliminate or inactivate pathogenic microflora. The aim of this study is to evaluate the current evidence regarding the potential clinical benefits of using additional antiseptics for SRP in nonsurgical periodontal therapy. Methods: An electronic literature search was conducted in the MEDLINE (Ovid) and Cohrane Central Register of Controlled Trials (CENTRAL) databases for articles published between January 1, 2000 and September 22, 2019. Randomized controlled clinical trials in English that compare the effectiveness of one or more antiseptic agents as adjuncts to SRP with a follow-up of ≥ 6 months were included. A meta-analysis using the random-effects model was performed on the selected qualifying articles. Results: The search resulted in 12 articles that met the inclusion criteria. Based on the vehicle employed to deliver the antiseptic agent, studies were divided into adjunctive sustained-release antiseptics (gels, chips and varnish) and adjunctive irrigation with antiseptics. The meta-analysis demonstrated significant improvements in probing depth (PD) reduction (p = 0.001), clinical attachment level (CAL) gain (p = 0.001), and bleeding on probing (BOP) values (p = 0.001) following the adjunctive subgingival application of sustained-release antiseptics. Additional subgingival irrigation with antiseptics failed to show significant improvements in PD (p = 0.321), CAL (p = 0.7568), or BOP values (p = 0.3549) over SRP alone. Conclusions: Adjunctive subgingivally delivered antiseptics with a sustained-release delivery have significant clinical benefits compared to SRP alone. Key Words: Periodontitis, Antiseptics, Treatment, Review

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Polyhexamethylene guanidine phosphate irrigation as an adjunctive to scaling and root planing in the treatment of chronic periodontitis

Cited by 12 publications

References 33 publications

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

Professionally Delivered Local Antimicrobials in the Treatment of Patients with Periodontitis—A Narrative Review

Antiseptics as adjuncts to scaling and root planing in the treatment of periodontitis: a systematic literature review

Antiseptics as Adjuncts to Scaling and Root Planing in the Treatment of Periodontitis: A Systematic Literature Review

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