Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models

Zhang, Shiying; Bi, Yanze; Li, Jianye; Wang, Zhenguo; Yan, Jingmin; Song, Jiawang; Huang, Sheng; Guo, Heqing; Li, Yan

doi:10.1016/j.bioactmat.2017.03.004

Cited by 45 publications

(35 citation statements)

References 44 publications

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“…Xu et al [ 39 ] reported that the corrosion rate of a cast ZK60 alloy decreased with the immersion time in solutions containing 3.5 wt.% NaCl, NaBr, and NaI, while it displayed passivation in 3.5 wt.% NaF solution. Apart from the above reports, some studies focused on the biodegradation behavior of ZK60 alloys in Hank’s solution, Ringer’s solution, simulated body fluid, and artificial urine for biomedical applications [ 40 , 41 , 42 , 43 ]. The biodegradable property of the ZK60 alloys is the interesting issue in these investigations.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and Corrosion of Cast Magnesium Alloy ZK60 in NaCl Solution

Peng

et al. 2020

Materials

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In this work, the effects of the microstructure and phase constitution of cast magnesium alloy ZK60 (Mg-5.8Zn-0.57Zr, element concentration in wt.%) on the corrosion behavior in aqueous NaCl (0.1 mol dm−3) were investigated by weight-loss measurements, hydrogen evolution tests, and electrochemical techniques. The alloy was found to be composed of α-Mg matrix, with large second-phase particles of MgZn2 deposited along grain boundaries and a Zr-rich region in the central area of the grains. The large second-phase particles and the Zr-rich regions were more stable than the Mg matrix, resulting in a strong micro-galvanic effect. A filiform corrosion was found. It originated from the second-phase particles in the grain boundary regions in the early corrosion period. The filaments gradually occupied most areas of the alloy surface, and the general corrosion rate decreased significantly. Corrosion pits were developed under filaments. The pit growth rate decreased over time; however, it was about eight times larger than the general corrosion rate. A schematic model is presented to illustrate the corrosion mechanism.

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Section: Introductionmentioning

confidence: 99%

Microstructure and Corrosion of Cast Magnesium Alloy ZK60 in NaCl Solution

Peng

et al. 2020

Materials

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“…One of the dominant hindrances for the commercial employment of Mg-based implant devices is ascribed to their rapid in vivo degradation process, which can deteriorate mechanical integrity significantly and reduce the desired lifespan to a great magnitude [3] , [4] . The degradation products, including insoluble metal oxide/phosphates, hydrogen gas, and soluble Mg 2+ and hydroxyl (OH − ) ions, can incur a number of detrimental reactions to the surrounding tissues and matrices [5] , [6] .…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of Mg-14Li alloy in simulated body fluid: A proof-of-concept study

Chen

2018

Bioactive Materials

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High corrosion kinetics and localised corrosion progress are the primary concerns arising from the clinical implementation of magnesium (Mg) based implantable devices. In this study, a binary Mg-lithium (Li) alloy consisting a record high Li content of 14% (in weight) was employed as model material aiming to yield homogenous and slow corrosion behaviour in a simulated body fluid, i.e. minimum essential medium (MEM), in comparison to that of generic Mg alloy AZ31 and biocompatible Mg-0.5Zn-0.5Ca counterparts. Scanning electron microscopy examination reveals single-phase microstructural characteristics of Mg-14Li (β-Li), whilst the presence of insoluble phases, cathodic to α-Mg matrix, in AZ31 and Mg-0.5Zn-0.5Ca. Though slight differences exist in the corrosion kinetics of all the specimens over a short-term time scale (no longer than 60 min), as indicated by potentiodynamic polarisation and electrochemical impedance spectroscopy, profound variations are apparent in terms of immersion tests, i.e. mass loss and hydrogen evolution measurements (up to 7 days). Cross-sectional micrographs unveil severe pitting corrosion in AZ31 and Mg-0.5Zn-0.5Ca, but not the case for Mg-14Li. X-ray diffraction patterns and X-ray photoelectron spectroscopy confirm that a compact film (25 μm in thickness) consisting of lithium carbonate (Li2CO3) and calcium hydroxide was generated on the surface of Mg-14Li in MEM, which contributes greatly to its low corrosion rate. It is proposed therefore that the single-phase structure and formation of protective and defect-free Li2CO3 film give rise to the controlled and homogenous corrosion behaviour of Mg-14Li in MEM, providing new insights for the exploration of biodegradable Mg materials.

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“…Secondly, they applied PLLA coating to the ZK60 (Mg, 4.8–6.2 wt.% Zn, 0.64 wt.% Zr, 0.012 wt.% Mn, 0.0021 wt.% Fe, 0.0016 wt.% Si, 0.0014 wt.% Al, 0.001 wt.% Cu) plate and used it in the LF I canine model of beagle dog [ 119 ]. Although ZK60 has stronger mechanical strength than WE43, it has the disadvantage of showing fast absorption [ 128 , 129 ] Accordingly, PLLA coating was applied to the plate to delay the absorption of plates and screws. However, because the PLLA coating was damaged throughout the bending process, it was not possible to prevent the rapid absorption of ZK60.…”

Section: New Bioabsorbable Plates and Screws—magnesium Plates And mentioning

confidence: 99%

Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials

Cho

Byun

et al. 2020

Biomedicines

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Clinical application of osteofixation materials is essential in performing maxillofacial surgeries requiring rigid fixation of bone such as trauma surgery, orthognathic surgery, and skeletal reconstruction. In addition to the use of titanium plates and screws, clinical applications and attempts using bioabsorbable materials for osteofixation surgery are increasing with demands to avoid secondary surgery for the removal of plates and screws. Synthetic polymeric plates and screws were developed, reaching satisfactory physical properties comparable to those made with titanium. Although these polymeric materials are actively used in clinical practice, there remain some limitations to be improved. Due to questionable physical strength and cumbersome molding procedures, interests in resorbable metal materials for osteofixation emerged. Magnesium (Mg) gained attention again in the last decade as a new metallic alternative, and numerous animal studies to evaluate the possibility of clinical application of Mg-based materials are being conducted. Thanks to these researches and studies, vascular application of Mg-based biomaterials was successful; however, further studies are required for the clinical application of Mg-based biomaterials for osteofixation, especially in the facial skeleton. The review provides an overview of bioabsorbable osteofixation materials in maxillofacial bone surgery from polymer to Mg.

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Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models

Cited by 45 publications

References 44 publications

Microstructure and Corrosion of Cast Magnesium Alloy ZK60 in NaCl Solution

Microstructure and Corrosion of Cast Magnesium Alloy ZK60 in NaCl Solution

Biodegradation of Mg-14Li alloy in simulated body fluid: A proof-of-concept study

Bioabsorbable Osteofixation Materials for Maxillofacial Bone Surgery: A Review on Polymers and Magnesium-Based Materials

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