Polyethyleneimine brushes effectively inhibit encrustation on polyurethane ureteral stents both in dynamic bioreactor and in vivo

Gultekinoglu, Merve; Kürüm, Barış; Karahan, Siyami; Kart, Didem; Sağıroğlu, Meral; Ertaş, Nusret; Ozen, A. Haluk; Ulubayram, Kezban

doi:10.1016/j.msec.2016.11.125

Cited by 38 publications

(30 citation statements)

References 35 publications

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“…This reactor enables the growth of bacterial biofilms on removable coupons under controlled conditions to evaluate the effects of bacterial species, modulators of struvite crystallization, and urine chemistry on biomineralization. Other systems have been developed to study the process of encrustation of different materials used in urinary tract devices (for example, silicon, polyurethane, and Percuflex) 190,191 . Hobbs et al 192 developed an in vitro system that simulates the urinary tract system using CDC biofilm reactors as kidney and bladder analogues, tubing to simulate the ureter line, and sponge coupons to simulate the porous structure of the kidneys.…”

Section: Multidisciplinary Approach To Managementmentioning

confidence: 99%

Current insights into the mechanisms and management of infection stones

et al. 2018

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Infection stones are complex aggregates of crystals amalgamated in an organic matrix that are strictly associated with urinary tract infections. The management of patients who form infection stones is challenging owing to the complexity of the calculi and high recurrence rates. The formation of infection stones is a multifactorial process that can be driven by urine chemistry , the urine microenvironment, the presence of modulator substances in urine, associations with bacteria, and the development of biofilms. Despite decades of investigation, the mechanisms of infection stone formation are still poorly understood. A mechanistic understanding of the formation and growth of infection stones-including the role of organics in the stone matrix, microorganisms, and biofilms in stone formation and their effect on stone characteristics-and the medical implications of these insights might be crucial for the development of improved treatments. Tools and approaches used in various disciplines (for example, engineering, chemistry , mineralogy , and microbiology) can be applied to further understand the microorganism-mineral interactions that lead to infection stone formation. Thus, the use of integrated multidisciplinary approaches is imperative to improve the diagnosis, prevention, and treatment of infection stones.

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Section: Multidisciplinary Approach To Managementmentioning

confidence: 99%

Current insights into the mechanisms and management of infection stones

et al. 2018

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“…Traditional ureteral stents are usually made by inert materials, e.g., stainless steel and polyurethane, which may cause long-term complications, such as infection, pain, hematuria and the formation of capsids and stones. A second surgery is usually used to remove the stent, which may bring not only physical and psychological pain, but also the postoperative secondary infection to patients [8] , [9] . Therefore, it is of great clinical value to explore biodegradable ureteral stents to avoid requiring subsequent operations.…”

Section: Introductionmentioning

confidence: 99%

Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models

Zhang

et al. 2017

Bioactive Materials

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In this work, the biodegradable and histocompatibility properties of pure Mg and ZK60 alloy were investigated as new temporary implants for urinary applications. The corrosion mechanism in artificial urine was proposed using electrochemical impedance spectroscopy and potentiodynamic polarization tests. The corrosion potential of pure magnesium and ZK60 alloy were −1820 and −1561 mV, respectively, and the corrosion current densities were 59.66 ± 6.41 and 41.94 ± 0.53 μA cm−2, respectively. The in vitro degradation rates for pure Mg and ZK60 alloy in artificial urine were 0.382 and 1.023 mm/y, respectively, determined from immersion tests. The ZK60 alloy degraded faster than the pure Mg in both artificial urine and in rat bladders (the implants of both samples are ø 3 mm × 5 mm). Histocompatibility evaluations showed good histocompatibility for the pure Mg and ZK60 alloy during the 3 weeks post-implantation in rat bladders, and no harm was observed in the bladder, liver and kidney tissues. The results provide key information on the degradation properties and corrosion mechanism of pure Mg and ZK60 alloy in the urinary system.

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“…54 Aguilar et al describe a thermoresponsive matrix incorporating nanofibres in PU for a non-vascular nitinol stent alternating that uses an alternating magnetic field for hyperthermia therapy; 55 5-fluorouracil and/or paclitaxel were simultaneously released. Polyethyleneimine (PEI) brushes have been grafted onto PU ureteral stents to help prevent host tissue inflammation and blockage; 56 further alkylation of the brushes led to enhanced antibacterial activity. PU stents are being used in infants and children with Kawasaki disease, a multisystem inflammatory disease that is the most common cause of acquired heart disease in children; 57 the thick (90 μm) PU membrane electrospun around an Orsiro stent had the most desirable stretching properties.…”

Section: Stentsmentioning

confidence: 99%

Biomedical applications of polyurethane materials and coatings

Joseph

Patel

Wenham

et al. 2018

Transactions of the IMF

131

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Polyurethanes (PUs), formed by the reaction of diisocyanates with polyols (or equivalent) in the presence of a catalyst, have a wide variety of industrial uses. Much recent attention has focused on their biomedical applications, owing to their biocompatibility, biodegradability and tailorable chemical and physical forms. Examples of such application areas include antibacterial surfaces and catheters, drug delivery vehicles, stents, surgical dressings/pressure sensitive adhesives, tissue engineering scaffolds and electrospinning, nerve generation, cardiac patches and PU coatings for breast implants. Following a brief introduction to PUs, this review surveys selected articles, mostly from 2014 to 2017, that highlight this diverse range of biomedical applications offered by PU materials and coatings.

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Polyethyleneimine brushes effectively inhibit encrustation on polyurethane ureteral stents both in dynamic bioreactor and in vivo

Cited by 38 publications

References 35 publications

Current insights into the mechanisms and management of infection stones

Current insights into the mechanisms and management of infection stones

Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models

Biomedical applications of polyurethane materials and coatings

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